AIMTo evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc +/Min-FCCC mice with dextran sodium sulfate (DSS)-induced inflammation. METHODS Inflammation driven carcinogenesis was induced Apc+/Min-FCCC by administering DSS their drinking water.Mice were fed a diet supplemented (0-20 ppm) and its multiplicity histopathologically confirmed polypoid, Plecanatide-mediated activation guanylate cyclase-C suppresses

Our results indicate that plecanatide and dolcanatide, guanylate cyclase-C receptor agonists designed to replicate the activity of human intestinal peptide uroguanylin, maintain barrier function exhibit potent anti-nociceptive in animal models visceral hypersensitivity, suggesting a novel mechanism, beyond well described secretory function, for these treatment functional constipation disorders inflammatory bowel disease.

Abstract Context Gestational diabetes (GDM) has profound effects on the intrauterine metabolic milieu and is linked to obesity in offspring, but mechanisms driving these remain largely unknown. Alterations DNA methylation gene expression amniocytes exposed GDM utero represent a potential mechanism leading dysfunction later life. Objective To profile changes genome-wide human GDM. Design A nested case-control study (n = 14 pairs) was performed matched for offspring sex, maternal...

Prenatal exposure to bisphenol A (BPA) is linked obesity and diabetes but the molecular mechanisms driving these phenomena are not known. Alterations in deoxyribonucleic acid (DNA) methylation amniocytes exposed BPA utero represent a potential mechanism leading metabolic dysfunction later life.To profile changes genome-wide DNA expression second trimester human utero.A nested case-control study was performed matched for offspring sex, maternal race/ethnicity, age, gestational age at...

Background Most elderly patients suffer from multiple diseases and are on drugs for treatment. Polypharmacy in the elderly, physiological changes with old age, pharmacokinetics pharmacodynamic effects of many drugs, newer drug prescription trends like diabetes cardiovascular disease make prescribing more difficult. There chances drug-drug interactions easily available over-the-counter (OTC) medications. To prevent irrational use there is a need analysis studies. Prescription studies will...

Maxillomandibular fractures can be described as a complete or incomplete break causing discontinuity of the bone tissues in maxillary mandibular structures resulting from application an excessive force.The intimate relationship between maxillofacial with oral cavity, nasal orbits, and adjacent cranial make it functionally cosmetically important structure.Most etiological causes these are: road accidents, contact sport injuries, assaults, falls other industrial accidents.Several...

Introduction: Uroguanylin (UG) is an endogenous natriuretic peptide that binds and activates GC-C receptors located on the luminal side of GI tract to stimulate cGMP synthesis, a second messenger regulates electrolytes fluid transport, maintains epithelial cell homeostasis facilitates barrier function in tract. The biologically active UG (16 amino acid) assumes several distinct topological isomers aqueous solution only one those are active. Based thermal bond energy calculations, 3-D...

Introduction: Irritable bowel syndrome (IBS) is a gastrointestinal (GI) disorder with symptoms comprised of abdominal pain and alterations in habits. The key mechanism its pathophysiology considered to be visceral hypersensitivity, which could due loss barrier function gut permeability. GI inflammation might also contributory factor. Population-based studies have shown ˜10 fold higher risk inflammatory diseases IBS patients as compared those no prior history (Porter CK et al. BMC...

Background: Pregnancies complicated by gestational diabetes (GDM) or maternal obesity (MOB) induce abnormal fetal development that can lead to and later in life with sex specific manifestations. Alterations miRNA expression GDM MOB exposed offspring effects on have not been fully described. Hypothesis: Exposure an aberrant intrauterine milieu leads changes target gene human liver. Methods: Candidate was measured second trimester AF from women diagnosed via multiplex assay (Firefly Bioworks,...

The COVID-19 pandemic had imposed a city-level quarantine, local lockdown, and border closures for patient-level isolation to control virus spread. There is lack of studies on the health-related quality life (HRQoL) in elderly countries like India during COVID-19. After obtaining written informed consent from patients, data was recorded case record form-cum-questionnaire. assessed with help Centers disease prevention (CDC) HRQoL-14 measures, which are based general health improvement,...

Earlier identifying drug interactions may help in risk reduction elderly patients.Drug prescription data of 212 patients tertiary health care center had been analyzed for possible with investigational drugs COVID-19 treatment. Drug interaction checked from Stockley's Interaction 2019 and Martindale the Complete Reference 2017 standard reference books Pharmacology.Different types prescribed were 260 out which 68 (26.36%) category fixed-dose combinations. Around 150 (70.75%) having one or more...

Genetic factors contribute to 15% of all causes male infertility. Y chromosome microdeletion is the second most common genetic cause Screening important for Yq as defect can be transferred offspring. Aim our study detect frequency in idiopathic infertile men using both EAA and non markers central region India. Forty from infertility clinic, seeking treatment were recruited cases. Thirty normal fertile same origin controls. Semen analysis was done cytogenetic included study. Simplex multiplex...

Background MIRAGE syndrome is a rare multisystem disorder characterized by myelodysplasia, infection, growth restriction, adrenal hypoplasia, genital phenotypes, and enteropathy. The associated with mutations in Sterile Alpha Motif Domain Containing 9 (SAMD9) gene, encoding an endosome fusion facilitator protein additional function factor signaling. To date, there are no reported cases of severe insulin resistance infancy. Clinical Case patient was premature female infant born at 30 6/7...

Background: Gestational diabetes (GDM) has profound effects on the intrauterine metabolic milieu, induces marked abnormalities in fetal glucose and insulin secretion is linked to obesity offspring, but mechanisms remain largely unknown. Objective: To measure changes gene expression genome wide DNA methylation human amniocytes, a stem cell, exposed GDM utero. Methods: EdgeR identified differentially expressed genes from RNASeq via fold change, p-values, q-values calculated after Bonferoni...

Abstract Introduction MENIN and RET mutations in MEN1 families, are rare, and, when they co-exist either mutation may predominate the clinical picture. We report a family, with both mutations, suspect that not be an innocent bystander. Clinical Cases GM (36M): 2009: Presented skin lesions lactotroph adenoma causing chiasmal compression. Treatment: Hypophysectomy Cabergoline. This resulted restoration of sexual function fertility. 2013: Developed hyperparathyroidism [Calcium 10.6mg%...

Abstract Introduction The MEN 1 syndrome is an enigmatic disorder, manifesting a wide spectrum of disorders, in members family, harbouring the same gene mutation. We present one such with MENIN mutation marked diversity clinical presentation Clinical cases 1992: RB (Age: 13) presented accelerated puberty, galactorrhoea and lactotroph adenoma. Treated Bromocriptine, followed by hypophysectomy radiotherapy. He was on hormone replacement for hypopituitarism. 1996: gained 21 kg weight had...

Abstract Background Perfluorooctanoic acid (PFOA), is a persistent fluorinated compound with oil and water repelling properties found in cookware, food packaging municipal systems. Adult animals exposed to PFOA develop hepatomegaly, fatty liver, peroxisome proliferation, immunotoxicity. Rodents utero have altered hepatic lipid metabolism, increased de novo lipogenesis susceptibility non-alcoholic liver disease (NAFLD), but underlying molecular mechanisms remain unknown. With increasing rates...

Abstract Background: Perfluorooctanoic acid (PFOA), is a persistent fluorinated compound with oil and water repelling properties found in cookware, food packaging municipal systems. Adult animals exposed to PFOA develop hepatomegaly, fatty liver, peroxisome proliferation, immunotoxicity. Rodents PFCs utero have altered hepatic lipid metabolism, increased de novo lipogenesis susceptibility non-alcoholic liver disease (NAFLD), but underlying molecular mechanisms remain unknown. With increasing...

Abstract Background: Gestational diabetes (GDM) has profound effects on the intrauterine metabolic milieu, induces marked abnormalities in fetal glucose and insulin secretion is linked to obesity offspring, but mechanisms remain largely unknown. Epigenetic modifications stems cells may be one mechanism by which an utero exposure can lead development of later life. Objective: To identify novel pathways contributing offspring exposed GDM integrating data generated from transcriptome methylome...

<i>Background: </i>In the work up of male infertility, Y chromosome microdeletion screening is crucial. PCR a very sensitive technique to screen microdeletion. In current study, was detected by based technique. To best our knowledge, no such study has been reported from Chhattishgarh state India so far. <i>Material and methods:</i> A total seventy-three subjects were enrolled for during period one year. Out which forty-seven cases (infertile men with oligozoospermia azoospermia) twenty-five...