A5084021648- Immune Cell Function and Interaction
- Phytochemicals and Antioxidant Activities
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Macrophage Migration Inhibitory Factor
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Folate and B Vitamins Research
- Cancer Mechanisms and Therapy
- Fungal Biology and Applications
- Nuclear Receptors and Signaling
- Estrogen and related hormone effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hops Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Neurological Complications and Syndromes
- Migraine and Headache Studies
- Tuberculosis Research and Epidemiology
- interferon and immune responses
- Dermatology and Skin Diseases
- Hormonal Regulation and Hypertension
- T-cell and B-cell Immunology
- Research on Leishmaniasis Studies
- Garlic and Onion Studies
- Immune cells in cancer
The Ohio State University Wexner Medical Center
2021-2025
The Ohio State University
2021-2024
Vita-Salute San Raffaele University
1996
Head and neck squamous cell carcinoma (HNSCC) continues to be among the most common malignancies worldwide with limited treatment options for patients. Targeting PD-1/PDL-1 axis is currently only FDA approved immune checkpoint inhibitor HNSCC. Novel therapies targeting other pathways are needed along testing a combinational approach find new more efficient ways treat this disease. We utilized tamoxifen inducible TgfβR1/Pten deletion mouse model explore efficacy of combined anti-LAG-3...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a significant problem frequently resistant to current treatments. STAT1 important in anti-tumour immune responses against HNSCC. However, the role of expression by tumour cells its regulation during HNSCC unclear. Methods We determined effects inhibition on development immunity CAL27 UMSCC22A lines vitro carcinogen-induced model vivo. Results siRNA knockdown human impaired their proliferation immunosuppressive marker PD-L1....
Abstract MicroRNA-21 (miR-21) inhibits IL-12 expression and impairs the Th1 response necessary for control of Leishmania infection. Recent studies have shown that infection induces miR-21 in dendritic cells macrophages, inhibition restores expression. Because is known to be expressed due inflammatory stimuli a wide range hematopoietic cells, we investigated role regulating immune responses during visceral leishmaniasis (VL) caused by donovani We found was significantly elevated monocytes,...
Berries have gained widespread recognition for their abundant natural antioxidant, anti-inflammatory, and immunomodulatory properties. However, there has been limited research conducted thus far to investigate the role of active constituents berries in alleviating contact hypersensitivity (CHS), most prevalent occupational dermatological disease. Our study involved an ex vivo investigation aimed at evaluating impact black raspberry extract (BRB-E) various compounds found berries, such as...
Head and neck squamous cell carcinomas (HNSCC) are one of the most diagnosed malignancies globally, with a 5-year survival rate approximately 40% to 50%. Current therapies limited highly invasive surgery, aggressive radiation, chemotherapies. Recent reports have demonstrated potential phytochemical properties black raspberries in inhibiting progression various cancers including HNSCCs. However, effects raspberry extracts on immune cells tumor microenvironment, specifically regulatory T...
Recent reports suggest that glucocorticoids (GCs), which can be synthesized in the oral mucosa, play an important role cancer development. Therefore, objectives of this study were to characterize GC system cancer, and determine effect black raspberry (BRB) administration on modulation during chemoprevention. We determined expression enzymes various cell lines, investigated inactivating enzyme HSD11B2 CAL27 cells using siRNA mediated knockdown approaches. Using two vivo models carcinogenesis...
Head and neck squamous cell carcinoma (HNSCC) is a significant public health concern worldwide. Immunomodulatory targets in the HNSCC tumor microenvironment are crucial to enhance efficacy of immunotherapy. Macrophage migration inhibitory factor (MIF) pro-inflammatory cytokine that has been linked poor prognosis many cancers, but mechanistic role MIF remains unclear. Using murine orthotopic oral cancer model Mif
Head and neck squamous cell carcinoma (HNSCC) is common deadly, there a need for improved strategies to predict treatment responses. Ionizing radiation (IR) has been demonstrated improve HNSCC outcomes, but its effects on immune responses are not well characterized. We determined the impact of IR T ex vivo. Human mouse cells were exposed ranging from 20 200 Gy determine viability ability stimulate T-cell-specific Lymph node LY2 MOC2 tumor-bearing or non-tumor-bearing mice re-stimulated with...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a significant public health problem, with need for novel approaches to chemoprevention treatment. Preclinical models that recapitulate molecular alterations occur in clinical HNSCC patients are needed better understand immune mechanisms of carcinogenesis, efficacy We optimized mouse model tongue carcinogenesis discrete quantifiable tumors via conditional deletion Tgfβr1 Pten by intralingual injection tamoxifen. characterized the...