A5101544382- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Epigenetics and DNA Methylation
- Soil Carbon and Nitrogen Dynamics
- Soil erosion and sediment transport
- Conservation Techniques and Studies
- Renal and related cancers
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Forest ecology and management
- Building materials and conservation
- Chronic Kidney Disease and Diabetes
- Erythropoietin and Anemia Treatment
- Acute Kidney Injury Research
- RNA modifications and cancer
- Iron Metabolism and Disorders
- Phytochemical compounds biological activities
- Rangeland Management and Livestock Ecology
- Regulation of Appetite and Obesity
- Drug-Induced Hepatotoxicity and Protection
- Renal Diseases and Glomerulopathies
- Conservation, Biodiversity, and Resource Management
- Phytochemical Studies and Bioactivities
Central Hospital of Wuhan
2025
Hainan University
2025
West China Hospital of Sichuan University
2022-2024
Sichuan University
2022-2024
General Hospital of Central Theater Command
2024
Yan'an University
2022-2023
Lanzhou University
2015-2023
Yunnan Agricultural University
2023
Northeastern University
2022
Guangzhou Huashang College
2022
Abstract Histone lysine crotonylation (Kcr), as a posttranslational modification, is widespread acetylation (Kac); however, its roles are largely unknown in kidney fibrosis. In this study, we report that histone Kcr of tubular epithelial cells abnormally elevated fibrotic kidneys. By screening these crotonylated/acetylated factors, crotonyl-CoA-producing enzyme ACSS2 (acyl-CoA synthetase short chain family member 2) found to remarkably increase 3 9 (H3K9cr) level without influencing H3K9ac...
The systemic immune-inflammation index, a new index based on platelets, neutrophils and lymphocytes, has been shown to be associated with outcomes of patients venous sinus thrombosis cancer. However, its application in acute ischemic stroke rarely reported. Therefore, we examined the relationship between levels at hospital admission 3 months after onset, plotted nomogram predict probability adverse stroke.We retrospectively analyzed total 208 who were admitted January 2020 December 2020,...
In this study, we compared the microbial communities colonising ancient cave wall paintings of Mogao Grottoes exhibiting signs biodeterioration. Ten samples were collected from five different caves built during time periods and analysed using culture-independent culture-dependent methods. The clone library results revealed high diversity, including bacterial groups Firmicutes, Proteobacteria, Actinobacteria, Acidobacteria, Cyanobacteria, Bacteroidetes, Gemmatimonadetes, Planctomycetes...
Unmanned aerial vehicles (UAVs) are increasingly used in instant delivery scenarios. The combined of and UAVs has many advantages compared to their respective separate delivery, which can greatly improve efficiency. Although a few studies the literature have explored issue vehicle-assisted UAV we did not find any on scenario an serving several customers. This study aims design new solution that allows serve multiple customers single take-off takes energy consumption into account. A multi-UAV...
Delayed wound healing is a common and serious complication in diabetic patients, especially the slow of foot ulcers, which seriously affects quality life patients also most important risk factor for lower limb amputation. The multifunctional novel dressing prepared by loading polymer nanofibers with anti-inflammatory prohealing plant extracts can promote repair these ulcers electrospinning technology. Liposomes are nanoparticles from phospholipids have been widely used as drug delivery...
Background: In preliminary research and literature review, we identified a potential link between chronic obstructive pulmonary disease (COPD) lipid metabolism. Therefore, this study employed Mendelian randomization (MR) analysis to investigate the causal connection blood lipids COPD. Materials Methods: A genome-wide association (GWAS) on COPD was conducted, encompassing total of 112,583 European participants from MRC-IEU. Additionally, extensive UK Biobank data pertaining profiles within...
Lumbar disc herniation (LDH) significantly impacts individuals, particularly those aged 40-45. Traditional Chinese Medicine (TCM) formulations such as Taohong Siwu Decoction (TSD), Yaotong Jizheng (YJD), and Panlong Qi Tablet (PQT) are widely used for treatment. This study introduces dose-weighted network pharmacology, a novel approach that incorporates drug dosage quantitative factor into analysis to evaluate better compare the therapeutic potential of TCM formulations. combines with PPI...
Reforestation has been widely considered to best solve this problem, but requires an accurate estimation of carbon stocks in the forest aboveground biomass (AGB) at a large scale. AGB models based on traits and remote sensing indices (moisture vegetation index (MVI)) are two good methods for purpose. But limited studies have developed them estimate stock during restoration degraded mining areas. Here, we successfully addressed challenge as trait-based MVI-based after performing reforestation...
13 quinic acid derivatives along with caffeic acid, methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract of flower buds Lonicera bournei Hemsl., among which 8 compounds firstly obtained this genus. The effects different solvent soluble fractions pure on heptocyte death induced by D-galactosamine (D-GalN)/tumor necrosis factor α (TNF-α) studied, structure-activity relationships also discussed.
The tumor necrosis factor alpha (TNF-α)-TNF-α receptor (TNFR) interaction plays a central role in the pathogenesis of various autoimmune diseases, particularly rheumatoid arthritis, and is therefore considered key target for drug discovery. However, natural compounds that can specifically block TNF-α-TNFR are rarely reported. (-)-Epigallocatechin-3-gallate (EGCG) most active, abundant, thoroughly investigated polyphenolic compound green tea. molecular mechanism by which EGCG ameliorates...
The selection of suitable tree species and the reasonable allocation planting areas are important measures for improving soil quality. This study aimed to investigate characteristics typical vegetation type quality differences their dominant factors in loess hilly–gully after returning farmland forest (grassland). status arbors, shrubs grasslands area were comprehensively analyzed using index (SQI) structural equation modeling (SEM). results showed following: (1) In area, shrub had a high...
Abstract Accelerating the construction of ecological civilization in industrial field and guiding transformation industry toward a green direction have become national development strategy. Promoting coordinated energy‐intensive industries such as steel, cement, power is key breakthrough achieving various industries. This study has designed steel–cement–power polygeneration system with collaborative utilization solid waste resources link point. Four scenarios, including business‐as‐usual,...
In a complete organic ecosystem restoration in mining areas, soil and vegetation complement influence each other. It is of great significance to evaluate the ecological effect on stability area, with coupling coordinating relationship between herb community physicochemical properties after land reclamation. Therefore, this study takes Juxinlong Coal Mine Dongsheng District Ordos City, Inner Mongolia Autonomous Region as area. The understory herbaceous plant factors time 3 7 years were...
Choosing economically important trees and establishing planting patterns can improve soil quality in economic forests. To clarify the status of main forest land distributed northern Shaanxi, research object this study was jujube apple forests, control grassland. By evaluating 17 indicators, minimum data set (MDS) structural equation model (SEM) were used to analyze its dominant factors under different forests preparation methods. The results showed that (1) compared with grassland, has a...
Microbial colonization represents one of the main threats to conservation subterranean cultural heritage sites. Recently, microbial on murals in tombs has gradually attracted attention.In this study, a total 33 samples, including 27 aerosol samples and 6 mural painting were collected from different sites Xu Xianxiu's Tomb analyzed using culture-dependent methods. We compared diversities culturable bacteria fungi isolated air explored potential impacts microorganisms biodeterioration...
Human resource management involves a variety of data processing, and the process is complicated. In order to improve effect human management, this paper combines BP neural network logistic regression analysis construct an intelligent system uses backpropagation learning adjust training errors determine connection weights. Moreover, estimates probability certain event through analysis, predicts analyzes process, builds with support joint algorithms. explore reliability algorithm proposed in...
Strain AFT2T was isolated from a mural painting sample ca. 1500-year-old tomb located in Shanxi Province, China. The isolate Gram-stain-positive, non-motile, non-spore-forming, aerobic and oval to short-rod-shaped bacterium that formed white-pigmented colonies. Phylogenetic analyses based on 16S rRNA gene sequence revealed strain most closely (97.01 %) correlated monophyletic clade with Naumannella halotolerans WS4616T (=DSM 24323T). G+C content of the genomic DNA 71.97 mol%, showed 37.27 %...
This study aims to explore circ_0058063 effect on multiple myeloma cells malignant phenotype and its feasible mechanism.We selected 47 cases of tissues normal bone marrow then used RT-qPCR method test miR-635 expression in the tissues. Myeloma RPMI8226 were transfected with si-circ_0058063, mimic, si-circ_0058063 + anti-miR-635, respectively. Then, we adopt CCK-8 method, flow cytometry Transwell western blot methods detect influences knockdown or overexpression cell proliferation, apoptosis,...
Abstract Background and Aims Age-related changes in kidney function, structure, their relationships have been extensively recognized recently. Here, we report that acyl-CoA synthetase short chain family member 2 (Acss2) as a regulator of lipid metabolism, play an important role age-associated renal fibrosis. Method 21-month-old Acss2 knockout (Acss2−/−) mice were used the aging models, H2O2 also was to induced tubular epithelial cells (TCMK-1) senescence. Serum creatinine (Cr) urinary...
Abstract Background and Aims The efficacy of roxadustat combined with erythropoiesis-stimulating agent (ESA) on renal anemia in maintenance hemodialysis (MHD) patients is rarely reported, especially for those ESA hyporesponsiveness. Our study aimed to observe the short-term when they were first treated converted from ESA. Method Retrospective data pertaining MHD hyporesponsiveness September 2019 June 2022 collected. All had been more than 6 months roxadustat. 19 alone paired analysis 108 by...