A5101514872- Hepatitis B Virus Studies
- Blood donation and transfusion practices
- Hepatitis C virus research
- Blood groups and transfusion
- Acute Lymphoblastic Leukemia research
- Blood transfusion and management
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Sesquiterpenes and Asteraceae Studies
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Retinoids in leukemia and cellular processes
- Platelet Disorders and Treatments
- HIV, Drug Use, Sexual Risk
- NF-κB Signaling Pathways
- Organ Donation and Transplantation
- Cytomegalovirus and herpesvirus research
- Electrospun Nanofibers in Biomedical Applications
- T-cell and B-cell Immunology
- Circular RNAs in diseases
Shahid Beheshti University of Medical Sciences
2015-2024
Shahid Beheshti University
2020-2023
Glenfield Hospital
2023
Iranian Legal Medicine Organization
2004-2013
High Institute for Education and Research in Transfusion Medicine
2006-2013
Baqiyatallah University of Medical Sciences
2012
Burnley General Teaching Hospital
2011
Iran University of Medical Sciences
2010
National Blood Transfusion Service
2008
Southmead Hospital
2002-2004
The most prominent capabilities of mesenchymal stem cells (MCSs) which make them promising for therapeutic applications are their capacity to endure and implant in the target tissue. However, these limited due early death within first few days following transplantation. Therefore, improve cell therapy efficacy, it is necessary manipulate MSCs resist severe stresses imposed by microenvironment. In this study, we manipulated express a cytoprotective factor, nuclear factor erythroid-2 related 2...
Abstract Background: There is significant interest in using nanofibers tissue engineering from stem cells. The transdifferentiation of mesenchymal cells into the hepatic lineage a nanofibrous structure has not been reported. In this study, three dimensional scaffold introduced for differentiation human bone marrow derived (hBMSCs) hepatocytes. Methods: A composed Poly (ε‐caprolactone), collagen and polyethersulfone was fabricated by electrospinning technique. After characterization isolated...
Abstract Background and Objectives Nucleic acid amplification testing (NAT), in blood services context, is used for the detection of viral parasite nucleic acids to reduce transfusion‐transmitted infections. This project reviewed NAT screening donations globally. Materials Methods A survey on usage, developed by International Society Blood Transfusion Working Party Transfusion‐transmitted Infectious Diseases (ISBT WP‐TTID), was distributed through ISBT WP‐TTID members. Data were analysed...
summary . Knowledge of physicians has an important role in optimal use blood products. This study was carried out to assess Iranian physicians' knowledge transfusion medicine. In this cross‐sectional study, 1242 were selected through multistage sampling method March 2007. Physicians' assessed by the questionnaire comprising 50 questions addressing basic knowledge, clinical aspects and reactions. One point awarded for each correct answer. Approximately 22%, 37%, 40% referring reactions,...
Seroepidemiological surveys show that the prevalence of human herpesvirus 8 (HHV-8) infection mostly varies in various geographical areas and reflects local incidence classic endemic KS, being widespread sub-Saharan Africa Mediterranean countries uncommon USA Northern Europe. In Middle East only few populations, such as Ashkenazi Sephardic groups Israel, have been adequately evaluated for HHV-8 seroprevalence. Among Iranian population a striking higher seroprevalence HHV8 has reported among...
Abstract Acute myeloid leukemia represents a group of malignant blood disorders that originate from clonal over-proliferation and the differentiation failure hematopoietic precursors, resulting in accumulation blasts bone marrow. Mesenchymal stromal cells (MSCs) have been shown to exert diverse effects on tumor through direct indirect interaction. Exosomes, as one means intercellular communication, are released different types cells, including MSCs, their various contents, such lncRNAs,...
Objectives The aim of this study was to find out substitution effect fetal bovine serum (FBS) with human platelet releasate (HPR) as a major growth factor source during expansion and differentiation bone marrow‐derived mesenchymal stem cells (hBMSC) into hepatocytes. Methods Propagation potential hBMSCs hepatocyte‐like in medium fortified HPR instead FBS were investigated morphological, cytochemical molecular experiments. Results Multiplex analysis showed that more efficient than supporting...
Treatment guidelines contraindicate ribavirin for treatment of hepatitis C virus (HCV) infection in thalassemia major patients. Nevertheless, the current evidence suggests that might be tolerated by these patients.Despite this evidence, low dose combination therapy has not been compared with peginterferon monotherapy patients so far.Two hundred eighty detectable HCV-RNA PCR (≥ 50 IU/mL) and liver histology consistent chronic HCV were self-assigned to receive alfa-2a (n = 81) or its...
The novel coronavirus (SARS-Cov-2) that was first reported in Wuhan, China, and provokes the COVID-19 disease has developed into a pandemic with hundreds of thousands people infected. Many governments have enforced social isolation protocols on their citizens, which led to closure many large public gatherings order limit spread virus. These closures could reasonably be expected affect blood collections, thereby presaging shortages for transfusion. On other hand, steps such as postponement...
Since chemotherapy drugs have dose-related side effects, there is still a need for finding new agents with suitable cytotoxic effects without any harmful effects. For this purpose, we evaluated the of Britannin that Sesquiterpene Lactone compound Inula aucheriana, alone or in combination Vincristine (VCR), on Acute Lymphoblastic Leukemia (ALL)-derived MOLT-4 cells. In study, found decreased viability cells IC50 Values 2 µM, but had no normal Peripheral Blood Mononuclear Cells (PBMCs). Our...
Aim To supporting growth and functional differentiation of adult stem cells into hepatocytes in a well-controlled manner, we performed human bone marrow mesenchymal (hBMSCs) to hepatocytes-like on constructed 3-dimensional (3D) nanofibrous biocompatible scaffold. Methods After characterization the hBMSCs isolated from marrow, performance seeded their proliferation scaffold was evaluated by scanning electron microscopy (SEM) 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT)...
Iranian Blood Transfusion Organization (IBTO) is the only nationally accredited organization in Iran that performs blood transfusion procedures ranging from donor recruitment as well distribution. IBTO was established May 1974. This government-based provides its services free of charge. Before establishment, were provided through hospital-based systems. managed by Supreme Council, which consists five experts hematology and related fields appointed Minister Health. The Managing Director IBTO,...