A5040916308- Migraine and Headache Studies
- Vestibular and auditory disorders
- Diet and metabolism studies
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Biochemical effects in animals
- Photoreceptor and optogenetics research
- Trigeminal Neuralgia and Treatments
- Ocular and Laser Science Research
- EEG and Brain-Computer Interfaces
- Glaucoma and retinal disorders
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Metabolism and Genetic Disorders
- Hemispheric Asymmetry in Neuroscience
- Mitochondrial Function and Pathology
- Long-Term Effects of COVID-19
- Alcoholism and Thiamine Deficiency
- Lipoproteins and Cardiovascular Health
- Amyotrophic Lateral Sclerosis Research
- Peripheral Neuropathies and Disorders
- Nutritional Studies and Diet
- Pain Mechanisms and Treatments
- Psychedelics and Drug Studies
- Adipose Tissue and Metabolism
- Complementary and Alternative Medicine Studies
Sapienza University of Rome
2011-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2016-2017
Universidad Latina
2013-2014
University of Rome Tor Vergata
1995-2002
Background and purpose Ketogenesis is a physiological phenomenon due to starvation or ketogenic diet ( KD ), drastic restricted carbohydrate dietary regimen that induces lipid metabolism ketone body synthesis. Two patients whose migraines disappeared only during, not outside, cycles of very‐low‐calorie performed reduce their weight were recently observed. To confirm our observation, in dietitian clinical setting two parallel groups migraineurs, one receiving 1‐month prescription followed by...
Episodic migraine is characterized by decreased high-frequency somatosensory oscillations (HFOs), reflecting thalamo-cortical activity, and deficient habituation of low-frequency (LF-) evoked potentials (SSEPs) to repetitive sensory stimulation between attacks. Here, we study conventional LF-SSEPs HFOs in episodic migraineurs who developed chronic (CM).Thirty-four (15 interictally [MOii], 19 ictally [MOi]) CM patients underwent right median nerve SSEPs. The patient groups were compared a...
Here, we aim to identify cortical electrofunctional correlates of responsiveness short-lasting preventiveintervention with ketogenic diet (KD) in migraine. Eighteen interictal migraineurs underwent visual (VEPs) and median nerve somatosensory (SSEPs) evokedpotentials before after 1 month KD during ketogenesis. We measured VEPs N1-P1 SSEPs N20-P25 amplitudes respectively six two sequential blocks 100 sweeps as well habituation theslope the linear regression between block 6 for or 2 SSEPs....
Patients suffering from migraine with aura can have either pure visual auras or complex sensory disturbances and dysphasia, both. Few studies searched for possible pathophysiological differences between these two subgroups of patients.Methods - Forty-seven patients were subdivided in a subgroup exclusively (MA, N = 27) another neurological (MA+, 20). We recorded pattern-reversal evoked potentials (VEP: 15 min arc cheques, 3.1 reversal per second, 600 sweeps) measured amplitude habituation...
Background We studied lateral inhibition in the somatosensory cortex of migraineurs during and between attacks, searched for correlations with thalamocortical activity clinical features. Participants methods Somatosensory evoked potentials (SSEP) were obtained by electrical stimulation right median (M) or ulnar (U) nerves at wrist simultaneous both (MU) 41 migraine without aura patients, 24 (MO), 17 healthy volunteers (HVs). determined percentage N20–P25 component using formula [(100)–MU/(M...
Summary Impaired paired associative stimulation (PAS)-induced long-term synaptic plasticity characterizes migraine without aura patients between attacks. We suggest that the malfunctioning in PAS-induced effects reflects low cortical preactivation, which prevents short-term and longer-term changes effectiveness. The period attacks is characterized by paradoxical responses to repetitive sensory transcranial magnetic (TMS). Abnormal functional may play a role can be assessed experimentally...
A short ketogenic diet (KD) treatment can prevent migraine attacks and correct excessive cortical response. Here, we aim to prove if the KD-related changes of excitability are primarily due cerebral cortex activity or modulated by brainstem.Through stimulation right supraorbital division trigeminal nerve, concurrently interictally recorded nociceptive blink reflex (nBR) pain-related evoked potentials (PREP) in 18 migraineurs patients without aura before after 1-month on KD, while metabolic...
Cluster headache (CH) patients often receive unsatisfactory treatment and may explore illicit substances as alternatives. We aimed to this use of drugs for CH treatment.We invited from an Internet-based self-help group complete a questionnaire regarding their therapeutic substances.Of the 54 respondents, 29 were classified chronic 39 drug-resistant cases. Fifty had previously tried subcutaneous sumatriptan, 40 O2, 48 at least one prophylactic treatment. All specified that they dissatisfied...
Background: We investigated whether chronic headache related to medication overuse (MOH) is associated with changes in brain mechanisms regulating inhibitory cortical responses compared healthy volunteers and episodic migraineurs recorded between attacks, these differ according the drug overused. Subjects Methods: studied 40 MOH patients whose symptoms were triptans alone, non-steroidal anti-inflammatory drugs (NSAIDs) or both medications combined, 12 13 volunteers. used high-intensity...
Background We previously observed impaired habituation mechanisms of the conventional blink reflex (BR) in patients with episodic cluster headache (ECH) during bout, studying only affected side. Here, we have studied nociceptive-specific BR (nBR) both on and non-affected sides, relation to clinical features. Participants methods recorded nBR 18 ECH healthy volunteers (HVs). compared pain threshold, area, nBR, for sides. Results In patients, threshold side was lower than that ( p = 0.009),...
Sporadic Creutzfeldt-Jakob disease is characterized by rapid cognitive and neuropsychiatric impairment. The Heidenhain variant of known for isolated visual disturbance that precedes other features. Periodic sharp wave complexes on EEG are typical sporadic disease, but at the onset, electroclinical pattern may be unclear suggest hypothesis a non-convulsive status epilepticus. Furthermore, epilepticus could coexist simultaneously. We report case patient admitted to our hospital progressive...
A discrete model has been developed at Tor Vergata University, which describes vegetation as an ensemble of discs and cylinders overlying a homogeneous half-space with rough interface. The predicts the backscatter coefficient including multiple scattering effects. first version, was based on scalar approach (2 Stokes components) now improved in order to get fully polarimetric (4 components). Soil is represented, for each pair incidence directions, by 4/spl times/4 scatter matrix, computed...
Background Single-pulse transcranial magnetic stimulation studies of motor cortex have the advantage relying on an objective measure, evoked potential (MEP) recorded in peripheral muscles, to non-invasively explore cortical excitability. Previously, thresholds for MEP were found be normal, increased or even reduced migraine. In present study, we investigated whether level excitability changes with distance from last migraine attack could explain these inconsistent results.
Ketogenic diet (KD) is a dietetic regimen that mimics fasting in producing ketone bodies, which seems to have potential role treating migraine. From animal and human models emerges KD might affects CNS at multiple levels: it able normalize cortical dysexcitability reduce spreading depression velocity of propagation, mechanisms are potentially interest migraine pathophysiology.