A5101482879- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- Pharmacological Effects of Natural Compounds
- Cancer Treatment and Pharmacology
- Renal and Vascular Pathologies
- Antibiotic Use and Resistance
- Electrochemical Analysis and Applications
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Cardiac pacing and defibrillation studies
- Phytochemistry and biological activity of medicinal plants
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Cardiovascular Effects of Exercise
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Food Science and Nutritional Studies
- Neuroscience and Neural Engineering
- Bioactive Compounds and Antitumor Agents
Quaid-i-Azam University
2018-2025
University of Szeged
2020-2024
Bacha Khan University
2024
University of Karachi
2024
Northeast Normal University
2023
Galveston College
2023
University of Novi Sad
2022
University of Peshawar
2021
University of Science and Technology Bannu
2021
Abdul Wali Khan University Mardan
2021
Neuroinflammation, oxidative stress and apoptosis are implicated in the pathogenesis of neuropsychiatric diseases like anxiety depression. 25-Methoxyhispidol A (25-MHA) is a triterpenoid isolated from immature fruit Poncirus trifoliate. Recently, its crude extracts have been shown to exhibit anti-bacterial anti-inflammatory activities. The current study investigated effect 25-MHA (1, 5 10 mg/kg) against bacteria-induced depression-like behaviors mice. Mice were challenged intraperitoneally...
The 2019 coronavirus disease (COVID-19) is a global pandemic with no therapy, and pharmacists being part of the health care system have vital role in management COVID-19. purpose this study to assess knowledge, attitude, practices community (CPs) regarding COVID-19.An online survey was conducted among 393 CPs 2 provinces Pakistan during lockdown period. A validated questionnaire (Cronbach's alpha, 0.745) used for data collection. All statistical analyses were analyzed by using SPSS, version...
This work aimed to develop lomustine (LOM) and n-propyl gallate (PG)-loaded liposomes suitable for targeting glioblastoma multiforme (GBM) via the auspicious nose-to-brain drug delivery pathway. The therapeutical effect of LOM, as a nitrosourea compound, can be potentiated by PG enhanced anti-cancer therapy. Nose-to-brain LOM combined in overcome poor water solubility, absorption properties, toxicity issues systemic circulation. Optimization characterization liposomal carrier with binary...
Abstract Cannabis use is associated with known cardiovascular side effects such as cardiac arrhythmias or even sudden death. The mechanisms behind these adverse are unknown. aim of the present work was to study cellular electrophysiological cannabidiol (CBD) on action potentials and several transmembrane potassium currents, rapid (I Kr ) slow Ks delayed rectifier, transient outward inward rectifier K1 currents in rabbit dog preparations. CBD increased potential duration (APD) significantly...
Cassia plants have a considerable position in conventional systems of medicine. The possible anti-nociceptive, anti-inflammatory, and anti-neuropathic properties artemisiodes (CAD) extract were tested using the standard animal models. In this study, vitro antioxidant, cyclooxygenase (COX-1 2), 5-lipoxygenase (5-LOX) inhibitory assays performed. anti-inflammatory activity was evaluated carrageenan, histamine, serotonin-induced paw edema Antipyretic activity, thermally chemically-induced...
The health benefits of regular physical exercise are well known. Even so, there is increasing evidence that the regimes elite athletes can evoke cardiac arrhythmias including ventricular fibrillation and even sudden death (SCD). mechanism exercise-induced arrhythmia SCD poorly understood. Here, we show chronic training in a canine model (12 sedentary 12 trained dogs) mimics regime induces electrophysiological remodeling (measured by ECG, patch-clamp, immunocytochemical techniques) resulting...
Abstract Amidst to current Coronavirus infectious disease 2019 (COVID-19) pandemic, the international pharmaceutical federation stated that pharmacists being a part of healthcare system had crucial role in management cycle COVID-19 outbreak. The purpose this study was assess knowledge, attitude and practice community pharmacists, snapshot their preparedness awareness regarding COVID-19. An online survey conducted among sample 393 from two provinces; Punjab Khyber-Pakhtunkhwa, Pakistan during...
Abstract Recent experimental data shows that hesperetin, a citrus flavonoid, affects potassium channels and can prolong the QT c interval in humans. Therefore, present study we investigated effects of hesperetin on various transmembrane ionic currents ventricular action potentials. Transmembrane current measurements potential recordings were performed by patch-clamp conventional microelectrode techniques dog rabbit preparations. At 10 µM concentration did not, however, at 30 significantly...
Abstract Enhancement of the late Na + current (I NaL ) increases arrhythmia propensity in heart, while suppression is antiarrhythmic. GS967 an agent considered as a selective blocker I . In present study, effects on and action potential (AP) morphology were studied canine ventricular myocytes by using conventional voltage clamp, clamp sharp microelectrode techniques. The (1 µM) compared to those class I/B antiarrhythmic compound mexiletine (40 µM). Under conditions, was significantly...
Abstract Neuropathic pain is an obstinate chronic state which extremely worsens the quality of life suffered population. It still intended as intractable disease existing therapies are not excellent in terms efficacy and tolerability. Therefore, to search for novel drugs crucial acquire satisfactory treatments. The present study investigated possible antiallodynic, antihyperalgesic neuroprotective activities (1,4-bis-(diphenylphosphino) butane) palladium (II)chloride monohydrate-( 1 )...