A5079740849- Genetics and Neurodevelopmental Disorders
- Parathyroid Disorders and Treatments
- Genomics and Rare Diseases
- Genetic Syndromes and Imprinting
- Thyroid and Parathyroid Surgery
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Immunodeficiency and Autoimmune Disorders
- Genomic variations and chromosomal abnormalities
- Medical Imaging and Pathology Studies
- Platelet Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- Epilepsy research and treatment
- Genetic Associations and Epidemiology
- Cellular transport and secretion
- Electrospun Nanofibers in Biomedical Applications
- RNA regulation and disease
- Tissue Engineering and Regenerative Medicine
- Ion channel regulation and function
- RNA modifications and cancer
- Cardiac electrophysiology and arrhythmias
- CRISPR and Genetic Engineering
- Anatomy and Medical Technology
Istanbul University-Cerrahpaşa
2022-2025
Istanbul University
2014-2025
Institute of Neurological Sciences
2023-2025
Bezmiâlem Vakıf Üniversitesi
2017-2024
Neuroscience Institute
2023
Adli Tıp Kurumu
2020
Universidad Nacional de Colombia
2020
Cairo University
2020
Jubail Industrial College
2020
King Fahd University of Petroleum and Minerals
2020
Objective The limited predictive effect of genotype on familial Mediterranean fever (FMF) phenotype suggests that epigenetic factors and alternative mechanisms may cause IL-1β release could contribute to phenotypic heterogeneity. objective this study was examine the role levels miR-21-5p, cathepsin B pyrin levels, which were identified as potential causing through use bioinformatics tools, in pathogenesis FMF their relationship with disease severity. Materials methods 50 paediatric patients...
Introduction Diagnosis, treatment and management of rare diseases (RD) pose unique challenges due to their complex nature, significantly impacting the daily experiences researchers healthcare professionals working in this field. Despite increasing awareness progress field RD worldwide recent years, a significant gap remains our understanding specific barriers that these face work with RD. This study provides detailed survey analysis sheds light on diagnosing, treating, managing conducting...
ABSTRACT siRNA‐loaded nanoparticles open new perspectives for cancer treatment. MAPK6 is upregulated in breast and involved cell growth, differentiation cycle regulation. Herein, we aimed to investigate the anticancer effects of knockdown by using PLGA (siMAPK6‐PLGA‐NPs) MCF‐7 cells. After synthesis characterisation nanoparticles, treatment concentrations were determined with cytotoxicity assay. Subsequently, siMAPK6‐PLGA‐NPs evaluated vitro assays. have been suppress expression efficiently....
Abstract Background Permanent hypoparathyroidism is a serious problem and requires medications indefinitely. Parathyroid allotransplantation ( PA ) with short‐term immunosuppression definitive choice but long‐term results are not clear. Method We performed from two donors to recipients. Both recipients were 39‐year‐old females. Donors 32‐year‐old female 36‐year‐old male, who both have chronic kidney disease. Routine tests, viral markers, cross‐matches analyzed individually. The parathyroid...
Abstract Permanent hypoparathyroidism is a severe clinical condition accompanied by low parathyroid hormone level. Conventional treatment requires lifelong medication, and daily drug usage has some side effects. To avoid this circumstance, transplantation an alternative curative option. Microencapsulation may be used as approach particularly to evade immune response. In order define of permanent hypoparathyroidism, 37‐year‐old female recipient who was evaluated for 3 years. Routine tests,...
Rare disease patients constitute a significant part of the healthcare system all countries. However, information on experiences during processes and daily life rare is still limited. So far, there small number studies conducted in Türkiye, they mainly cover specific issues like education or anxiety. Here we present comprehensive survey analysis among their families within scope Istanbul Solution Platform for Undiagnosed Diseases-ISTisNA project. A total 498 individuals responded to survey,...
Background/aim: MicroRNAs (miRNAs) are known up-to-date candidate biomarkers for several diseases. In addition, obtaining miRNA from different body fluids such as serum, plasma, saliva, and urine is relatively easy to handle. Herein we aimed detect miRNAs early stage prostate cancer (PC). For this purpose, used serum samples any significant differences in profiles between patients healthy controls. Materials methods: Total ribonucleic acid (RNA) were isolated eight untreated PC patients,...
The aim of this study is to evaluate the utility an artificial neural network (ANN) model in diagnosing idiopathic generalized epilepsy (IGE) and compare results diagnostic constructed by combining expression levels miR‐146a, miR‐155, miR‐132 genes using ANN, random forest (RF), discriminant analysis (DA). qRT‐PCR employed determine three miRNA genes. Forty‐six IGE patients 51 healthy controls were included study. Three genetic biomarkers assess discriminative power disease, they combined...
Permanent hypoparathyroidism is an endocrine disease that mostly associated with the disruption of parathyroid glands during surgery. Allotransplantation most promising approach for treatment particularly its cost-effective and exact curative potential. Herein our aim was to evaluate human leukocyte antigen (HLA)-A allele matching effect on clinical improvement graft survival after transplantation. We performed transplantation between ABO/Rh compatible recipient unrelated donor who has...
Cold ischemia protects organs and tissues by slowing their metabolism, but it also causes ischemic injury. Minimizing cold has been an important goal in parathyroid auto- allotransplantation, as well the transplantation of other major organs. Parathyroid glands are responsible for calcium homeostasis releasing parathormone (PTH) into blood circulation. Functionality a new transport solution (NPTS) effects on cell viability, PTH secretion, calcium-sensing receptor (CaSR) levels during were...