A5073429149- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- Pediatric health and respiratory diseases
- vaccines and immunoinformatics approaches
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Research on Leishmaniasis Studies
- Microbial infections and disease research
- Xenotransplantation and immune response
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Rabies epidemiology and control
- T-cell and Retrovirus Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Trypanosoma species research and implications
- Immune Response and Inflammation
- Diabetes and associated disorders
- Virology and Viral Diseases
Centre de Recerca en Sanitat Animal
2014-2022
Icahn School of Medicine at Mount Sinai
2019
Universitat Autònoma de Barcelona
2014-2017
African swine fever is a highly contagious viral disease of mandatory declaration to the World Organization for Animal Health (OIE). The lack available vaccines makes its control difficult; thus, virus (ASFV) represents major threat industry. Inactivated do not confer solid protection against ASFV. Conversely, live attenuated viruses (LAV), either naturally isolated or obtained by genetic manipulation, have demonstrated reliable homologous ASFV strains, although little no has been...
African swine fever is one of the most devastating pig diseases, against which there no vaccine available. Recent work from our laboratory has demonstrated protective potential DNA vaccines encoding three viral antigens (p54, p30, and hemagglutinin extracellular domain) fused to ubiquitin. Partial protection was afforded in absence detectable antibodies prior virus challenge, survival correlated with presence a large number hemagglutinin-specific CD8(+) T cells blood. Aiming demonstrate...
Early interactions of influenza A virus (IAV) with respiratory epithelium might determine the outcome infection. The study global cellular innate immune responses often masks multiple aspects mechanisms by which populations cells work as organized and heterogeneous systems to defeat infection, how counteracts these systems. In this study, we experimentally dissected dynamics IAV human epithelial cell interaction during early infection at single-cell level. We found that number viruses...
African swine fever virus (ASFV) is the causal agent of fever, a hemorrhagic and often lethal porcine disease causing enormous economical losses in affected countries. Endemic for decades most sub-Saharan countries Sardinia, risk ASFV-endemicity Europe has increased since its last introduction into 2007. Live attenuated viruses have been demonstrated to induce very efficient protective immune responses, albeit time protection was circumscribed homologous ASFV challenges. However, their use...
African swine fever (ASF) is a pathology of pigs against which there no treatment or vaccine. Understanding the equilibrium between innate and adaptive protective responses immune might contribute to development strategies ASFV. Here we compare, using proteomic approach, course in vivo infection caused by two homologous strains: virulent E75 attenuated E75CV1. Our results show progressive loss proteins day 7 post-infection (pi) with E75, reflecting tissue destruction. Many signal pathways...
The influenza A virus (IAV) nonstructural protein 1 (NS1) contributes to disease pathogenesis through the inhibition of host innate immune responses. Dendritic cells (DCs) release interferons (IFNs) and proinflammatory cytokines promote adaptive immunity upon viral infection. In order characterize strain-specific effects IAV NS1 on human DC activation, we infected DCs with a panel recombinant viruses same backbone (A/Puerto Rico/08/1934) expressing different proteins from avian origin. We...
Abstract Background Leishmaniases are a group of neglected tropical parasitic diseases, mainly affecting vulnerable populations countries with poor socioeconomic status. Development efficient vaccines is priority due to the increasing incidence drug resistance and toxicity current treatments. In search for safe protective vaccine human dog visceral leishmaniases, we analyzed suitability immunomodulatory sirolimus (SIR) boost preventive DNA against leishmaniasis. SIR an already marketed that...