A5052829420- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Hormonal Regulation and Hypertension
- Psychological Treatments and Disorders
- Schizophrenia research and treatment
- Family Caregiving in Mental Illness
- Inflammatory mediators and NSAID effects
- Diabetes and associated disorders
- Ethics and bioethics in healthcare
- Renal and Vascular Pathologies
- Viral gastroenteritis research and epidemiology
- Diabetes Treatment and Management
- vaccines and immunoinformatics approaches
- Eicosanoids and Hypertension Pharmacology
- Economic and Social Issues
- Mental Health Treatment and Access
- Adrenal Hormones and Disorders
- Vitamin D Research Studies
- Diet and metabolism studies
- Philosophical Thought and Analysis
- Psychology Research and Bibliometrics
- Clostridium difficile and Clostridium perfringens research
- Chronic Kidney Disease and Diabetes
Universitat Autònoma de Barcelona
2017-2021
Centre de Recerca en Sanitat Animal
2017-2021
Hospital Clínico Universitario de Valladolid
2012
Parc Sanitari Sant Joan de Déu
2011
African swine fever is a highly contagious viral disease of mandatory declaration to the World Organization for Animal Health (OIE). The lack available vaccines makes its control difficult; thus, virus (ASFV) represents major threat industry. Inactivated do not confer solid protection against ASFV. Conversely, live attenuated viruses (LAV), either naturally isolated or obtained by genetic manipulation, have demonstrated reliable homologous ASFV strains, although little no has been...
African swine fever (ASF) has become the major threat for global industry. Furthermore, epidemiological situation of virus (ASFV) in some endemic regions Sub-Saharan Africa is worse than ever, with multiple strains and genotypes currently circulating a given area. Despite recent advances on ASF vaccine development, there are no commercial vaccines yet, most promising prototypes available today have been specifically designed to fight genotype II Europe, Asia, Oceania. Previous results from...
African swine fever (ASF) is today′s number one threat for the global industry. Neither commercial vaccine nor treatment available against ASF and, thus far, only live attenuated viruses (LAV) have provided robust protection lethal virus (ASFV) challenge infections. Identification of ASFV proteins inducing protective immune responses major challenges to develop safer and efficient subunit vaccines. Immunopeptidomic studies recently performed in our laboratory allowed identifying antigens...
Live attenuated vaccines are considered to be the fastest route development of a safe and efficacious African swine fever (ASF) vaccine. Infection with naturally OURT88/3 strain induces protection against challenge virulent isolates from same or closely related genotypes. However, adverse clinical signs following immunisation have been observed. Here, we attempted increase safety profile by deleting I329L, gene previously shown inhibit host innate immune response. The resulting virus,...
The development of subunit vaccines against African swine fever (ASF) is mainly hindered by the lack knowledge regarding specific ASF virus (ASFV) antigens involved in protection. As a good example, identity ASFV-specific CD8+ T-cell determinants remains largely unknown, despite their protective role being established long time ago. Aiming to identify them, we implemented IFNγ ELISpot as readout assay, using effector cells peripheral blood mononuclear (PBMCs) from pigs surviving experimental...
Abstract African swine fever virus (ASFV) is the causative agent of a devastating hemorrhagic disease (ASF) that affects both domestic pigs and wild boars. Conversely, ASFV circulates in subclinical manner pigs, including warthogs, natural reservoir for ASFV. Together with genetic differences, other factors might be involved differential susceptibility to ASF observed among Eurasian suids ( Sus scrofa ) warthogs Phacochoerus africanus ). Preliminary evidence obtained our laboratory others,...
Introduccion y objetivos: Pocos son los estudios que evaluan la autopercepcion del estigma social en las personas padecen esquizofrenia. El objetivo presente estudio consiste analizar percepcion sobre esquizofrenia tienen padecen. Material metodos: Se realizaron dos sesiones cuatro grupos focales de con estaban siendo atendidas servicios rehabilitacion psicosocial Parc Sanitari Sant Joan Deu. A partir un guion establecido se valoraron total 11 areas abordadas grupos. Resultados: Las...
African swine fever (ASF) has become the major threat to global industry. Lack of available commercial vaccines complicates implementation control strategies. So far, only live attenuated ASF viruses (ASFV) have demonstrated solid protection efficacy at experimental level. The molecular techniques allowed generation a collection deletion mutants lacking ASFV-specific virulence factors, some them with promising potential as vaccine candidates against pandemic genotype II ASFV strain currently...
Abstract Background Chronic kidney disease progression has been linked to pro-inflammatory cytokines and markers of inflammation. These are also elevated in end-stage renal (ESRD), which constitutes a serious public health problem. Objective To investigate whether single nucleotide polymorphisms (SNPs) located genes related immune inflammatory processes, could be associated with ESRD development. Design methods A retrospective case-control study was carried out on 276 patients 288 control...
CYP27B1 hydroxylase is a mitochondrial P450 enzyme, which catalyzes the metabolization of 25- hydroxyvitamin D3 to 1,25(OH)2 D3, most active natural vitamin D metabolite. 1,25(OH)2D3 plays role in regulation autoimmunity and cell proliferation. Its autoimmune disease was demonstrated. We therefore investigated two single nucleotide polymorphisms (SNPs) gene for an association with Addison's disease. One hundred twenty four patients three healthy controls were genotyped promoter (-1260) C/A...
CYP24 hydroxylase is a cytochromo P450, which encoded by gene located on chromosome 20q13 and takes part in the vitamin D degradation cascade.