A5020417110- COVID-19 Clinical Research Studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- Lung Cancer Research Studies
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Blood Pressure and Hypertension Studies
- Cannabis and Cannabinoid Research
- Anesthesia and Sedative Agents
- Metastasis and carcinoma case studies
- Stoma care and complications
- Neuroblastoma Research and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Graphene and Nanomaterials Applications
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- COVID-19 and healthcare impacts
- Pneumothorax, Barotrauma, Emphysema
- Gastrointestinal Bleeding Diagnosis and Treatment
- European and International Law Studies
- Enhanced Recovery After Surgery
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
Korea Research Institute of Bioscience and Biotechnology
2025
Icahn School of Medicine at Mount Sinai
2018-2024
Columbia University Irving Medical Center
2024
University of Pennsylvania
2021
Midwestern University
2015
Northwestern University
2015
Stony Brook University
2012-2013
Gastrointestinal cancer incidence varies by race and ethnicity. In the United States (US), there are screening guidelines for esophageal (EC) colorectal (CRC), but not gastric (GC). We compared GC, CRC, EC among most populous racial ethnic groups to inform US interception strategies.
Cancer stem cells (CSCs) contribute to the resistance of intractable prostate cancer, and dopamine receptor (DR)D2 antagonists exhibit anticancer activity against cancer CSCs. Human PC-3 were used generate CSC-like cells, serving as a surrogate system identify specific DR subtype inhibition which significantly affects prostate-derived Additionally, present study aimed determine downstream signaling molecules this that exert more profound effects compared with other subtypes. The inhibitory...
Abstract Background The prevalence and significance of digestive manifestations in COVID-19 remain uncertain. Methods Consecutive patients hospitalized with were identified across a geographically diverse alliance medical centers North America. Data pertaining to baseline characteristics, symptomatology, laboratory assessment, imaging, endoscopic findings from the time symptom onset until discharge or death manually abstracted electronic health records characterize prevalence, spectrum,...
<h3>Importance</h3> Although health care workers (HCWs) are at higher risk of acquiring coronavirus disease 2019 (COVID-19), it is unclear whether they poorer outcomes. <h3>Objective</h3> To evaluate the association between HCW status and outcomes among patients hospitalized with COVID-19. <h3>Design, Setting, Participants</h3> This retrospective, observational cohort study included consecutive adult a diagnosis laboratory-confirmed COVID-19 across 36 North American centers from April 15 to...
Asymptomatic blood pressure elevation is common in the inpatient setting. National guidelines recommend treating with oral agents to slowly decrease pressure; however, many clinicians use intravenous antihypertensive medications, which can lead unpredictable changes pressure.To number of inappropriate orders (without symptoms hypertensive emergency or order for NPO) antihypertensives and adverse events associated orders.Quasi-experimental study multidisciplinary intervention.Inpatients a...
Recent studies have suggested that proton pump inhibitor (PPI) use may increase the risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and worsen course COVID-19.1Almario C.V. et al.Am J Gastroenterol. 2020; 115: 1707-1715Crossref PubMed Scopus (146) Google Scholar,2Lee S.W. al.Gut. 2021; 70: 76-84Crossref (145) Scholar This observation is biologically plausible, as gastric acid a well-established line defense against microbial pathogens, including...
To evaluate the association between pre-hospitalization antiplatelet medication use and COVID-19 disease severity.
Abstract Background & Aims Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are heterogeneous neoplasms. Although some have a relatively benign and indolent natural history, others can be aggressive ultimately fatal. Somatostatin analogues (SSAs) improve both quality of life survival for these patients once they develop metastatic disease. However, drugs costly their cost-effectiveness is not known. Methods A decision-analytic model was developed analyzed to compare two treatment...
This Teachable Moment differentiates between hypertensive emergency and urgency examines the case of a woman who was incorrectly treated for when treatment would have been more appropriate.
Abstract Background Gastroenteropancreatic neuroendocrine tumors (GEP‐NETs) are increasingly common malignancies and tend to have favorable long‐term prognoses. Somatostatin analogues (SSA) a first‐line treatment for many NETs. Short‐term experiments suggest an association between SSAs hyperglycemia. However, it is unknown whether there relationship clinically significant hyperglycemia causing development of diabetes mellitus (DM), chronic condition with morbidity mortality. Aim In this...
Abstract Background: While gastric cancer (GC) incidence in the US has decreased, 5-year survival remains at 34.5%. Early diagnosis offers curative or treatable options, yet many cases are detected an advanced stage with poor prognosis. In high-incidence East Asian countries established screening programs, endoscopic demonstrates shift towards early GC and reduced GC-related mortality. Analyses of these programs have reported benefit up to 36 months prior diagnosis. This study explores...
Abstract not Available.
Abstract Glioblastoma multiforme (GBM) is fatal in nearly all instances, and responds poorly to current standards of care. GBMs exhibit resistance chemotherapy which leads tumor recurrence following initial surgical debulking. We have recently developed an 80 nm liposome containing a novel hydrophobic microtubule disrupting piperazine. This nanostructure, called IM-1 nanobin, contains 500-1000 piperazine drug molecules encapsulated the inner leaflet lipid bilayer each liposome. nanoparticle...
Background and Aims: Given the underlying properties of cannabinoids, we aimed to assess associations between cannabinoid use sedation requirements for esophagogastroduodenoscopy (EGD) colonoscopy.
Introduction: With an aging population, management of biologic therapy in IBD patients with active or recent cancer is challenging. We evaluated the comparative safety non-tumor necrosis factor (TNF)-α directed vs. TNFα antagonists immunomodulator monotherapy (IMM) (≤5 years). Methods: Through collaborative REACH-IBD (Rising Educators Academics and Clinicians Helping IBD) research initiative, we conducted a retrospective, multi-center cohort study. included from 12 centers (Cohort A) within...