A5045612691- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Salmonella and Campylobacter epidemiology
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
- Analytical chemistry methods development
- Electrochemical Analysis and Applications
- Advanced Proteomics Techniques and Applications
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Cancer Research and Treatments
- Catalysts for Methane Reforming
- Catalytic Processes in Materials Science
- Immunotherapy and Immune Responses
- Bacteriophages and microbial interactions
- Molecular Biology Techniques and Applications
- Catalysis and Oxidation Reactions
- T-cell and B-cell Immunology
- Probiotics and Fermented Foods
- RNA Interference and Gene Delivery
- Electrochemical sensors and biosensors
- Virus-based gene therapy research
- Microbial infections and disease research
University of Córdoba
2008-2022
Instituto de Agricultura Sostenible
2015-2018
Hospital Universitario Ramón y Cajal
2017
Consejo Superior de Investigaciones Científicas
1995-2015
University of Connecticut
2008-2013
Clean Energy (United States)
2010-2013
Cordoba University
2003-2012
University of Arkansas for Medical Sciences
2003-2005
African swine fever virus (ASFV) is the causal agent of fever, a hemorrhagic and often lethal porcine disease causing enormous economical losses in affected countries. Endemic for decades most sub-Saharan countries Sardinia, risk ASFV-endemicity Europe has increased since its last introduction into 2007. Live attenuated viruses have been demonstrated to induce very efficient protective immune responses, albeit time protection was circumscribed homologous ASFV challenges. However, their use...
Recent progress in mammalian cell culture process has resulted significantly increased product titers, but also a substantial increase process- and product-related impurities. Due to the diverse physicochemical properties of these impurities, there is constant need for new technologies that offer higher productivity improved economics without sacrificing robustness required meet final drug substance specifications. Here, we examined use synthetic adsorptive hybrid filters (AHF) modified with...
The enteropathogen Salmonella Typhimurium (S. Typhimurium) is the most commonly nontyphoideal serotype isolated in pig worldwide. Currently, one of main sources human infection by consumption pork meat. Therefore, prevention and control salmonellosis pigs crucial for minimizing risks to public health. aim present study was use isobaric tags relative absolute quantification (iTRAQ) explore differences response two segment porcine gut (ileum colon) along a time course 1, 2 6 days post (dpi)...
A parametric study is presented to highlight design challenges of thermally integrated microchannel networks for portable chemistry and/or fuels reforming. One-dimensional modeling analysis heat transfer in a two-fluid system the case (i) two nonreacting fluids (heat exchanger), (ii) single exothermic reacting fluid and second (regenerative combustor), (iii) one endothermic exchanger reactor). In each case, influence solid-phase thermal conductivity packaging upon efficiency, reaction...
Porcine circovirus type 2 (PCV2) has been identified as the essential causal agent of postweaning multisystemic wasting syndrome. However, little is known regarding mechanism(s) underlying pathogenesis PCV2-induced disease and interaction virus with host immune system. Here, we present a proteomics study on inguinal lymph nodes piglets inoculated PCV2, in order to better understand syndrome pathways might be affected after infection. We used two strategies, 2-DE 1-DE followed by (16)O/(18)O...
African swine fever (ASF) is a pathology of pigs against which there no treatment or vaccine. Understanding the equilibrium between innate and adaptive protective responses immune might contribute to development strategies ASFV. Here we compare, using proteomic approach, course in vivo infection caused by two homologous strains: virulent E75 attenuated E75CV1. Our results show progressive loss proteins day 7 post-infection (pi) with E75, reflecting tissue destruction. Many signal pathways...
In this paper, we present the protein map corresponding to porcine peripheral blood mononuclear cells (PBMC) better understand role of these in pig immune system. To conform map, proteins were separated by 2-DE using a 5–8 range pH gradient IEF and approximately 800 spots detected. Due high level indeterminate variability associates 2-DE, analytical biological variances analyzed. The variance was calculated for 50 three replicate gels from same extract whereas determined comparison patterns...
Campylobacter jejuni is the leading food-borne poisoning in industrialized countries. While bacteria causes disease humans, it merely colonizes gut poultry or pigs, where seems to establish a commensal relationship. Until now, few studies have been conducted elucidate relationship between C. and its different host. In this work, comparative proteomics approach was used identify underlying mechanisms involved divergent outcome following infection human porcine Human (INT-407) (IPEC-1)...
Human gpIIb‐IIIa or CD41/CD61 is a Ca 2+ ‐complex dependent heterodimer, abundant on platelets, that plays key role in hemostasis. This report describes murine monoclonal antibody, JM2E5, able to recognize and immunoprecipitate the gpIIb/IIIa surface glycoprotein from porcine platelets. Immunoprecipitation analysis showed an antigen molecular weight of 115 85 kDa under nonreducing conditions, 110, 100 25 reducing conditions. Immunohistochemistry analyses frozen sections several lymphoid...
In this work, the authors design, fabricate, and evaluate three prototype ceramic microchannel reactor architectures with two-dimensional complex flow configurations for coupling methanol steam reforming combustion/partial oxidation. These prototypes were evaluated autothermal hydrogen production from in order to investigate influence of individual process rates radial distribution schemes upon thermal gradients overall system performance absence any external insulation. Results demonstrate...