A5103144749- Sepsis Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Lymphoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Retinal Diseases and Treatments
- Inflammation biomarkers and pathways
- Glaucoma and retinal disorders
- S100 Proteins and Annexins
- Retinal and Optic Conditions
- Meat and Animal Product Quality
- Corneal Surgery and Treatments
- Pediatric Urology and Nephrology Studies
- Electrospun Nanofibers in Biomedical Applications
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Optical Coherence Tomography Applications
- Kidney Stones and Urolithiasis Treatments
- Ovarian cancer diagnosis and treatment
- Ocular Surface and Contact Lens
- Immunotherapy and Immune Responses
- Gout, Hyperuricemia, Uric Acid
- Advanced Mathematical Theories and Applications
- Mechanics and Biomechanics Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Eosinophilic Esophagitis
Peking Union Medical College Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2024
Guangxi Medical University
2020-2024
Guangdong Academy of Agricultural Sciences
2022-2023
First Hospital of Jilin University
2017-2023
Jilin University
2017-2023
Tianjin University of Traditional Chinese Medicine
2021
The First Affiliated Hospital, Sun Yat-sen University
2013-2020
Sun Yat-sen University
2011-2020
Beijing Hospital
2020
The drug efflux transporter ABCB5 identifies cancer stem-like cells (CSC) in diverse human malignancies, where its expression is associated with clinical disease progression and tumor recurrence. confers therapeutic resistance, but other functions tumorigenesis independent of have not been described that might help explain why it so broadly overexpressed cancer. Here we show melanoma-initiating cells, controls IL1β secretion, which serves to maintain slow cycling, chemoresistant through an...
Abstract Introduction Many studies have shown that monocyte human leukocyte antigen-DR (mHLA-DR) expression may be a good predictor for mortality in severe septic patients. On the contrary, other found mHLA-DR was not useful prognostic marker sepsis. Few taken changes of during treatment into consideration. The objective this study to estimate value predict Methods In prospective observational study, measured by flow cytometry peripheral blood from 79 adult patients with levels were...
Rheumatoid arthritis (RA), an autoimmune disease, is characterized by inflammatory cell infiltration that damages cartilage, disrupts bone, and impairs joint function. The therapeutic efficacy of RA treatments with the severely affected side remains unsatisfactory despite current treatment methods primarily focus on anti-inflammatory activity, largely because complicatedly pathological mechanisms. A recently identified mechanism for development involves interaction autoantibodies various...
Flk-1+CD31–CD34– mesenchymal stem cells (MSCs) are multipotent with extensive proliferation ability and immunomodulatory function. On the basis of our previous work showing their potential application in tissue engineering immune diseases, we designed a preclinical Phase I trial to evaluate feasibility safety intravenous infusion these after ex vivo expansion. Rhesus monkey human MSCs were isolated from bone marrow passaged maximum six passages. Karyotype analysis showed remained normally...
Milk fat globule factor-E8 (MFG-E8) has been regarded as a key factor involved in the phagocytosis of apoptotic cells. We induced lentivirus into microglial cells for augmentation or abrogation MFG-E8 expression mouse cells, and investigated phosphatidylserine tagged human red blood (hRBCs) co-cultures. Increased levels were associated with significant increase phagocytic activity compared to controls. Conversely, dramitically decreased due MFG-E8. In addition, inflammatory cytokines, TNF-α...
The aim of this study was to evaluate the angiogenic capacity and proteolytic mechanism coculture using human amniotic mesenchymal stem cells (hAMSCs) with umbilical vein endothelial (HUVECs) in vivo vitro by comparing those bone marrow HUVEC. For experiment, (HUVEC-monoculture, HUVEC-hAMSC coculture, HUVEC-BMMSC coculture) were seeded fibrin gels injected subcutaneously nude mice. samples collected on days 7 14 histologically analyzed H&E CD31 staining. CD31-positive staining percentage...
Background The burden of metabolic syndrome (MetS) continues to rise globally and is associated with complications multiple organ systems. We aimed identify the association between changes in MetS status accelerated renal function progression through a regional epidemiological survey China, thus discovering influence factors treatable potential. Methods This study was population-based conducted 2008 2014, assessing representative sample 5,225 individuals from rural areas China. They were...
To evaluate the values of 4 tumor markers in serum and ascites their ascites/serum ratios identification diagnosis benign malignant ascites.A total 76 patients were selected as subjects divided into group (45 cases) (31 cases). Samples all hospitalized collected before treatment. The levels carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), cancer 125 (CA125) carbohydrate 19-9 (CA19-9) detected by chemiluminescence (CLIA) .CEA, AFP CA19-9 both well CA125 evidently higher than (P<0.01)....
Purpose.: The rhodopsin−/− C57Bl/6 (rho−/−) mouse is a very important model for understanding retinal degenerative diseases. In this study, spectral domain optical coherence tomography (SD-OCT) was used to monitor the dynamic morphological changes in retina of rho−/− mice. Methods.: Rho−/− mice and wild type (B6) at age 3, 6, 9, 12 weeks were investigated using SD-OCT obtain cross-sectional images retina. outer nuclear layer (ONL) thickness measured. Histological sections compare OCT data....
Choroidal neovascularization (CNV) is a major cause of visual loss with age-related macular degeneration (AMD). We evaluated whether blockade phosphatidyl-inositol-3-kinase (PI3K) and the mammalian target rapamycin (mTOR), by impairing VEGF-A other growth factor receptors like platelet-derived (PDGF), would reduce laser-induced CNV in mice.Choroidal lesions were induced C57BL/6 mice. Two groups mice received oral GSK2126458 (3 mg/kg) or vehicle for 14 days following laser, whereas three...
Mesenchymal stem cells (MSCs) have been extensively investigated in the field of regenerative medicine. Human bone MSCs (BMSCs) become a common type seed cell for tissue engineering. However, viability and number BMSCs are negatively correlated with donor age, as extraction process is painful, this method has not widely used. As human umbilical cord (UCMSCs) may be harvested inexpensively inexhaustibly, present study evaluated compared potential UCMSCs to determine whether used novel...
Acute myocardial infarction (AMI) is a serious threat to human health. Stem cells can serve as ideal seed for repair and regeneration; however, insufficient homing the infarcted areas poor differentiation limit their further clinical application. Chemokine (C-X-C motif) ligand 12 (CXCL12) an important stem cell factor, Bone morphogenetic protein-2 (BMP2) differentiation-promoting factor. In this study, we designed microbubbleadenovirus complexes investigated functional benefit of co-delivery...
Conventional classifications of gastroenteropancreatic neuroendocrine tumours (GEP- NETs) are rather unsatisfactory because the variation in survival within each subgroup. Molecular markers being found able to predict patient outcome more and tumours. The aim this study was characterize expression proteins cyclin D1, E P53 GEP- NETs assess any prognostic impact. Tumor specimens from 68 patients with a complete follow-up were studied immunohistochemically for expression. High D1...
Urinary stone disease (USD) has been associated with an increased risk of chronic kidney (CKD) and end-stage renal in Western populations. However, the metabolic disorders unilateral bilateral stones association these types CKD tubular injury markers, such as urine N-acetyl-ß-D-glucosaminidase (NAG) alpha-1-microglobulin (α1-MG), have not fully examined.We performed a cross-sectional study 10,281 participants rural China 2014. All subjects underwent ultrasound to detect USD; formers were...
Carotenoid consumption decreases the risk of cancer, osteoporosis, or neurodegenerative diseases through interrupting formation free radicals. The deposition carotenoids in chicken skin makes color turn from white into yellow. enzyme β-carotene oxygenase 2 (BCO2) plays a key role during degradation process skin. How BCO2 affects and whether it is factor that results phenotypic difference between yellow- white-skin chickens are still unclear. In this research, measurement concentration by...
Aim . The purpose of this study was to investigate the relationship between upper limbs’ three functional partitions and golden curve. Materials Methods We measured 30 subjects’ right or left limb data them curve by use SPSS version 20.0 statistical software (SPSS, Inc., Chicago, Illinois), one-sample <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>t</mml:mi></mml:mrow></mml:math>-test. Results There are four points on human’s limbs which have no difference...
Background Many studies have shown that continuous renal replacement therapy (CRRT) could clean lactate and treat the hyper-lactatemia. On contrary, some other found filter clearance only accounted for a very small part of total hemofilter's contribution to overall was negligible. The objective this study evaluate effects various doses veno-venous hemofiltration (CVVH) on plasma elimination in critically ill patients. Methods Patients were divided into three groups according their incipient...