A5100461344- Antimicrobial Peptides and Activities
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Immune Cell Function and Interaction
- Lung Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Toxin Mechanisms and Immunotoxins
- Pediatric health and respiratory diseases
- Reproductive System and Pregnancy
- Bacterial Infections and Vaccines
- Peripheral Neuropathies and Disorders
- Venomous Animal Envenomation and Studies
- Bioinformatics and Genomic Networks
- Biochemical and Structural Characterization
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Cannabis and Cannabinoid Research
- Inflammatory mediators and NSAID effects
- Biomarkers in Disease Mechanisms
- Healthcare and Venom Research
- Leech Biology and Applications
- Gastric Cancer Management and Outcomes
- Ovarian function and disorders
- Galectins and Cancer Biology
Baylor College of Medicine
2022-2025
Shandong University of Traditional Chinese Medicine
2024
Third Affiliated Hospital of Southern Medical University
2024
Montefiore Medical Center
2023
Leibniz-Institut für Werkstofforientierte Technologien - IWT
2023
University of Bremen
2023
Shandong University
2021-2022
Shanghai University of Traditional Chinese Medicine
2022
Peking University
2020
Peking University Third Hospital
2020
Engineered microbes for the delivery of biologics are a promising avenue treatment various conditions such as chronic inflammatory disorders and metabolic disease. In this study, we developed genetically engineered probiotic system that delivers peptide to intestinal tract with high efficacy. We constructed an inducible in Lactobacillus reuteri secrete Kv1.3 potassium blocker ShK-235 (LrS235). show LrS235 culture supernatants block currents preferentially inhibit human T effector memory (T...
Background and aims: The increasing incidence of cardiovascular diseases has created an urgent need for safe effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, the effect promoting blood circulation removing stasis, but its real material basis mechanism action treatment such stasis thrombosis have not been reported. Methods: In this study, Whitmania Pigra Whitman (WPW), Hirudo nipponica (HNW) acranutata (WAW) were hydrolyzed by biomimetic enzymatic hydrolysis to...
Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components specifically target the tumors. We generated series copper-doped TiO2 nanoparticles order tune kinetics extent Cu2+ ion release from remnant nanocrystals. Fine-tuning nanoparticle properties resulted formulation 33% Cu-doped which enabled short-lived hyperactivation dendritic cells hereby...
The carcinogenesis mechanism of early-stage lung cancer (ESLC) remains unclear. Microbial dysbiosis is closely related to tumor development. This study aimed analyze the relationship between microbiota in ESLC. We investigated a total 108 surgical specimens nodules, including ground glass nodules (GGN) diagnosed as adenocarcinoma (n = 25), solid (SN) 27), squamous carcinoma (LUSC) presenting 26), and benign pulmonary (BPD) 30) that were collected. 16S rDNA amplicon sequencing non-targeted...
Objective This study aims to elucidate the mitigating effects of volatile oil Acori tatarinowii rhizoma (ATR) on dementia, in order provide a reference for future research and applications ATR field dementia. Materials methods A search strategy was developed using terms such as “Acori rhizoma,” “Acorus Schott,” “Asarone,” “Dementia.” The literature conducted PubMed, Web Science, Google Scholar, studies not meeting inclusion criteria were excluded. summarizes main metabolites, active...
Lupus nephritis (LN) is an autoimmune disease caused by systemic lupus erythematosus. Excessive proliferation of mesangial cells one the most serious pathological manifestations LN. In addition, expression PTX3 elevated in serum patients with Quercetin has good anti-inflammatory effects and immunomodulatory activities. this study, result MTT indicated that quercetin treatment alleviated excessive cells. ELISA immunofluorescence experiments showed inhibited PTX3. Three doses (20, 40, 80 μM)...
Chronic endometritis is a common disease in women of childbearing age and can cause pelvic inflammatory disease. The cGAS-STING pathway plays an important role many diseases.The aim this study was to investigate the relationship between endometritis.We collected endometrium samples from patients with detect changes pathway. In vitro, human endometrial stromal cells (HESC) were stimulated lipopolysaccharide (LPS), mouse STING gene-knockout model established by CRISPR/cas9 for further explore...
Increased serum IgE level is one of the features allergic asthma. It reported that production can be enhanced by E-prostanoid 2 (EP2) receptor prostaglandin E2 (PGE2); however, whether 4 (EP4) (encoded Ptger4) has a unique or redundant role still unclear. Here, we demonstrated mice with B cell-specific deletion EP4 (Ptger4 fl/fl Mb1 cre+/-) showed their levels were markedly increased. A much more severe airway inflammation was observed in absence signal using OVA-induced asthma model....
This study aimed to investigate the occurrence of Cytomegalovirus (CMV) DNA in Bronchoalveolar lavage fluid (BALF) children with recurrent wheezing and identify associations certain patient clinical characteristics. In this cross-sectional study, pediatric patients (age < 36 months) admitted Soochow University Hospital (≥ 4 episodes per year) were enrolled study. from their BALF was detected by real-time PCR. Subpopulations blood immunoglobulins T lymphocytes quantified. The characteristics...
Objective To construct a human leucocyte antigen (HLA)-A2-restricted peptide 278–286 of melanoma-associated family A, 1 (pMAGE-A1 ) tetramer to analyse the distribution cytotoxic T lymphocytes (CTLs) in tumour tissue and tumour-adjacent normal tissue. Methods A HLA-A2-pMAGE-A1 was constructed. The pMAGE-A1 -specific CTLs investigated tissues from patients with hepatocellular carcinoma using situ staining. Results Sodium dodecyl sulphate–polyacrylamide gel electrophoresis analysis indicated...
Esketamine (ESK), an intravenous anesthetic, exerts antidepressant effects; however, the antidepression mechanism is not clear. The aim of this study was to explore whether microglial cannabinoid type 2 (CB2) receptor and protein kinase C (PKC) are involved in effects ESK.
Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and severity of animal models autoimmune disease. Stichodactyla toxin (ShK), isolated from sea anemone helianthus , is a potent blocker Kv1.3. Several its analogs are some most selective blockers this channel. However, like biologics, ShK require injections for their delivery, repeated reduce patient compliance during treatment chronic diseases. We hypothesized that inducing expression an analog by hepatocytes...
Although anaplastic lymphoma kinase tyrosine inhibitors (ALK-TKIs) have impressive response in advanced lung adenocarcinoma with (ALK) fusion, no guidelines point to the potential benefits of neoadjuvant ALK-TKIs for N3 unresectable locally cancer. Current ongoing clinical trials mainly focus on efficacy resectable cancer and ignore role cancer.We report a case novel INTS10-ALK EML4-ALK rearrangement that achieved complete pathologic crizotinib. We conducted molecular analysis by using...
<b>Background:</b> Pertussis is an important cause of hospitalization in children. Limited data on pertussis have been reported from China. The aim this study was to characterize clinically suspected attributable Bordetella among children and determine factors associated with longer duration hospital stay infection. <b>Methods:</b> This prospective, observational enrolled hospitalized laboratory confirmed Children's Hospital Soochow University Jan 2016 through Aug 2017. Variables assessed...
目的 探讨儿童百日咳与类百日咳综合征的临床特点。 方法 收集2016年2月至2016年10月苏州大学附属儿童医院收治的58例疑似百日咳患儿的呼吸道分泌物，应用Real-time PCR检测百日咳杆菌双目标基因。 结果 入组患儿58例，PCR检测阳性患儿27例，阳性率46.6%；未接种百日咳疫苗的有19例(70.4%)。≤ 3月龄组阳性患儿有9例(33.3%)；>...
Abstract Engineered microbes for the delivery of biologics is a promising avenue treatment various conditions such as chronic inflammatory disorders and metabolic disease. In this study, we developed genetically engineered probiotic system that delivers small molecular biologic to intestinal tract with high efficacy minimized side effects. We constructed an inducible in Lactobacillus reuteri secret functional Kv1.3 potassium blocker ShK-235 (LrS235). show LrS235 capable blocking currents...
Abstract Qionggui Power (QP), a classic prescription in Traditional Chinese Medicine (TCM), has shown potential the treatment of atherosclerosis during past decades. However, mechanism that mediates these cardiovascular benefits remains to be fully elucidated. Here, we investigated effects and mechanisms QP against with network pharmacology approaches vitro model. The active ingredients related targets were collected from public databases. hub signaling pathways AS defined by extensive...
Abstract Background A sufficient endometrial thickness (EMT) is essential for successful pregnancy. For patients with a thin endometrium (EMT ≤7.5 mm on human chorionic gonadotropin [HCG] trigger day) in IVF, some studies have suggested freezing all embryos and preparing the subsequent frozen-thawed cycle, but not can obtain thicker during preparation frozen embryo transfer cycle than HCG day fresh cycle. This study aimed to investigate which characteristics of suggest possibility EMT...