A5030693537- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Ultrasound in Clinical Applications
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Fibrosis and Remodeling
- Cardiac Arrest and Resuscitation
- Cardiovascular and Diving-Related Complications
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac electrophysiology and arrhythmias
- Sexual function and dysfunction studies
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Circular RNAs in diseases
- ECG Monitoring and Analysis
- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Phonocardiography and Auscultation Techniques
- Cardiac Health and Mental Health
- Signaling Pathways in Disease
Ipswich Hospital
2015-2024
East Suffolk and North Essex NHS Foundation Trust
2021-2024
Glenfield Hospital
2013-2017
University of Leicester
2011-2017
NIHR Leicester Cardiovascular Biomedical Research Unit
2013-2014
Centre Hospitalier de Luxembourg
2013
National Institute for Health Research
2013
University Hospital of Wales
2005-2013
Cardiff University
2005
Background— Left ventricular (LV) remodeling after acute myocardial infarction is associated with adverse prognosis. MicroRNAs (miRNAs) regulate the expression of several genes involved in LV remodeling. Our aim was to identify miRNAs infarction. Methods and Results— We studied 90 patients first ST-segment–elevation A derivation cohort consisted 60 characterized by echocardiography predischarge at 6-month follow-up. Thirty magnetic resonance imaging 4-month follow-up were validation cohort....
We prospectively assessed the implementation of venous thromboembolism (VTE) prophylaxis guidelines and impact grand round presentation data in changing clinical practice. Two NHS teaching hospitals were studied for 24 months from January 2003. Patients risk stratified according to THRIFT (thromboembolic factor) consensus group compared with recommendations ACCP (American College Chest Physicians) groups. Six following initial results, a further analysis was made assess changes 1128 patients...
Abstract Aims To assess the real world impact of updated clinical guidelines and literature on management patients undergoing stress echocardiography for assessment inducible ischaemia across a national health service. Methods Results A total 13,819 from 32 UK hospitals, referred between 2015-2023, were analysed two phases: phase 1 (2015-2020) 2 (2020-2023). Follow-up data one year was available 4,920 participants through NHS Digital. Patients in younger, presented with higher cardiovascular...
Abstract Aims Stress echocardiography is widely used to identify obstructive coronary artery disease (CAD). High accuracy reported in expert hands but dependent on operator training and image quality. The EVAREST study provides UK-wide data evaluate real-world performance of stress echocardiography. Methods results Participants undergoing for CAD were recruited from 31 hospitals. followed up through health records which underwent adjudication. Cardiac outcome was defined as anatomically or...
Microvascular obstruction (MVO) describes suboptimal tissue perfusion despite restoration of infarct-related artery flow. There are scarce data on Infarct Size (IS) and MVO in relation to the mode timing reperfusion. We sought characterise prevalence extent microvascular injury IS using Cardiovascular magnetic resonance (CMR), reperfusion following acute ST-Elevation Myocardial Infarction (STEMI).
We prospectively assessed the implementation of venous thromboembolism (VTE) prophylaxis guidelines and impact grand round presentation data in changing clinical practice. Two NHS teaching hospitals were studied for 24 months from January 2003. Patients risk stratified according to THRIFT (thromboembolic factor) consensus group compared with recommendations ACCP (American College Chest Physicians) groups. Six following initial results, a further analysis was made assess changes 1128 patients...
To determine if global strain parameters measured by cardiovascular magnetic resonance (CMR) acutely following ST-segment Elevation Myocardial Infarction (STEMI) predict adverse left ventricular (LV) remodelling independent of infarct size (IS). Sixty-five patients with acute STEMI (mean age 60 ± 11 years) underwent CMR at 1–3 days post-reperfusion (baseline) and 4 months. Global peak systolic circumferential (GCS), tagging Feature Tracking (FT), longitudinal (GLS), FT, were calculated...
Abstract Aims Stress echocardiography is widely used to assess patients with chest pain. The clinical value of a positive or negative test result inform on likely longer-term outcomes when applied in real-world practice across healthcare system has not been previously reported. Methods and results Five thousand five hundred three recruited 32 UK NHS hospitals between 2018 2022, participating the EVAREST/BSE-NSTEP prospective cohort study, data medical up 2023 available from England were...
Abnormal prolongation or shortening of the QT interval is associated with increased risk for ventricular arrhythmias and sudden cardiac death. For continuous monitoring, widespread use, prevention events, advanced wearable technologies are emerging as promising surrogates conventional 12‑lead electrocardiogram (ECG) assessment. Previous studies have shown a good agreement between corrected (QTc) intervals measured on smartwatch ECG 12-lead ECG, but clinical accuracy computerized algorithms...
<h3>Objectives</h3> For clinicians to be aware of different types atrial septal defect and the rare manifestations sinus venosus (SV-ASD). To understand effectiveness diagnostic modalities reach diagnosis. familiarize with possibility inadvertent right ventricular lead placement in left ventricle patients who requires a permanent pacemaker. <h3>Introduction</h3> Atrial Septal Defect (ASD) is one commonest congenital heart defects. Among its five subtypes which include patent foramen ovale,...
Abstract Background Stress echocardiography is widely used to detect coronary artery disease, but little evidence on downstream hospital costs in real-world practice available. We examined how stress accuracy and vary across NHS hospitals identified key factors that affect help inform future clinical planning guidelines. Methods Data 7636 patients recruited from 31 within the UK between 2014 2020 as part of EVAREST/BSE-NSTEP study, were used. included all diagnostic tests, procedures,...
Background Patients with dysglycemia at the time of ST-elevation myocardial infarction (STEMI) have a worse prognosis. The reasons for this are not entirely clear. Admission hyperglycemia has been associated larger infarct size. aims study were to examine relation acute and chronic glycemic state scar salvage characteristics in patients reperfused STelevation infarction.
<h3>Introduction</h3> Patients with dysglycaemia at the time of ST-elevation myocardial infarction (STEMI) have a worse prognosis. The reasons for this are not entirely clear. Admission hyperglycaemia has been associated larger infarct size. aims study were to examine relation acute and chronic glycaemic state scar salvage characteristics in patients reperfused infarction. <h3>Methods</h3> Fifty-six treated first without pre-existing diagnosis Diabetes mellitus prospectively enrolled between...
<h3>Introduction</h3> Erectile dysfunction (ED) is the persistent inability to attain or maintain an erection and affects up 52% of men between ages 40 70. ED independent predictor clinically overt cardiovascular (CV) events, coronary artery disease (CAD), stroke all-cause mortality, preceding these by 2–5 years. has not been evaluated in patients referred a rapid access chest pain clinic (RACPC) for suspected CAD. <h3>Purpose</h3> To prospectively investigate RACPC assess as CAD patients....
Background Cardiac MRI (CMR) provides unique characterization of myocardial injury post acute ST-Elevation Myocardial Infarction (STEMI). It is the gold standard for non-invasive measurement Infarct Size (IS) and tissue perfusion during STEMI. Microvascular obstruction describes suboptimal despite restoration flow in infarct-related artery (IRA). IS MVO are independent predictors o fa dverse remodelling prognosis generally assumed to be related primarily reperfusion. There a paucity data on...
ObjectivesThe aim of this study was to compare and assess the reproducibility left ventricular (LV) circumferential peak systolic strain (PeakE cc ) rate (SR) measurements using standard high temporal resolution myocardial tissue tagging in patients with severe aortic stenosis (AS).
<h3>Introduction</h3> Adverse Left ventricular (LV) remodelling with increase in LV volumes and reduction ejection fraction (EF) can occur following ST-elevation myocardial infarction (STEMI) confers worse prognosis. is mediated part by degradation of the extra-cellular matrix, through activity Matrix Metalloproteinase (MMP) enzymes their intrinsic inhibitors, tissue inhibitors matrix metalloproteinases (TIMPs). We examined relationships NTproBNP, MMP TIMP biomarkers measured at index...
Purpose: Left ventricular remodelling following ST-elevation myocardial infarction (STEMI) is associated with worse outcomes. NTproBNP a predictor of LV systolic impairment and adverse We assessed the relationship infarct characteristics by cardiac magnetic resonance (CMR) in patients presenting first STEMI treated primary percutaneous coronary intervention (PPCI). Methods: Forty-seven consecutive (mean age 60.5±12.3 years, 42 male) PPCI (median time to reperfusion 150 minutes, IQR 120...
<h3>Introduction</h3> Cardiac MRI (CMR) provides unique characterisation of myocardial injury post acute STEMI. It is the gold standard for non-invasive measurement Infarct Size (IS) and tissue perfusion during Microvascular obstruction (MVO) describes suboptimal despite restoration flow in infarct-related artery (IRA). IS MVO are independent predictors adverse remodelling prognosis generally assumed to be related primarily reperfusion. CMR extent decreases after 48 h There a dearth data on...