A5005758533- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Advanced Banach Space Theory
- Chronic Myeloid Leukemia Treatments
- Animal Genetics and Reproduction
- CAR-T cell therapy research
- Influenza Virus Research Studies
- Approximation Theory and Sequence Spaces
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Muscle Physiology and Disorders
- Chronic Lymphocytic Leukemia Research
- Molecular Sensors and Ion Detection
- Renal and related cancers
- Pharmacovigilance and Adverse Drug Reactions
- Neutropenia and Cancer Infections
- Genetics and Neurodevelopmental Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Data-Driven Disease Surveillance
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
University of Oxford
2023-2024
University Hospitals Bristol NHS Foundation Trust
2022-2023
University Hospitals Bristol and Weston NHS Foundation Trust
2022-2023
MRC Weatherall Institute of Molecular Medicine
2023
Bristol Hospital
2022
University of Surrey
2004-2020
Royal Surrey County Hospital
2020
Institute of Cancer Research
2011-2014
John Radcliffe Hospital
2010
Medical Research Council
2010
Assessment of measurable residual disease (MRD) by quantitative reverse transcription polymerase chain reaction is strongly prognostic in patients with NPM1-mutated acute myeloid leukemia (AML) treated intensive chemotherapy; however, there are no data regarding its utility venetoclax-based nonintensive therapy, despite high efficacy this genotype. We analyzed the impact NPM1 MRD an international real-world cohort 76 previously untreated AML who achieved complete remission (CR)/CR incomplete...
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal hierarchical regulatory network set transcription factors expressed in PM that initiates organogenesis. Genetic perturbation this mice resulted muscle defects, revealing robust cross-regulation between its members. We identified Lhx2...
The complex relationship between ontogeny and phylogeny has been the subject of attention controversy since von Baer’s formulations in 19th century. classic concept that embryogenesis progresses from clade general features to species-specific characters often revisited. It become accepted embryos a show maximum morphological similarity at so-called phylotypic period (i.e., during mid-embryogenesis). According hourglass model, body plan conservation would depend on constrained molecular...
Current therapies, including autologous CAR-T immunotherapy, fail to cure half of infants with KMT2A-rearranged acute lymphoblastic leukemia (KMT2Ar-ALL). Here we deploy allogeneic iNKT cells, innately more powerful effectors than T and equip them CD19- and/or CD133-targeting CARs. Compared mono-specific counterparts bi-specific CAR-T, CD19-CD133 CAR-iNKT have potent anti-leukemia activity, they effectively target CAR antigen-low leukemia, eradicate medullary leptomeningeal induce sustained...
The specification of the skeletal muscle lineage during craniofacial development is dependent on activity MYF5 and MYOD, two members myogenic regulatory factor family. In absence or MYOD there not an overt phenotype, whereas in double Myf5;MyoD knockout branchiomeric precursors fail to be specified formed. transcriptional regulation Myf5 controlled by a multitude elements acting at different times anatomical locations, with least five operating branchial arches. By contrast, only enhancers...
The transcriptional regulation of the Mrf4/Myf5 locus depends on a multitude enhancers that, in equilibria with transcription balancing sequences and promoters, regulate expression two genes throughout embryonic development adult. Transcription particular set muscle progenitors can be driven by combined outputs several that are not able to recapitulate entire pattern isolation, or action single enhancer activity which isolation is equivalent within context locus. We identified new element...
Hematopoiesis is a finely orchestrated process, whereby hematopoietic stem cells give rise to all mature blood cells. Crucially, they maintain the ability self-renew and/or differentiate replenish downstream progeny. This process starts at an embryonic stage and continues throughout human lifespan. Blood cancers such as leukemia occur when normal hematopoiesis disrupted, leading uncontrolled proliferation block in differentiation of progenitors particular lineage (myeloid or lymphoid)....
Influenza contributes significantly to the burden of disease worldwide; United Kingdom has a policy vaccination across all ages. vaccinations are known be associated with common minor adverse events interest (AEIs). The European Medicines Agency (EMA) recommends ongoing surveillance AEIs following influenza monitor and detect infrequent but important AEIs.A retrospective cohort study using computerised medical record data from Royal College General Practitioners (RCGP) Research Surveillance...
Infant ALL (iALL) is initiated in utero, most often by rearrangement of the KMT2A gene (KMT2Ar). It carries a very poor prognosis despite lack additional oncogenic driver mutations common childhood ALL. Here, we aimed to identify specific properties human fetal hematopoietic stem/progenitor cells (HSPC) that promote leukemic transformation KMT2Ar iALL using molecular, functional and vivo assays. First, comparing transcriptomes HSPC adult derived fetal-specific signature identified oncogene...
Background: Infant acute lymphoblastic leukaemia (iALL) has a dismal prognosis, and its characteristic MLL gene rearrangement (MLLr) invariably arises before birth. MLLr alone appears sufficient to transform human fetal liver haematopoietic cells suggesting that molecular programmes may co-operate with produce the aggressive phenotype of iALL. One such oncofetal gene, LIN28B is normally expressed exclusively birth but known be aberrantly in range malignancies. an RNA binding protein canonic...
Background: Favorable survival outcomes with CPX-351 vs conventional 7 + 3 and comparable safety in adults aged 60–75 years the pivotal phase trial (NCT01696084) led to approval of for newly diagnosed therapy-related acute myeloid leukemia (tAML) or AML myelodysplasia-related changes (AML MRC) US Europe. However, did not include patients <60 years, creating a data gap on potential effectiveness younger patients. The Real-world Effectiveness SafeTy (CREST-UK; NCT05169307) study evaluated use...
Background: There are a range of types influenza vaccines: Inactivated vaccines vary by number component virus strains, they trivalent (TIV) or quadrivalent (QIV) and given injection. Live attenuated vaccine (LAIV) is intranasal. Monitoring adverse events interests (AEIs) following vaccination recommended the European Medicines Agency (EMA) to monitor common detect infrequent but important interest (AEI).Methods: A retrospective cohort study computerised medical record data from Royal...
A strongly nuclear sequence space is exhibited whose strong dual normed.
A strongly nuclear sequence space is exhibited whose strong dual normed.