A5088823734- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Ophthalmology and Visual Impairment Studies
- Ocular Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Biomedical Research and Pathophysiology
- Intraocular Surgery and Lenses
- Digital Imaging for Blood Diseases
- Optical Coherence Tomography Applications
- Hereditary Neurological Disorders
- Parasite Biology and Host Interactions
- Ocular and Laser Science Research
- Corneal surgery and disorders
- Ocular Oncology and Treatments
- Nuclear Receptors and Signaling
- Library Collection Development and Digital Resources
- Toxoplasma gondii Research Studies
- Advanced optical system design
- Advanced Glycation End Products research
- COVID-19 diagnosis using AI
- Adversarial Robustness in Machine Learning
University of Lausanne
2019-2025
Hôpital Ophtalmique Jules-Gonin
2019-2025
Fondation Asile des Aveugles
2019-2024
University College London
2010-2019
Moorfields Eye Hospital
2010-2019
Moorfields Eye Hospital NHS Foundation Trust
2009-2018
Institute of Ophthalmology
2013
University College Hospital
2009
Semmelweis University
2002-2005
We investigated abnormalities of the photoreceptor inner/outer segment (IS/OS) junction layer viewed "en face" and their functional correlates in type 2 idiopathic macular telangiectasia (type MacTel).Segmentation imaging IS/OS lines spectral domain optical coherence tomographic (SD-OCT) volumes were performed manually. Mesopic retinal sensitivity thresholds determined using a Nidek MP1 microperimeter. "En SD-OCT images microperimetric data superimposed over fundus. Retinal structure...
To document the progression of a break in photoreceptor inner segment/outer segment (IS/OS) junction layer and its functional correlates over time natural history type 2 idiopathic macular telangiectasia (type MacTel).Patients with at least 1 year follow-up were selected from MacTel Study. En face images created by manual segmentation IS/OS junctional line volume scans acquired using spatial-domain optical coherence tomography retinal imaging unit. Retinal sensitivity thresholds determined...
To evaluate progression of macular telangiectasia Type 2 lesions and their correlation with visual acuity.An international multicenter prospective study annual examinations including best-corrected acuity (BCVA), fundus photography, fluorescein angiography, optical coherence tomography images graded centrally. Mixed models were used to estimate rates, a generalized linear model compute the relative risk BCVA loss, loss ellipsoid zone (EZ) reflectivity, development pigment plaques, or...
<h3>Aims</h3> To quantitatively analyse cone photoreceptor matrices on images captured an adaptive optics (AO) camera and assess their correlation to well-established parameters in the retinal histology literature. <h3>Methods</h3> High resolution were acquired from 10 healthy subjects, aged 20–35 years old, using AO (rtx1, Imagine Eyes, France). Left eye at 5° of eccentricity, temporal fovea for consistency. In three also 0, 2, 3, 5 7° eccentricities. Cone density was calculated following...
Publicly available open-access OCT datasets for retinal layer segmentation have been limited in scope, often being small size, specific to a single disease, or containing only one grading. This dataset improves upon this with multi-grader and multi-disease labels training machine learning-based algorithms. The proposed covers three subsets of scans (Age-related Macular Degeneration, Diabetic Edema, healthy) annotations two types tasks (semantic object detection). compiled 5016 pixel-wise...
To report the early efficacy and safety outcomes of treatment with intravitreal injections brolucizumab (IVT-B) in patients presenting neovascular age-related macular degeneration (nAMD) a tertiary clinical setting. A retrospective case series that received IVT-B minimum two performed at least 4 weeks follow-up after last injection. Nineteen eyes 19 were included. The number for whole cohort was 58 injections; mean per patient 3.0 ± 1.0 (range 2-6); time 14.4 9.0 weeks. Mean baseline...
Abstract Purpose To investigate the progression characteristics of ellipsoid zone ( EZ ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, their relevance for visual acuity. Methods Participants were selected from MacTel Study cohort. Linear measurements performed Spectral‐Domain Optical Coherence Tomograph (SD‐OCT) volume scans. Progression correlations between analysed using mixed effects models. Results A total 134 70 patients included...
To develop a severity classification for macular telangiectasia type 2 (MacTel) disease using multimodal imaging.An algorithm was used on data from prospective natural history study of MacTel development.A total 1733 participants enrolled in an international MacTel.The Classification and Regression Trees (CART), predictive nonparametric machine learning, analyzed the features imaging important development classification, including reading center gradings following digital images:...
Macular telangiectasia Type 2 is a bilateral, progressive potentially blinding retinal disease characterized by both vascular and neurodegenerative signs that have been documented using different imaging techniques. The correlation between macular from various modalities unknown. Our aim was to investigate the relationship of fundus fluorescein angiography, optical coherence tomography dual-wavelength autofluorescence images.Participants were selected Natural History Observation Study, based...
Pigment in the midretina is a characteristic sign Type 2 idiopathic macular telangiectasia (MacTel) and considered to characterize late stage of disease. Our aim was investigate its incidence, relationship with risk factors for MacTel, including outer retinal vascularization subretinal neovascular proliferation (SRNV).Pigment extent measured fundus autofluorescence images 150 eyes 75 MacTel probands, using Region Finder tool Heidelberg Eye Explorer. A linear mixed model used analyze dynamics...
Macular telangiectasia type 2 (MacTel) is a rare, heritable and largely untreatable retinal disorder, often comorbid with diabetes. Genetic risk loci subtend vascular calibre glycine/serine/threonine metabolism genes. Serine deficiency may contribute to MacTel via neurotoxic deoxysphingolipid production; however, an independent contribution also suspected. Here, we use statistical genetics dissect the causal mechanisms underpinning this complex disease.We integrated genetic markers for...
<h3>Aims:</h3> To investigate the functional implications of macular soft drusen regression in AMD eyes. <h3>Methods:</h3> Patients were selected from a large ongoing collection clinical data at Moorfields Eye Hospital. Phenotyping based on standard colour fundus images was performed according to system defined by International Classification for ARM, certified graders masked main aim study. Fundus autofluorescence (FA) recorded using Heidelberg Retina Angiograph 2. Where confirmed...
Type 2 idiopathic macular telangiectasia (MacTel) is a progressive retinal disease associated with slow deterioration of visual acuity, starting in the fifth to seventh decades life. The etiology and pathogenesis are little known, no effective therapy available. We aimed estimate prevalence describe phenotype type MacTel two African populations.From population-based cross-sectional surveys conducted nationally Nigeria Nakuru district Kenya, patients fundus features were selected. Diagnosis...
Macular telangiectasia Type 2 is a bilateral, progressive, potentially blinding retinal disease characterized by both vascular and neurodegenerative signs. Both the area of break in ellipsoid zone seen "en face" optical coherence tomographic (OCT) images microperimetric focal sensitivity loss have been proposed as potential measures progression macular telangiectasia. The authors aimed to assess characteristics interrelationship these structural functional markers from data collected phase...
Purpose: Macular telangiectasia Type 2 (MacTel) is a bilateral, progressive, potentially blinding retinal disease characterized by vascular and neurodegenerative signs, including an increased parafoveal reflectivity to blue light. Our aim was investigate the relationship of this sign with other signs macular in multiple imaging modalities. Methods: Participants were selected from MacTel study, based on confirmed diagnosis availability images. The extent blue-light reflectance, fluorescein...
Purpose: To determine normative values for defining glaucoma in cross-sectional surveys Nigerian adults.
Purpose: To investigate the electrophysiological features of macular telangiectasia Type 2 and their relationship to structure as determined by optical coherence tomography imaging. Methods: Forty-two eyes from 21 patients enrolled in Macular Telangiectasia Natural History Observation Study were reviewed. All had full-field pattern electroretinography (ERG; PERG) with some additionally having multifocal (mfERG; N = 15) or electrooculography (N 12). Multiple linear regression modeling...
Purpose: To determine whether grading based on the International Classification (IC) for age-related macular degeneration (AMD) allows recognition of change during progression disease. Methods: Stereoscopic color fundus photographs 50 eyes 25 patients with AMD and at least 5 years review were graded in a random masked fashion changes over time characteristics drusen, pigmentary changes, end-stage disease, according to system defined by IC AMD, two independent graders (F.B.S., I.L.). Fundus...
Purpose: To characterize scotomas in macular telangiectasia Type 2 (MacTel). Methods: Five of the 27 centers performed microperimetry as part MacTel Natural History Observation Study. Data were analyzed Moorfields Eye Hospital Reading Centre. The number stimuli under a threshold 12, 10, 8, and <0 dB counted ( thresholding ) compared with one another. Results: A total 565 examinations gradable, received from 632 eyes 322 participants (age 61.1 ± 9.1 years, 62% females). authors found...