A5016632208- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Brain Metastases and Treatment
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Cells and Metastasis
- Neurosurgical Procedures and Complications
- Management of metastatic bone disease
- Cerebrospinal fluid and hydrocephalus
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Medical Imaging Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Cerebral Venous Sinus Thrombosis
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Natural product bioactivities and synthesis
- Cancer-related cognitive impairment studies
Toho University
2015-2024
Toho University Ohashi Medical Center
2015-2024
Sakushin Gakuin University
2024
Nippon Medical School Hospital
2016
Juntendo University
2016
Neurology, Inc
2016
National Kyushu Medical Center
2016
Clinical Research Institute
2016
Intensive Care Society
2016
Tokyo Metropolitan Children's Medical Center
2016
The NOTCH pathway regulates neural stem cells and glioma initiating (GICs). However, blocking activity with γ-secretase inhibitors (GSIs) fails to alter the growth of GICs, as GSIs seem be active in only a fraction GICs lines constitutive activity. Here we report loss PTEN function critical event leading resistance inhibition, which causes transfer oncogene addiction from PI3K pathway. Drug cytotoxicity testing eight showed differential response GSI, were thus stratified into two groups:...
we investigated the clinical efficacy of intra-arterial administration fasudil hydrochloride for cerebral vasospasm.we reviewed 90 cases treated with between August 1998 and April 2009 vasospasm.angiographic improvement vasospasm was noted in all procedures. Eight had ischemic lesion on CT at discharge Group A, which included 39 patients who presented angiographic symptomatic vasospasm. However, 4 (50%) these eight were recovered a condition GR. No showed B, 51 without symptoms. Two (3.3%)...
When internal carotid artery stenosis is accompanied by ocular ischemic syndrome, intervention recommended to prevent irreversible visual loss. In this study, we used laser speckle flowgraphy measure the microcirculation in optic nerve head before and after stenting (CAS) of 40 advanced lesions from 37 patients. The aim was investigate relationship between direction ophthalmic blood flow obtained angiography. We found that there a significant increase CAS (<mml:math...
Two patients were treated for intracranial infections involving methicillin-resistant Staphylococcus aureus (MRSA). A 30-year-old woman was admitted to our hospital intracerebral hemorrhage related arteriovenous malformation. After decompressive craniectomy, the patient developed an epidural abscess. MRSA isolated from pus culture. The infection did not improve after intravenous vancomycin (VCM) administration 15 days. However, of linezolid (LZD) 14 days, had improved, and white blood cell...
The cerebral circulatory dynamics were evaluated before and after intra-arterial administration of fasudil hydrochloride in 20 patients with angiographic vasospasm subarachnoid hemorrhage (SAH). region interest time-density curves obtained compared the proximal portion middle artery early arterial phase, distal late transverse sinus venous phase. In time to peak half-peak significantly reduced. phase was These results suggest that induced dilation arteries, improved microcirculation. present...
The Cancer Genome Atlas (TCGA) project described a robust gene expression-based molecular classification of glioblastoma (GBM), but the functional and biological significance subclasses has not been determined. present comprehensive analysis 25 glioma-initiating cell (GIC) lines classifies GIC into four subtypes (classical, mesenchymal, proneural, neural) that are closely related to TCGA GBM display distinct lineage characteristics differentiation behavior recapitulate neural development....
As methods of cancer diagnosis and treatment improve, interest in metastatic brain tumors continues to increase. In the present study, we attempted characterize genetically dynamic changes occurring during metastasis formation by DNA microarray, compare these findings with histological observations. Lewis lung carcinoma cells were injected into C57BL/6Ncrj mice carotid arteries. The sacrificed at days 1–9 after injection. We performed observation genome‐wide expression profiling using a...
A 14-year-old was girl admitted to our hospital with a subcutaneous mass of the occipital head. The had grown for 6 years, after she sustained head injury at age 6, and located directly under previous wound. Skull X-ray Photograph (xp), computed tomography (CT), magnetic resonance imaging (MRI) showed bony defect cystic changes in skull corresponding mass. Bone scintigraphy revealed partial accumulation. patient underwent total removal mass, diagnosis from pathological findings cyst wall...
A 54-year-old woman presented to our hospital with progressive motor weakness of the right arm. She had a medical history systemic lupus erythematosus (SLE) and hypothyroidism. Magnetic resonance imaging indicated watershed infarction left hemisphere. Cervical echogram severe stenosis internal carotid artery (ICA) without wall thickening. Cerebral angiography ICA occlusion, development unilateral moyamoya vessels, leptomeningeal anastomosis. Encephaloduroarteriosynangiosis (EDAS) was...
Abstract Glioblastoma, the most common adult glioma, is associated with a dismal prognosis. Treatment bevacizumab has not significantly prolonged overall patient survival times. Glioblastoma resistance to angiogenesis inhibitors attributed multiple interacting mechanisms. We have thus embarked on comprehensive effort detecting expression signatures that are response therapy and these may allow prospective selection of patients high likelihood responding therapy. Notch signaling pathway an...
Abstract Tumor angiogenesis occurs in the setting of a defective vasculature, which is associated with increased vascular permeability and enhanced tumor permeability. Bevacizumab used to treat malignant glioma was found reduce microvascular density prune abnormal microvessels. Using electron microscopic observation two autopsy cases, we investigated effects blood vessel normalization glioblastomas treated bevacizumab. Notch-1 SMA immunostaining were compare initial surgical specimens...
Prolactin-secreting pituitary neuroendocrine tumors (PitNETs) are more common in women. Male patients may also have few symptoms and macroadenomas extending outside the sella turcica. This study aimed to report results of cabergoline treatment male with prolactin-secreting PitNET. The included nine aged 26-65 years (median, 46 years) diagnosed PitNETs. age at onset, prolactin values, tumor size, symptoms, were assessed. mean value initial presentation was 2734.6 ng/mL, maximum diameter 40.4...
Tumor-treating fields (TTFields) is an established treatment modality for glioblastoma. False progression to chemoradiation a known problem in patients with glioblastoma multiforme (GBM), most cases occurring within three months of radiation therapy. In this report, we present two delayed pseudoprogression caused by TTFields. Two GBM who received TTFields showed signs radiographic six after the completion Patient 1 was 37-year-old female right temporal lobe. 2 70-year-old male left Both...
This study compared magnetic resonance imaging (MRI) findings of postmortem brain specimens with neuropathological to evaluate the value MRI. Postmortem MRI was performed on five formalin-fixed whole brains malignant tumors. T2-weighted images detected all abnormalities as high-signal regions but also showed histological tumor invasion in areas without edema. Tumor lesions high necrosis and edema signal intensity images; three cases, lesion enlargement final prenatal Disease progression...
A woman in her 20s fell down during cheerleading practice and she was referred to our neurosurgical outpatient clinic the next day due persistent headache, neck pain, dizziness. Neurological examination showed left upper limb paresis. MRI revealed a remarkably dilated flow void along dural sac on side between C2 C3 levels. Cerebral angiography confirmed shunt from vertebral artery vein. Preoperative ultrasonography that diameter of markedly 10mm, blood volume cervical vertebrae 1,873ml/min....
Abstract INTRODUCTION Diffusion Weighted Whole Body Imaging with background body signal Suppression (DWIBS) is an imaging technique that encompasses comprehensive of the entire through diffusion-weighted (DWI). In recent years, it has been increasingly utilized for investigating etiology fever or primary cancer. Here we present two cases DWIBS searching cancer in patient intracranial metastasis. CASE PRESENTATION Case1: A 60-year-old man presented headache and diplopia was admitted to our...
Abstract INTRODUCTION In meningioma surgery, the removal of tumor and tumor-attached dura mater is essential. Due to its high affinity, absorbable artificial used for reconstruction dural defects. this study, we report a pathological examination dural-like tissue in case that recurred at same site after use during initial surgery. METHOD We investigated two cases which was resection, subsequently, recurrent lesion identified reconstruction. examined MRI images surgical findings time...
Abstract INTRODUCTION Aroma essential oils apply to cancer therapy because of their immune-enhancing and sedative effects, ability reduce the side effects chemotherapy. Recently, aroma have also been reported anti-tumor effects. We investigate aromatic compounds contained in as a novel treatment for glioblastoma. In this study, we analyzed antitumor effect lemongrass oil investigated its methods RESULTS Human glioblastoma cells (U87, T98G) mouse brain tumor (RSV-M) were used study. Tumor...
Abstract INTRODUCTION DWIBS is an abbreviation for Diffusion Weighted Whole Imaging with Background body signal Suppression. It imaging method that uses MRI diffusion-weighted (DWI) to image the entire in multiple locations and then integrates them form a wide-area image. In recent years, has been used search heat sources of unidentified fever distant metastasis cancer. this report, we describe two cases which was useful primary tumor patients brain metastases. CASE PRESENTATION Case 1: Male...
Abstract BACKGROUND In glioblastoma, the only chemotherapy with a clear prognostic effect is temozolomide. Research and development of novel therapies to overcome glioblastoma resistance treatment ongoing. We have been studying antitumor aromatherapy using aromatic compounds in essential oils as new for glioblastoma. this study, we focus on citral, main component lemongrass oil, report that oil shows anti-tumor effects glioma cells mouse brain tumor models. METHODS used human (U251, T98G)...