A5101775794- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Liver Disease and Transplantation
- Plant Pathogens and Fungal Diseases
- Antimicrobial Peptides and Activities
- Liver Disease Diagnosis and Treatment
- Nail Diseases and Treatments
- Tuberculosis Research and Epidemiology
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Parasites and Host Interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Biology and Applications
- Hair Growth and Disorders
- Amoebic Infections and Treatments
- Helminth infection and control
- Hepatocellular Carcinoma Treatment and Prognosis
- Antimicrobial Resistance in Staphylococcus
- Reproductive tract infections research
- Respiratory and Cough-Related Research
- Cystic Fibrosis Research Advances
- Antibiotic Resistance in Bacteria
- Biochemical and Structural Characterization
- Antibiotic Use and Resistance
- Bacterial Infections and Vaccines
Post Graduate Institute of Medical Education and Research
2016-2025
National Institute of Pharmaceutical Education and Research
2025
Institute of Medical Sciences
2015-2024
Touro College
2024
University of Wisconsin–Madison
2024
Jawaharlal Nehru Medical College
2024
Liberty University
2024
GD Goenka University
2023
Cooper Hospital
2022-2023
University of Washington
2023
Dermatophytosis due to the Trichophyton mentagrophytes-Trichophyton interdigitale complex is being increasingly reported across India. Reports of therapeutic failure have surfaced recently, but there are no clinical break points (CBP) or epidemiological cutoffs (ECVs) available guide treatment dermatophytosis. In this study, a total 498 isolates T. mentagrophytes -interdigitale were collected from six medical centers over period five years (2014 2018).
Abstract Aims To study the prevalence, risk factors, role of serum biomarkers for diagnosis and impact invasive fungal infections (IFIs) in patients with acute‐on‐chronic liver failure (ACLF). Methods An analysis IFI ACLF (EASL criteria) was conducted retrospectively. The clinically suspected based on EORTC/MSG criteria. demographical, clinical, laboratory details outcomes were analysed. Results Out 264 ACLF, 54 (20.4%) suspicion evaluated diagnosed 39 (14.7%). Invasive candidiasis...
Mucormycosis is an angio-invasive infection, predominantly acquired by inhalation of sporangiospores from the environment. However, burden Mucormycetes in air not well studied. We aimed to estimate spores outdoor and indoor (hospital) environment across different seasons north India. A total 380 samples (n = 180) 200) were included study. Air suctioned using sampler (100 l/min) cultured on Dichloran Rose Bengal Chloramphenicol (DRBC) with benomyl for selective isolation Mucormycetes. The...
This study was designed to understand the molecular mechanisms of azole resistance in Candida tropicalis using genetic and bioinformatics approaches. Thirty-two azole-resistant 10 azole-susceptible (S) clinical isolates C. were subjected mutation analysis target genes including ERG11. Inducible expression 17 other potentially associated with also evaluated. Homology modeling docking performed effect amino acid alterations mediating resistance. Of 32 resistant isolates, 12 (37.5%) showed...
ABSTRACT Apophysomyces elegans was considered a rare but medically important zygomycete. We analyzed the clinical records of eight patients from single center in whom zygomycosis due to A. diagnosed over span 25 months. also attempted DNA-based method for rapid identification fungi and looked interstrain polymorphism using microsattelite primers. Three had cutaneous subcutaneous infections, three isolated renal involvement, one rhino-orbital tissue infection, final patient disseminated...
Echinocandins are frontline antifungal agents in the management of invasive infections due to multidrug resistant Candida auris. The study aimed evaluate echinocandin resistance C. auris isolates multicentric origin, identify mechanism, and analyze pharmacodynamic response caspofungin a neutropenic mouse model infection. A total 199 originating from 30 centers across India were tested for susceptibility echinocandins. Isolates with reduced evaluated
Introduction: Recent years have seen a rise of coagulase-negative staphylococci (CoNS) from common contaminants to agents nosocomial blood stream infections (BSI’s). Molecular typing and establishing correlation with antibiotic resistance is essential particularly in countries like India where genotyping studies for drug-resistant CoNS are sparse. Methods: A prospective study was done over 18 months, wherein 42,693 samples were received, 59 patients BSI due evaluated. The isolates recovered...
Introduction. Histopathological examination (HPE) of tissue helps in the diagnosis invasive fungal infections (IFIs) but cannot identify fungus to genus/species level Gap Statement Available protocols for molecular identification fungi from formalin-fixed and paraffin-embedded (FFPE) tissues have limitations terms extraction target selection, standardisation. Aim. Development sequence-based protocol after DNA tissues. Methodology. A total 63 FFPE histopathology proven IFI cases were used...
Recently, India witnessed an unprecedented surge of coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) cases. In addition to patient management issues, environmental Mucorales contamination possibly contributed the outbreak. A recent study evaluated environment by in hospital setting. However, a considerable number CAM patients were never admitted before development disease. The present study, therefore, planned evaluate patients' residences.The residential 25 with living...
Candida tropicalis arises as one of the predominant non-Candida albicans (NCAC) species causing invasive candidiasis in Asian countries. A rise reports C. with a parallel increase fluconazole resistance has also been observed. The genes and underlying pathways associated azole antifungal is still not properly understood. RT-qPCR most promising approach for expression analysis target to understand mechanisms resistance. reliability reproducibility this technique depend on selection suitable...
Candidaemia is a major cause of morbidity and mortality hospitalised patients, especially in developing countries. This study was conducted to monitor any change species distribution antifungal susceptibility pattern Candida causing candidaemia over the last 20 years.
Identification of Candida auris is challenging and requires molecular or protein profiling-based approaches, availability which limited in many routine diagnostic laboratories, necessitating the development a cost-effective, rapid, reliable method identification. The objective this study was to develop selective medium for C. Eighteen 30 non-C. yeasts were used standardization medium. Sodium chloride (10% 13% concentration) ferrous sulfate (8 mM 15 mM) added yeast extract-peptone-dextrose...