Thyroid hormones have a pivotal role in controlling metabolic processes, cardiovascular function, and autonomic nervous system activity. Hypothyroidism, prevalent endocrine illness marked by inadequate production of thyroid hormone, has been linked to different abnormalities, including alterations heart rate variability (HRV). The study included 110 patients with hypothyroid disorder. Participants underwent clinical assessments, function tests HRV analysis. HRV, measure the variation time...

Background and Objectives: Heart failure (HF) among patients with type 2 diabetes (T2DM) is linked to significant morbidity mortality, despite the increased availability of new drug therapy. This study aims investigate subclinical changes in HF stage A (at risk for HF) B (Pre-HF) T2DM treated oral semaglutide. Materials Methods: In a prospective, observational, single-center study, 50 were assessed at baseline one-year follow-up spectral Doppler, tissue speckle-tracking (2DST) metabolic...

Introduction Acute kidney injury (AKI) increases the risk of death in acute ischemic stroke (AIS) patients. Intravenous thrombolytic therapy (iv. rt-PA) seems to be most effective treatment for AIS The effects AKI on iv. rt-PA treated cases is less studied. Our paper addresses this issue. Methods 45 consecutive patients with (median age = 64 years; 29 male) and 59 sex matched controls not eligible have been enrolled our study. Subjects were followed-up until hospital release or follow up...

Monoamine oxidases (MAOs) are mitochondrial enzymes with 2 isoforms that have emerged as important contributors to cardiovascular oxidative stress via the constant generation of hydrogen peroxide. The present study was purported assess whether MAO-derived H2O2 contributes endothelial dysfunction in mammary arteries harvested from coronary heart disease patients and without diabetes mellitus subjected artery bypass grafting. To this aim, effects MAO inhibition on vascular contractility...

: Heart rate variability (HRV) is the fluctuation in time intervals between adjacent heartbeats. HRV a measure of neurocardiac function that produced by dynamic autonomic nervous system (ANS) processes and simple estimates cardiac modulation.

Fine needle aspiration (FNA) is considered the gold standard in diagnostic of thyroid nodules. Using recommended BETHESDA reporting system, up to 20% results are classified as intermediate cytology. As there no consensus whether ultrasound evaluation, lobectomy or surgery best treatment option, cytology a grey zone FNA. The main aim our study was evaluate performance combined advanced techniques process diagnosis and evaluation cases after We evaluated 54 consecutive with on FNA, using...

The important prevalence of autoimmune thyroid disease (AITD) in the general population was main motivation for conducting present study. paper aims to estimate possible comorbidities related female sexual dysfunction (FSD) and depression AITD. study group consisted 320 patients: 250 cases known with untreated AITD, divided into subgroups (euthyroid subgroup, subclinical hypothyroidism subgroup clinical subgroup); respectively 70 healthy females control group. Patients underwent evaluation,...

Chronic autoimmune thyroiditis (CAT) is the most common thyroid disorder in pediatric population. Ultrasound evaluation may suggest diagnosis. Additionally, shear-wave elastography (SWE) proved to be a valuable additional diagnosis tool adults with CAT by assessing stiffness (TS). This study aims assess its use also detecting children CAT. The group consisted of 50 confirmed CAT, who were compared control group, consisting no pathology and an adult subjects included, besides...

Introduction Kidney dysfunction is prevalent in oncology patients and has an impact on their treatment quality of life. The aim our study was to analyze the prevalence CKD a large cohort several types cancer East European Region. Material methods We conducted observational retrospective 5831 consecutive, biopsy-diagnosed between January 2019 –December 2020 largest hospital outpatient clinic Western Romania. 4342 subjects were included statistical analysis. Results discussion From 24 types,...

Background/aims: Prior research identified a significant association between heart disease and metabolic dysfunction-associated liver steatohepatitis (MASLD), but the mechanisms are unclear. This study aims to search predictive biomarkers for grade I left ventricular diastolic dysfunction (LVDD), an early stage of failure (HF), in type 2 diabetes mellitus (T2DM) patients. Methods: single-center, prospective observational screened 73 T2DM patients 1 LVDD MASLD using 2D echocardiography,...

Despite the notable advancements witnessed in past decade medical and health research domain, cancer remains a prominent global cause of mortality. Moreover, conventional treatments employed to combat this disease have been found considerably compromise quality life experienced by patients due its severe side effects. Recent vitro studies revealed encouraging findings on potential beneficial effects probiotics as adjuvants anticancer therapy, even possible agents for prevention treatment...

Chronic kidney disease patients treated by hemodialysis present a high cardio-vascular morbidity and mortality. There is an imperative need for novel biomarkers in identifying to offer possible therapeutically intervention these patients. We performed prospective observational cohort study on 77 the period October 2021 – 2023. measured serum plasma levels of Interleukin 1-Beta, Galectin 3, human suppression tumorigenicity factor 2, bone morphogenetic protein 2 fibroblastic growth...

Background: Acute kidney disease (AKD) is a known risk factor for increased mortality and evolution towards chronic (CKD) in adults. The data regarding children are scarce. purpose of our study to explore the AKD impact following an acute injury (AKI) episode on new-onset CKD. Methods: We retrospectively evaluated 736 with ages between 2 18 years old AKI admitted tertiary care hospital from west Romania over 9 period. Results: incidence was 17%. Patients that developed were older, higher...

The increase in bacterial resistance is currently a global burden for the health care system. In order to evaluate rates of several bacteria from most encountered cultures clinical practice, we performed retrospective analysis all positive year 2021 tertiary hospital Romania. Our captured 3299 cultures. median age patients was 62 years (IQR: 41-71 old) with slight predominance among females (53.1%). Overall, common were urocultures, wound secretion and blood cultures, identified

(1) Background: Pregnancy induces significant physiological adaptations with substantial impacts on the cardiovascular system. Hypertensive disorders of pregnancy (HDPs) are connected to risks maternal and fetal complications, contributing significantly morbidity mortality across globe. This study focuses evaluating autonomic dysfunction by analyzing heart rate variability (HRV) assessing cardiac performance through global longitudinal strain (GLS) using speckle tracking echocardiography, as...

Background/Objectives: Prior research has identified a significant association between heart disease and metabolic-dysfunction-associated steatotic liver (MASLD); however, the underlying mechanisms are unclear. This study aimed to identify predictive biomarkers associated with grade I left ventricular diastolic dysfunction (LVDD) in patients type 2 diabetes mellitus (T2DM). Methods: single-center, cross-sectional evaluated 73 T2DM for 1 LVDD MASLD using 2D echocardiography, tissue analysis,...

Betulinic acid (BA) has been extensively studied in recent years mainly for its antiproliferative and antitumor effect various types of cancers. Limited data are available regarding the pharmacokinetic profile BA, particularly metabolic transformation vivo. In this study, we present screening structural investigations by ESI Orbitrap MS negative ion mode CID MS/MS phase I II metabolites detected mouse plasma after intraperitoneal administration a nanoemulsion containing BA SKH 1 female mice....

Aim: Current major guidelines recommend risk stratification of the thyroid nodules, after each diagnostic evaluation, in order to focus attention on potentially risky nodules. The main aim our study was evaluate performance combined advanced ultrasound techniques this process, compared with conventional models, reduce unnecessary fine-needle biopsies, respectively, surgery. Material and Methods: We evaluated 261 cases (261 nodules) using (2B), real-time Doppler evaluation (4D) elastography,...

One of several promising strategies for increasing the bioavailability and therapeutic potential high-lipophilic biologically active compounds is gold nanoparticle formulation. The current study describes synthesis biological antimelanoma evaluation three triterpen-functionalized nanoparticles, obtained using our previously reported benzotriazole-triterpenic acid esters. Functionalized (GNP) formation was validated through UV-VIS FTIR spectroscopy. conjugate's cytotoxic effects were...

Introduction East-European data on cancer in patients undergoing hemodialysis (HD) are scarce. This study aimed to assess the pattern of and related mortality with end-stage kidney disease (ESKD) HD.Methods Retrospectively analyzing from 7 HD centers, this examined 1377 incident divided into three groups: no-cancers (NoC), cancers that occurred prior initiation (CPI) de novo developed after (DNC). Mortality risk survival trends within groups were analyzed using Cox regression Kaplan-Meier...

Acute respiratory syndrome-related coronavirus 2, or SARS-CoV-2, mainly affects the vulnerable population, especially those with comorbidities, such as pregnant women. SARS-CoV-2 has been found to cause multiple manifestations, one of which is preeclampsia. In preeclampsia, uric acid excessively produced in ischemic placenta and released into circulation by placental reperfusion. Another effect oxidative stress production oxygen free radicals associated severe preeclampsia fetal hypoxia. our...

Abstract Left ventricular (LV) structure and function anomalies are frequent during the CKD continuum associated with increased risk of mortality. Cross section longitudinal ultrasound data available for advanced transition to ESKD. Less information is about LV changes stable, long-term hemodialysis (HD) treatment. All stable HD patients from 9 centers (1034 patients, 671 males, age 58.71 ± 12.94 years) have been enrolled in January 2015. The cohort was followed-up 4 years, kidney...