A5063586287- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Connective tissue disorders research
- Protease and Inhibitor Mechanisms
- Bone and Dental Protein Studies
- Peptidase Inhibition and Analysis
- Hepatitis C virus research
- Heat shock proteins research
- Cardiomyopathy and Myosin Studies
- Collagen: Extraction and Characterization
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Artificial Intelligence in Healthcare
- Cardiovascular Effects of Exercise
- Machine Learning in Healthcare
- Sphingolipid Metabolism and Signaling
- Periodontal Regeneration and Treatments
- Probiotics and Fermented Foods
- Cell Adhesion Molecules Research
- Tissue Engineering and Regenerative Medicine
- Bee Products Chemical Analysis
- Ion Transport and Channel Regulation
- Galectins and Cancer Biology
- Antifungal resistance and susceptibility
- Viral Infections and Immunology Research
Indian Institute of Technology Mandi
2022-2025
Institute of Bioinformatics and Applied Biotechnology
2023
Post Graduate Institute of Medical Education and Research
2022
Introduction Collagens, the most abundant proteins in mammals, play pivotal roles maintaining tissue structure, functions, cell-to-cell communication, cellular migration, behavior, and growth. Structures of collagens are highly complex due to presence dynamic post-translational modifications (PTMs), such as hydroxylations (on prolines lysine residues) O-glycosylation hydroxylysines) enzymatically catalyzed during biosynthesis endoplasmic reticulum. Collagen PTMs essential for structural...
Cardiac fibrosis-mediated heart failure (HF) is one of the major forms end-stage cardiovascular diseases (CVDs). fibrosis an adaptive response myocardium upon any insult/injury. Excessive deposition collagen molecules in extracellular matrix (ECM) hallmark fibrosis. This fibrotic initially protects from ventricular rupture. Although mammals this progresses towards scar-tissue formation leading to HF, some fishes and urodeles have mastered art cardiac regeneration following injury-mediated...
Abstract Collagens, the most abundant proteins in mammals, play pivotal roles maintenance of tissue structure, functions, cell-to-cell communication, cellular migration, behavior, and growth. Collagens are highly complex structure due to dynamic post-translational modifications (PTMs) such as hydroxylations (on prolines lysine residues) O-glycosylation hydroxylysines) enzymatically catalyzed during biosynthesis. The prevalent modification fibrillar collagens is prolyl 4-hydroxylation by...
Abstract Huntington's disease (HD) is one of the prominent neurodegenerative diseases, characterized by progressive decline neuronal function, due to accumulation and aggregation misfolded proteins. Pathological progression HD hallmarked aberrant huntingtin protein (HTT) subsequent neurotoxicity. Molecular chaperones (heat shock proteins, HSPs) play a pivotal role in maintaining proteostasis facilitating refolding, degradation, or sequestration limit proteins during However,...