Autism is associated with gastrointestinal dysfunction and gut microbiota dysbiosis, including an overall increase in Clostridium. Modulation of the suggested to improve autistic symptoms. In this study, we explored implementation two different interventions that target a rodent model autism their effects on social behavior: levels fecal Clostridium spp., hippocampal transcript levels. was induced young Sprague Dawley male rats using oral gavage propionic acid (PPA) for three days, while...

Autism spectrum disorders (ASD) consist of a range neurodevelopmental conditions accompanied by dysbiosis gut microbiota. Therefore, number microbiota manipulation strategies were developed to restore their balance. However, comprehensive comparison the various methods on is still lacking. Here, we evaluated effect Bifidobacterium (BF) treatment and fecal transplantation (FT) in propionic acid (PPA) rat model autism using 16S rRNA sequencing. Following PPA treatment, showed depletion...

Background Most studies on emotions in the perinatal period have focused psychopathology, identifying groups of women with distinct symptom trajectories, but research typical, normative changes across is scarce. This study examines typical patterns low-risk, healthy population.

Autism spectrum disorder (ASD) is associated with excitatory-inhibitory imbalance and oxidative stress. GABA, an inhibitory neurotransmitter, related nutritional therapies are promising in restoring these imbalances. GABAergic deficits glutamate excitotoxicity two essential signaling pathways that could be addressed to treat autism, thus medications targeting critical for treating behavioral symptoms. In a rat model of autism produced by propionic acid (PPA), this study assessed the effects...

Progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta is primary cause for motor symptoms observed Parkinson's disease (PD). Mutations leucine-rich repeat kinase 2 (LRRK2) are most commonly linked contributor to familial PD. LRRK2 suggested be involved a wide variety cellular processes, but deciphering its role pathogenesis PD has been difficult. Modelling rodents persistent challenge field. However, fruit fly exploited recapitulate gene related cell loss....

Maternal stress has a profound impact on the long-term behavioral phenotype of offspring, including responses to stressful and social situations. In this study, we examined effects maternal exposure predator odor, an ethologically relevant psychogenic stressor, stress-induced behaviors in both semi-naturalistic laboratory-based Adult C57BL/6 mice offspring dams exposed odor during last half pregnancy showed increased anti-predatory behavior, more cautious foraging behavior and, elevated plus...

Collaboration between physicians and nurses is essential to healthcare delivery associated with high-quality patient care, greater satisfaction, better health outcomes. Hence, it imperative that doctors have a particular set of interprofessional collaboration skills. This descriptive cross-sectional study assessed how medical students in the pre-clinical clinical years perceived attitudes toward hospital setting. The Jefferson Scale Attitude Physician–nurse (JSAPNC) was reverse-translated...

A cardinal feature of the reaction to stress is promotion energy mobilization, enabling appropriate behavioural responses. Predator odours are naturalistic and ecologically relevant stressors present over evolutionary timescales. In this study, we asked whether maternal predator odour exposure could program long-term mobilization in C57BL/6 mice offspring. To test hypothesis, measured rates oxygen consumption prenatally exposed adulthood while controlling for levels locomotor activity at...

Pregnancy outcomes are influenced by maternal distress but the pathways underlying these effects still unknown. Mitochondria, crucial for stress adaptation and energy production, may link psychosocial to its biological effects, especially during pregnancy when demands significantly increase. This study explores two mitochondrial markers-circulating cell-free DNA (cf-mtDNA) Growth Differentiation Factor-15 (GDF15)-as potential health indicators linking in longitudinal studies from USA Turkey.

Abstract It is proposed that gluten- and casein-rich diets (GRD CRD) can synergistically exacerbate dysbiosis as comorbidity in autism by worsening leaky gut affects the brain through gut–brain axis. In this study, 35 young male rats were divided into 7 groups, Group 1 serves control; 2, clindamycin (CL)-treated; 3, propionic acid (PPA)-induced rodent model of autism. These three groups fed standard diet until end experiment. Groups 4–7 are treated similarly with CL PPA, then on CRD or GRD...

Abstract Rodent pups emit ultrasonic vocalizations (USVs) to solicit maternal behavior, promoting their survival. Conversely, behaviors affect the expression of pup USVs. We previously demonstrated that a diet high in saturated fat (HFD) alters behavior and is associated with early maturation stress physiology. Here, we assessed developmental profiles USVs using quantitative qualitative measures on postnatal days (PND)7 13. Quantitative included call counts, duration, frequency, while...

Asthma is a common chronic inflammatory condition with increasing global prevalence. There some evidence highlighting the effect of asthma on brain functioning. In Saudi Arabia, limited studies have examined relationship between and mental health, including cognition mood disorders in older adults particular. this study, we examine association health outcomes middle-aged elderly individuals Riyadh, Arabia. cross-sectional 243 subjects were recruited from outpatient clinics 2020-2021...

Abstract Adverse maternal diets high in saturated fats are associated with impaired neurodevelopment and epigenetic modifications offspring. Maternal milk, the primary source of early life nutrition mammals, contains lactation-specific microRNAs (miRNAs). Lactation-specific miRNAs have been found various offspring tissues life, including brain. We examined effects fat diet (mHFD) on that inhibit DNA methyltransferases (DNMTs), enzymes catalyze methylation modifications, amygdala female...

Predation is a key organizing force in ecosystems. The threat of predation may act to programme the endocrine hypothalamic–pituitary–adrenal axis during development prepare offspring for environment they are likely encounter. Such effects typically investigated through measurement corticosteroids (Cort). Corticosteroid-binding globulin (CBG) plays role regulating bioavailability Cort, with only free unbound Cort being biologically active. We prenatal predator odour exposure (POE) mice on CBG...