A5013406801- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Global Health and Surgery
- Global Maternal and Child Health
- Health Systems, Economic Evaluations, Quality of Life
- HIV/AIDS Impact and Responses
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Outbreaks Research
- Diagnosis and treatment of tuberculosis
- Health and Medical Research Impacts
- Antibiotic Use and Resistance
- Global Public Health Policies and Epidemiology
- Mycobacterium research and diagnosis
- Pregnancy and preeclampsia studies
- Malaria Research and Control
- Adolescent Sexual and Reproductive Health
- scientometrics and bibliometrics research
- Biosimilars and Bioanalytical Methods
- HIV/AIDS Research and Interventions
- Vaccine Coverage and Hesitancy
- Poverty, Education, and Child Welfare
- Global Health and Epidemiology
- Clinical Laboratory Practices and Quality Control
- Patient Dignity and Privacy
- Pharmaceutical Economics and Policy
Stellenbosch University
2022-2025
South African Medical Research Council
2014-2025
European & Developing Countries Clinical Trials Partnership
2007-2024
Kamuzu Central Hospital
2023
Kamuzu University of Health Sciences
2023
Nasarawa State University
2009
Research for Equity And Community Health Trust
1998-2007
World Health Organization - Malawi
2004-2005
World Health Organization - Pakistan
2004
Ministry of Health
2000-2002
Malaria infections during pregnancy can lead to the delivery of low-birth-weight infants. In this study, cytokine mRNA was measured in placentas from 23 malaria-infected and 21 uninfected primigravid women who had delivered Mangochi, Malawi, a region with high rate transmission falciparum malaria. Significantly increased expression interleukin (IL)—1β, IL-8, tumor necrosis factor (TNF)—α decreased IL-6 transforming growth factor-β1 were found compared placentas. TNF-α IL-8 produced by...
Background Over the last 30 years, South Africa has experienced four ‘colliding epidemics’ of HIV and tuberculosis, chronic illness mental health, injury violence, maternal, neonatal, child mortality, which have had substantial effects on health well-being. Using data from 2019 Global Burden Diseases, Injuries Risk Factors Study (GBD 2019), we evaluated national provincial trends progress towards important Sustainable Development Goal targets 1990 to 2019. Methods We analysed GBD estimates...
Tuberculosis (TB) remains a leading cause of death globally and is estimated to have caused 1.3 million deaths worldwide in 2022. Approximately one quarter the world's population are infected with Mycobacterium tuberculosis, whom up 10% will progress developing active TB disease. Achieving WHO End Strategy targets 95% reduction mortality 90% incidence worldwide, by 2035, daunting task. The continuing spread multi-drug resistant adds another obstacle achieving global control. Larger funding...
In sub-Saharan Africa, malaria infection in pregnancy contributes to low birth weight through intrauterine growth retardation (IUGR) and preterm delivery (PTD). It was hypothesized that malaria-associated PTD IUGR have differing etiologies due timing of infection. a prospective cohort primigravid women enrolled at the antenatal clinic Mangochi District Hospital Malawi, associations were investigated between or parasitemias PTD. Among 178 singleton deliveries, 35% infants had IUGR. Cord blood...
Dr Thato Mosidi never expected to be diagnosed with tuberculosis (TB), despite widely prevalent exposure and very limited infection control measures. The life-threatening diagnosis of primary extensively drug-resistant TB (XDR-TB) came as an even greater shock. inconvenient truth is that, rather than being protected, thousands her healthcare colleagues are at increased risk especially TB. In this viewpoint paper we debunk the held false belief that workers somehow immune disease (TB-proof)...
Tuberculosis (TB) today remains a global emergency affecting 9.0 million people globally. The African Region bears the highest TB/HIV burden and over 50% of TB cases in SSA are co-infected with HIV. An estimated 1.5 died from globally 2013. A large majority 360,000 HIV-positive who were sub-Saharan Africa. Research development is an important pillar WHO post-2015 strategy. Advances diagnostics, drugs, host-directed therapies, vaccines will require evaluation under field conditions through...
The recognition and progression of an academic or research career is hinged on the number quality publications in high-impact journals. Open access publication, especially journals, confers a significant citation (ie, progression) advantage.1 However, there increasing demand for publication fees article processing charges (APCs), by open Where does this leave African researchers who earn too little (personal income grants) to publish such top-tier journals? Already, Africa contributes much...
Increased taxation on alcohol and tobacco is among the cost-effective measures used to deal with burden of noncommunicable diseases (NCDs) globally. Despite adopting such efforts, impacts are yet be fully understood. The study's objective find empirical evidence regarding changes in NCD mortality rate associated tax rates alcohol. study adopted System Generalized Method Moments (SGMM) explore relationship between levels taxes rates. SGMM allowed inclusion dependent variable as an explanatory...
The objective was to guide key stakeholders on future directions of external funding international postgraduate training (Master's and PhD) health research students at institutions in sub-Saharan Africa by mapping the numbers characteristics students, location institutions, sources support. A cross-sectional survey eligible organizations programmes conducted 2017. Information gathered from funders' websites or through assistance institutional contacts. information requested included number...
Health challenges and health systems set-ups differ, warranting contextualised healthcare interventions to move towards universal coverage. As such, there is emphasis on generation of contextualized evidence solve local challenges. However, weak research capacity inadequate resources remain an impendiment quality in the African region. WHO Region (WHO AFR) facilitated adoption a regional strategy for strengthening national (NHRS) 2015. We assessed progress NHRS among 47 member states AFR....
Global research collaboration, through partnerships and networks, is an effective way to deliver highly impactful sustainable that collectively owned promoted for the global good. Many models exist North-South collaborations are built on trust balanced benefits. The European & Developing Countries Clinical Trials Partnership (EDCTP) model emphasises capacity development in clinical trials product-focused implementation research. To ensure effectiveness sustainability, requires a long-term...
Although sub-Saharan Africa has the highest rates of tuberculosis (TB) and human immunodeficiency virus (HIV) infection in world, TB amongst its health care workers (HCWs) are poorly documented. We therefore conducted a country-wide investigation. All district/government mission hospitals Malawi that diagnose for patients were visited order to obtain information on hospital-based HCWs their incidence 1996. Hospital case loads, notification numbers national population estimates 1996 obtained,...
National tuberculosis control programmes (NTPs) in sub-Saharan Africa do not routinely record or report treatment outcome data on smear-negative pulmonary (PTB) patients. Twelve-month patients with PTB registered all district and mission hospitals Malawi during the year 1995 was collected, compared 8-month smear-positive same period. Of 4240 PTB, 35% completed treatment, 25% died, 9% defaulted 7% were transferred to another no results available. In 24% of cards lost unknown. These...