A5052012678- Radiation Therapy and Dosimetry
- Radiation Effects in Electronics
- Particle Detector Development and Performance
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Photocathodes and Microchannel Plates
- Lung Cancer Treatments and Mutations
- Dark Matter and Cosmic Phenomena
- Ferroptosis and cancer prognosis
- Bioinformatics and Genomic Networks
- Nuclear reactor physics and engineering
- Cancer Genomics and Diagnostics
- Atomic and Subatomic Physics Research
- Cancer Research and Treatments
- Soft tissue tumor case studies
- Cancer-related molecular mechanisms research
- Solid State Laser Technologies
- Particle physics theoretical and experimental studies
- Photorefractive and Nonlinear Optics
- Molecular Biology Techniques and Applications
- Biomedical Text Mining and Ontologies
- Lung Cancer Diagnosis and Treatment
- Academic Publishing and Open Access
- Uterine Myomas and Treatments
- Sarcoma Diagnosis and Treatment
FIT Consulting (Italy)
2022-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Torino
2017-2022
University of Turin
2017-2022
Massachusetts General Hospital
2022
Harvard University
2022
Istituto Nazionale di Fisica Nucleare
2017-2019
Few attempts have been made to include the oxygen enhancement ratio (OER) in treatment planning for ion beam therapy, and systematic studies evaluate impact of hypoxia with different species are sorely needed. The radiobiological models used quantify OER such mainly based on dose-averaged LET estimates, do not explicitly distinguish between fractionation schemes. In this study, a new type modelling, microdosimetric kinetic model, taking into account specificity ions, spectra, tissues...
Advanced ion beam therapeutic techniques, such as hypofractionation, respiratory gating, or laser-based pulsed beams, have dose rate time structures which are substantially different from those found in conventional approaches. The biological impact of the structure is mediated through β parameter linear quadratic (LQ) model. aim this study was to assess changes value on treatment outcomes, also accounting for noninstantaneous intrafraction delivery fractionation and comparing effects using...
Background: The new paradigm of precision medicine brought an increasing interest in survival prediction based on the integration multi-omics and multi-sources data. Several models have been developed to address this task, but their performances are widely variable depending specific disease often poor noisy datasets, such as case non-small cell lung cancer (NSCLC). Objective: aim work is introduce a novel computational approach, named multi-omic twolayer SVM (mtSVM), exploit it get...
To fully exploit the physics potentials of particle therapy in delivering dose with high accuracy and selectivity, charged needs further improvement. this scope, a multidisciplinary project (MoVeIT) Italian National Institute for Nuclear Physics (INFN) aims at translating research into clinical outcome. New models treatment planning system are being developed validated, using dedicated devices beam characterization monitoring radiobiological irradiations. Innovative silicon detectors...
Abstract Recent advances in machine learning research, combined with the reduced sequencing costs enabled by modern next-generation sequencing, paved way to implementation of precision medicine through routine multi-omics molecular profiling tumours. Thus, there is an emerging need reliable models exploiting such data retrieve clinically useful information. Here, we introduce original consensus clustering approach, overcoming intrinsic instability common methods based on data. This approach...
Abstract Beam monitoring in particle therapy is a critical task that, because of the high flux and time structure beam, can be challenging for instrumentation. Recent developments thin silicon detectors with moderate internal gain, optimized timing applications (Ultra Fast Silicon Detectors, UFSD), offer favourable technological option to conventional ionization chambers. Thanks their fast collection good signal-to-noise ratio, properly segmented sensors allow discriminating counting single...
One major rationale for the application of heavy ion beams in tumour therapy is their increased relative biological effectiveness (RBE). The complex dependencies RBE on dose, endpoint, position field etc require use biophysical models treatment planning and clinical analysis. This study aims to introduce a new software, named 'Survival', facilitate radiobiological computations needed therapy. simulation toolkit was written C++ it developed with modular architecture order easily incorporate...
Recently, there has been a growing interest in bioinformatics toward the adoption of increasingly complex machine learning models for analysis next-generation sequencing data with goal disease subtyping (i.e., patient stratification based on molecular features) or risk-based classification specific endpoints, such as survival. With gene-expression data, common approach consists characterising emerging groups by exploiting differential expression analysis, which selects relevant gene sets...
Abstract Introduction: Non-small cell lung cancer (NSCLC) is a highly heterogenous disease with the largest number of cancer-related mortality worldwide, one reasons for this complex and diverse tumor microenvironment (TME) comprising numerous types. Several studies have already highlighted importance TME in dictating progression steps response to therapies; however, transcriptome-based molecular subtyping patients adenocarcinomas (LUADs) squamous carcinomas (LUSCs) can further determine...
The Single Event Upset rate of a 64 channels integrated circuit, designed in CMOS $0.35 μm technology, has been measured and analyzed at the SIRAD facility Italian National Institute for Nuclear Physics (INFN). chip, named TERA09, is current to frequency converter readout monitor chambers particle therapy. In this field, accelerator development moving toward compact solutions providing high-intensity pulsed-beams. TERA09 chip capable operate wide input range, from few nA hundreds μA, with...
Objective.In intensity modulated particle therapy (IMPT), the adoption of spatially and temporally heterogeneous dose distributions allows to decouple fractionation scheme from patient anatomy, so that an hypofractionated schedule can be selectively created inside tumour, while simultaneously exploiting effect in healthy tissues. In this paper, authors show reproducibility method on a set prostate patients, quantifying dependencies achievable benefit with respect conventional schemes...
The use of ions in radiation therapy aims at improving the selectivity irradiation thanks to a favourable depth-dose profile and, case heavy ions, their enhanced radiobiological effect. treatment modality employing actively scanned pencil beams provides highly conformal dose distributions but is sensitive uncertainties calculation, delivery and measurement. During treatment, beam has be controlled real time monitored with high accuracy, including any effect due patient positioning motion....
The medical physics group of the Turin section National Institute Nuclear Physics, on behalf MoVeIT collaboration, is working for development a new prototype silicon strip detector particle therapy applications. This device, based 50 μm thin sensors with internal gain, aims to detect single beam and count their number up 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> cm xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /s fluxes,...