A5100626057- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Hydrogels: synthesis, properties, applications
- Surface Modification and Superhydrophobicity
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 and healthcare impacts
- Cancer, Hypoxia, and Metabolism
- Per- and polyfluoroalkyl substances research
- Surfactants and Colloidal Systems
- Electrostatics and Colloid Interactions
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Polymer Surface Interaction Studies
- Cardiovascular and Diving-Related Complications
Harbin Medical University
2009-2023
Third Affiliated Hospital of Harbin Medical University
2018-2023
Sun Yat-sen University
2022
Sun Yat-sen University Cancer Center
2022
Chinese University of Hong Kong
1998-2000
University of Hong Kong
2000
Shanghai Institute of Organic Chemistry
1998
Fudan University
1998
University of Science and Technology of China
1998
Hypoxia is a common feature of solid tumors and an important contributor to anti-tumor drug resistance. inducible factor-1 (HIF-1) one the key mediators hypoxia signaling pathway, was recently proven be required for sorafenib resistance in hepatocarcinoma (HCC). MicroRNAs have emerged as posttranslational regulators HCC. It reported that miR-338-3p levels are associated with clinical aggressiveness However, roles HCC disease its therapeutic drugs unknown. In this study, we found frequently...
The long non‐coding RNA segment cancer susceptibility candidate 2 (CASC2) has been shown to suppress tumor growth in a variety of cancers, including hepatocellular carcinoma (HCC). However, the mechanism by which CASC2 exerts control over HCC yet be established. In present study, we first demonstrated that is downregulated human tissues and cell lines as compared adjacent non‐tumor (NTTs) liver line, respectively. After finding knockdown significantly promotes cells migration invasion well...
Abstract LncRNA PITPNA-AS1 was a newly identified lncRNA which has never been studied in cancers. Whether participated the development of hepatocellular carcinoma (HCC) is obscure. Given coaction lncRNAs and miRNAs to carcinogenesis, purpose present research inquire how affects HCC progression. Firstly, observed be heightened tissues. Then function assays proved that overexpressing or silencing could manipulate proliferation motility cells. Besides, located cytoplasm. Among candidate...
A combination of laser light scattering (LLS), viscometry, and fluorescence spectroscopy was used to study the association a series fluorocarbon-modified poly(N-isopropylacrylamide) (PNIPAM) copolymers in aqueous solution. The interchain increases as both fluorocarbon content polymer concentration increase, evidenced by changes apparent molar mass, intrinsic viscosity, Huggins constant, excimer-to-monomer intensity ratio. LLS results are well-represented open model. Our also revealed that...
We have previously found that expression of MARVELD1 was remarkably downregulated in multiple tumor tissues, but unclear hepatocellular carcinoma (HCC) and its function has not been explored yet. In the present study, to uncover underlying mechanism pathogenesis development HCC, we investigated pattern effect on proliferation HCC. The results indicated frequent downregulation clinic samples cell lines HCC resulted from promoter methylation, as well genetic deletion. Furthermore, treatment...
Poly(N-isopropylacrylamide) copolymers (PNIPAMs) containing pendent perfluoroalkyl (RF) or dodecyl groups have been synthesized by copolymerization of NIPAM with small amounts RR-acrylates -methacrylates a sulfonamido moiety between the acrylate and RF acrylate. Evidence for strong intermolecular hydrophobic association fluorocarbon is provided large viscosity increases copolymer concentration upon addition NaCl surfactants. These interactions appear to be much stronger than that...
Abstract In this study, we conducted a comprehensive analysis of immune-related and angiogenesis-related genes (IRAR DEGs) in hepatocellular carcinoma (HCC). We utilized data from the TCGA-LIHC project performed expression difference correlation analysis, clinical prognosis enrichment with immune cell infiltration, construction advanced prognostic models, evaluation drug sensitivity. Our findings revealed 18 IRAR DEGs associated both response angiogenesis HCC. identified significant...
Objective To explore the reverse effect of Wt-p53 gene on drug resistance breast cancer cell line MCF-7/A and its possible mechanism.Methods was tranfected into cells through rebuilding adenovirus.The growth curve drawn, cycle distribution apoptosis were checked by FCM.The examined TUNEL.The expression mRNA protein in detected PT-PCR Western blot respec-tively.Results In transfection group cells, there obvious proliferation, p53 24 48 h later.Aneuploid peak before G, stage indicated DNA...
Abstract BACKGROUND: Long non-coding RNAs (lncRNA) have been shown to play important roles in the development and progression of hepatocellular carcinoma (HCC). In this report, we examined role lncRNA LINC00645 HCC. MATERIAL AND METHODS: Based on public databases integrating bioinformatics analyses, over-expression HCC tissues was detected further validated a cohort liver tissues. A series vitro vivo functional experiments were executed investigate carcinogenesis Comprehensive...
Poly(N-isopropylacrylamide) copolymers (PNIPAMs) containing pendent perfluoroalkyl (RF) or dodecyl groups have been synthesized by copolymerization of NIPAM with small amounts RR-acrylates -methacrylates a sulfonamido moiety between the acrylate and RF acrylate. Evidence for strong intermolecular hydrophobic association fluorocarbon is provided large viscosity increases copolymer concentration upon addition NaCl surfactants. These interactions appear to be much stronger than that...