A5101606889- Food Allergy and Anaphylaxis Research
- Cancer-related molecular mechanisms research
- Allergic Rhinitis and Sensitization
- Fungal Biology and Applications
- Chemokine receptors and signaling
- Ear and Head Tumors
- Vestibular and auditory disorders
- Synthesis of heterocyclic compounds
- Genomics, phytochemicals, and oxidative stress
- Sarcoma Diagnosis and Treatment
- Air Quality and Health Impacts
- Cancer, Stress, Anesthesia, and Immune Response
- Galectins and Cancer Biology
- Tea Polyphenols and Effects
- Mesenchymal stem cell research
- Microbial Natural Products and Biosynthesis
- RNA modifications and cancer
- Retinal Diseases and Treatments
- Neuropeptides and Animal Physiology
- Circular RNAs in diseases
- Bone Tumor Diagnosis and Treatments
- Biosensors and Analytical Detection
- Cholinesterase and Neurodegenerative Diseases
- Protein Hydrolysis and Bioactive Peptides
- Tissue Engineering and Regenerative Medicine
Shenzhen University
2015-2024
Tianjin Medical University
2022
Tianjin Medical University Eye Hospital
2022
Shenzhen University Health Science Center
2017-2021
Qilu Hospital of Shandong University
2017
SUNY Upstate Medical University
2006
The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study expression and regulation, function clinical implication human non-small lung (NSCLC).One hundred six patients with histologically-confirmed NSCLC who underwent surgery were recruited for the study. Tumor samples lines used examine its related molecules. Various functions performed. In vivo mouse tumor xenograft was confirm vitro results.NSCLC high level had a significant decrease overall survival...
Chronic overconsumption of lipids followed by their excessive accumulation in the heart leads to cardiomyopathy. The cause lipid-induced cardiomyopathy involves a pivotal role for proton-pump vacuolar-type H+-ATPase (v-ATPase), which acidifies endosomes, and lipid-transporter CD36, is stored acidified endosomes. During lipid overexposure, an increased influx into cardiomyocytes sensed v-ATPase, then disassembles, causing endosomal de-acidification expulsion CD36 from endosomes toward...
Obesity/overweight and lipid metabolism disorders have become increased risk factors for lung cancer. Fatty acid translocase CD36 promotes cellular uptake of fatty acids. Whether how facilitates adenocarcinoma (LUAD) growth in high-fat environment is unknown. Here, we demonstrated that palmitic (PA) or diet (HFD) promoted LUAD cell proliferation metastasis a CD36-dependent manner. Mechanistically, translocated from cytoplasm to membrane interacted with Src kinase upon PA stimulation human...
Epidemiological observations have demonstrated that ambient fine particulate matter with dp < 2.5 μm (PM2.5) as the major factor responsible for increasing incidence of lung cancer in never-smokers. However, there are very limited experimental data to support association PM2.5 carcinogenesis and compare smoking carcinogens.To study whether can contribute tumorigenesis a way similar carcinogen 4-methylnitrosamino-l-3-pyridyl-butanone (NNK) via 15-lipoxygenases (15-LOXs) reduction, normal...
Abstract Background Translationally controlled tumor protein (TCTP) is linked to lung cancer. However, upon cancer carcinogens stimulation, there were no reports on the relationship between TCTP and cell carcinogenic epithelial–mesenchymal transition (EMT). This study was designed investigate molecular mechanism of regulation expression its role in carcinogens-induced EMT. Methods To [particulate matter 2.5 (PM ) or 4-methylnitrosamino-l-3-pyridyl-butanone (NNK)]-induced EMT, PM /NNK-treated...
Although brachytherapy has been used in the management of soft tissue sarcoma for decades, there is little published data regarding dose and toxicity. We performed an interim analysis our high dose-rate experience to establish dosing guidelines.We analyzed first 12 patients treated with as tumor bed boost (in conjunction beam therapy), seeking association between treatment factors wound-healing complications. In process analysis, we devised a dosimetric method retrospectively quantify...
This study analyzed the effect of lipid peroxidation using 2,2′-azobis(2-amidinopropane)dihydrochloride (AAPH) and acrolein on in vitro vivo allergenicity α-lactalbumin (α-La). The structure oxidized α-La was evaluated by sodium dodecyl sulfate polyacrylamide gel electrophoresis, fluorescence spectroscopy, circular dichroism, whereas changes allergenic properties were evaluated. Lipid induced to structural that might destroy and/or mask epitopes. In comparison native α-La, oxidation...
Eleven new cyclohexane-type meroterpenoids ( 1 , 3 – 5 7 8 11 15 ) and four known similar 2 6 9 10 were isolated from Ganoderma cochlear. Their structures absolute configurations at stereogenic centers elucidated by using HRESIMS, NMR spectroscopy computational methods. In addition, the structure of meroterpenoid, cochlearol G ), was revised, determined. All evaluated for their activities against renal fibrosis triple negative breast cancer, insulin resistance. The results study showed that...
From the dried fruiting bodies of Ganoderma lucidum, 2 new unsaturated lactones, dayaolingzhilactones A and B (1 2), 1 meroterpenoid, dayaolingzhiol H (3), together with 10 known compounds (4-13), were isolated. Their chemical structures identified by using spectroscopic data calculated specific rotation. The inhibitory activities toward acetylcholinesterase (AchE) assessed in vitro tacrine as positive control. Both them exhibited moderate AchE at concentration 50 μM.
The patient was a 48-year-old male with previous history of diabetes mellitus and hypertension. had persistent bleeding after vitrectomy the left eye, examined for abnormal coagulation factor Ⅷ combined Ⅻ. This case suggests that we need effective control blood glucose pressure in patients undergoing clinical work, adequate examination function. Patients deficiency should be treated plasma transfusion to supplement factors before performing necessary surgical treatment prevent severe...