A5067697875- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Advanced Sensor and Energy Harvesting Materials
- Dielectric materials and actuators
- Molecular Junctions and Nanostructures
- Silicone and Siloxane Chemistry
- Machine Learning in Materials Science
- Lung Cancer Treatments and Mutations
- Thermodynamic properties of mixtures
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Occupational exposure and asthma
- Polymer crystallization and properties
- Advanced Physical and Chemical Molecular Interactions
- Occupational and environmental lung diseases
- Conducting polymers and applications
University of Strathclyde
2016-2022
Fibrogenic processes instigate fatal chronic diseases leading to organ failure and death. Underlying biological involve induced massive deposition of extracellular matrix (ECM) by aberrant fibroblasts. We subjected diseased primary human lung fibroblasts an advanced three-dimensional phenotypic high-content assay screened a repurposing drug library small molecules for inhibiting ECM deposition. Fibrotic Pattern Detection Artificial Intelligence identified tranilast as effective inhibitor....
Idiopathic pulmonary fibrosis (IPF) represents a progressive interstitial lung disease with mean survival time of 3-5 years. Approved pharmacological therapies may slow down, but not stop progression. IPF pathogenesis is characterized by the deposition excessive amounts fibrotic extracellular matrix activated myofibroblasts resulting in loss function. We developed phenotypic drug discovery assay measuring ECM primary human fibroblasts (pHLFs) derived from patients treated transforming growth...