A5101683129- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Metabolomics and Mass Spectrometry Studies
- Cell Image Analysis Techniques
- Analytical Chemistry and Chromatography
- Urological Disorders and Treatments
- Molecular Sensors and Ion Detection
- Sexual Differentiation and Disorders
- Spectroscopy and Laser Applications
- AI in cancer detection
- Financial Literacy, Pension, Retirement Analysis
- Thermography and Photoacoustic Techniques
- Advanced X-ray and CT Imaging
- Connexins and lens biology
- Diabetic Foot Ulcer Assessment and Management
- Conducting polymers and applications
- Optical Imaging and Spectroscopy Techniques
- Intestinal and Peritoneal Adhesions
- Housing, Finance, and Neoliberalism
- Hernia repair and management
- Intraperitoneal and Appendiceal Malignancies
- Protein Structure and Dynamics
- Total Knee Arthroplasty Outcomes
- Graphene research and applications
- Infections and bacterial resistance
University of Pennsylvania
2022
University of Bath
2022
University of Strathclyde
2016-2020
AID Atlanta
2020
Tripler Army Medical Center
2017-2020
Glasgow Life
2016-2019
University of Rhode Island
2017
University of Tennessee System
2015
Birkbeck, University of London
2004
Non-specific symptoms, as well the lack of a cost-effective test to triage patients in primary care, has resulted increased time-to-diagnosis and poor prognosis for brain cancer patients. A rapid, cost-effective, could significantly improve this patient pathway. blood using attenuated total reflection (ATR)-Fourier transform infrared (FTIR) spectroscopy detection cancer, alongside machine learning technology, is advancing towards clinical translation. However, whilst methodology simple does...
Fourier transform infrared (FTIR) spectroscopy has long been established as an analytical technique for the measurement of vibrational modes molecular systems.
Pre-processing is an essential step in the analysis of spectral data. Mid-IR spectroscopy biological samples often subject to instrumental and sample specific variances which may conceal valuable information. Whilst pre-processing can effectively reduce this unwanted variance, plethora possible processing steps has resulted a lack consensus field, meaning that outputs are not comparable. As under investigation, here we present systematic approach for defining optimum protocol biofluid...
There are currently no methods in place for the early detection of brain cancer. A reliable serum triage test could avoid need surgery, and speed up time to definitive treatment. Could high-throughput infrared spectroscopy fill void?
Background: To support the early detection and diagnosis of brain tumours we have developed a rapid, cost-effective easy to use spectroscopic liquid biopsy based on absorbance infrared radiation. We previously reported highly sensitive results our approach which can discriminate patients with recent tumour asymptomatic controls. Other approaches (e.g., genetic material) report lower classification accuracy for early-stage tumours. In this manuscript present an investigation into link between...
Early diagnosis of brain tumours is challenging and a major unmet need. Patients with most often present non-specific symptoms more commonly associated less serious diagnoses, making it difficult to determine which patients prioritize for imaging. Delays in affect timely access treatment, potential impacts on quality life survival. A test help identify are likely have tumour at an earlier stage would dramatically impact by prioritizing demand diagnostic imaging facilities. This clinical...
Abstract Background Diagnostic delays impact the quality of life and survival patients with brain tumors. Earlier expeditious diagnoses in these are crucial to reduce morbidities mortalities associated A simple, rapid blood test that can be administered easily a primary care setting efficiently identify symptomatic who most likely have tumor would enable quicker referral imaging for those need it most. Methods Blood serum samples from 603 were prospectively collected analyzed. Patients...
In recent years, the diagnosis of brain tumors has been investigated with attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy on dried human serum samples to eliminate spectral interferences water component, promising results. This research evaluates ATR-FTIR both liquid and air-dried investigate "digital drying" as an alternative approach for analysis spectra obtained from samples. Digital drying approaches, consisting subtraction least-squares method, have...
Abstract This article provides a comprehensive history of default risk for newly originated home mortgages in the USA over past quarter century. The loan-level source data include entire guarantee book Fannie Mae and Freddie Mac. We track many loan characteristics produce summary measure risk. Among our results, we show that mortgage had already risen 1990s, planting seeds financial crisis well before actual event. Our results also cast doubt on explanations focus borrowers with low credit...
Improved selectivity and sensitivity using covalent fluorophore–cyclodextrin analogues resulted in 100% successful classification for five classes of analytes.
Attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) spectroscopy alongside machine learning (ML) techniques is an emerging approach for the early detection of brain cancer in clinical practice. A crucial step acquisition IR spectrum transformation time domain signal from biological sample to a frequency via discrete Fourier transform. Further pre-processing typically applied reduce non-biological variance, and thus improve subsequent analysis. However, often assumed be...
A simple first-principles approach is used to estimate the core level shifts observed in X-ray photoelectron spectroscopy for 4f electrons of Hf, Ta, W, and Re; these elements were selected because their levels are relatively close Fermi energy. The first tested by modeling surface low-index surfaces four elemental metals, followed its application well-studied material TaSe2 commensurate charge density wave (CDW) phase, where agreement with experimental data found be good, showing that this...
Abstract The development of a robust multi-cancer early detection (MCED) test would be transformational within the cancer diagnostics field, as earlier is vital to inhibit disease progression, improve patient prognosis and reduce mortality rates. In this large-scale spectroscopic study, we present Dxcover® Cancer Liquid Biopsy, world’s first infrared spectroscopy-based blood for multiple cancers. full cohort (n=2094) was comprised patients with confirmed diagnosis (n=1543), symptomatic...
Abstract Background: Early detection of cancer is vital to improve patient survival, since earlier diagnosis and treatment maximizes the opportunity combat or control disease progression. Specifically for colorectal (CRC), average 5-survival rate after decreases from 91% in early-stage CRC, as low 15% stage IV CRC. Furthermore, rapid subsequent removal pre-cancerous adenomas - e.g., advanced (AA) can survival rates affected patients. Current stool-based tests, such FIT FIT-DNA, have poor AA...
In Brief Mycobacterium haemophilum is likely an underrecognized cause of infection among patients with deficits in their cell-mediated immunity. Despite its name, which translates to “blood loving,” it remains unclear whether hyperferritinemic are also at higher risk this infection. We present a 24-year-old woman disseminated M. who has hyperferritinemia and T-cell acute lymphoblastic leukemia remission was initially misdiagnosed as having erythema nodosum avascular necrosis. This report...
Disorders of sexual development are rare and carry high potential for medical psychosocial co-morbidities. A 4 year old female presented with non-reducible bilateral inguinal masses. Physical exam was consistent a healthy child normal external genitourinary exam, maturity rating 1. Elective general surgical repair scheduled. Pre-surgical ultrasound imaging revealed isolated loops bowel in each canal, no other masses, visualized cervix, non-visualized uterus. Further work up initiated upon...