A5109745734- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Neuroblastoma Research and Treatments
- AI in cancer detection
- Silicon Nanostructures and Photoluminescence
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Gene expression and cancer classification
- Cancer Immunotherapy and Biomarkers
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced Breast Cancer Therapies
- Palliative Care and End-of-Life Issues
- Silicon Effects in Agriculture
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Bioinformatics and Genomic Networks
- Neutropenia and Cancer Infections
- Cardiovascular Health and Disease Prevention
- Childhood Cancer Survivors' Quality of Life
- Cancer survivorship and care
George Washington University
2025
Qingdao University of Technology
2025
Peking University
2015-2023
Peking University Cancer Hospital
2015-2023
North China University of Science and Technology
2016
Tangshan People's Hospital
2016
Background and Objective: With the rapid development of accumulation large-scale multiomics data sets, integrating various omics to provide a thorough study from multiple perspectives can significantly stronger support for precise treatment diseases. However, due complexity data, issues feature redundancy noise often do not receive sufficient attention when processing high-dimensional data. Moreover, simple concatenation strategies may overlook correlations between different failing...
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) are crucial in regulating cell cycle progression cancer development. Targeting CDK4/6 has shown considerable promise treating various cancers, including breast cancer. Despite significant therapeutic efficacy, resistance to inhibitors (CDK4/6i), such as palbociclib, remains a substantial hurdle clinical practice. Using co-culture system, cytokine array, quantitative high-throughput combinatorial screening (qHTCS), we discovered mechanism by...
Background and purpose Routine screening for asymptomatic cranial‐carotid stenosis ( ACCS ) is controversial recommendation in clinical practice vague. The ankle−brachial index ABI reported as a predictor cardiovascular disease. However, there scarcity of data about the association between abnormal . A population‐based cross‐sectional study was conducted to explore relationship Methods sample 5440 Chinese adults aged 40–94 years old recruited from 2010 2011. measured using portable Doppler...
Interleukin 2 inducible T cell kinase (ITK) is involved in both receptor (TCR) signaling and differentiation of helper cells. ITK-/- mice have defects Th2 resulting skewing toward Th1 cells that secrete IFN-γ. CPI-818 a selective covalent inhibitor ITK (Kd 2.5 nM). Its activity was assessed murine lymphoma EL4 model demonstrated anti-tumor by increasing infiltration normal CD8+ the tumors. In vivo CD8 CD4 depletion reduced activity, indicating tumor microenvironment infiltrating are...
Background: Gastric cancer (GC) is the third leading cause of deaths in world. It highly heterogeneous. Many molecular therapies for GC have entered clinical trials but, apart from trastuzumab, apatinib and ramucirumab, all failed. One important reason that insufficient attention paid to underlying subtypes characteristics GC, especially diffuse-type gastric (DGC) according Lauren classification with worst outcomes. Aim: Here we firstly investigated formalin-fixed paraffin-embedded (FFPE)...