A5043253932- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Parasites and Host Interactions
- SARS-CoV-2 detection and testing
- Parasitic Diseases Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Digestive system and related health
- Viral gastroenteritis research and epidemiology
- Cancer, Stress, Anesthesia, and Immune Response
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- Research on Leishmaniasis Studies
- Peptidase Inhibition and Analysis
- Adenosine and Purinergic Signaling
- Pregnancy and Medication Impact
- Childhood Cancer Survivors' Quality of Life
- Inflammation biomarkers and pathways
- Topic Modeling
- Acute Lymphoblastic Leukemia research
- Bioactive Compounds and Antitumor Agents
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
Institute of Genomics and Integrative Biology
2020-2021
Baruch S. Blumberg Institute
2017
Fox Chase Cancer Center
2017
Drexel University
2013-2015
Hepatitis B Foundation
2011-2012
Post Graduate Institute of Medical Education and Research
2009-2011
The rapid emergence of coronavirus disease 2019 (COVID-19) as a global pandemic affecting millions individuals globally has necessitated sensitive and high-throughput approaches for the diagnosis, surveillance, determining genetic epidemiology SARS-CoV-2. In present study, we used COVIDSeq protocol, which involves multiplex-PCR, barcoding, sequencing samples detection deciphering We approach on 752 clinical in duplicates, amounting to total 1536 could be sequenced single S4 flow cell NovaSeq...
Pulmonary tuberculosis, the disease caused by Mycobacterium still retains a top rank among deadliest communicable diseases. Sputum expectorated during continues to be primary diagnostic specimen and also serves as reservoir of bacteria. The expression pattern mycobacteria in sputum will lead an insight into bacterial adaptation at most highly transmissible stage infection can help identifying newer well drug targets. Thus, present study, whole genome microarray tuberculosis was used...
Abstract Introduction: Till date, no drug has shown definite benefit in non-severe COVID-19. Ivermectin is an antiparasitic which in-vitro efficacy reducing coronavirus-2 (SARS-CoV-2) load severe disease. Objectives: To determine if a single oral administration of to patients with mild and moderate COVID-19 effective converting SARS-CoV-2 RT-PCR negative result viral load. Methods: In this double-blind trial, were randomized elixir formulation 24 mg, 12 mg or placebo 1:1:1 ratio. The...
Abstract The rapid emergence of coronavirus disease 2019 (COVID-19) as a global pandemic affecting millions individuals globally has necessitated sensitive and high-throughput approaches for the diagnosis, surveillance determining genetic epidemiology SARS-CoV-2. In present study, we used COVIDSeq protocol, which involves multiplex-PCR, barcoding sequencing samples detection deciphering We approach on 752 clinical in duplicates, amounting to total 1536 could be sequenced single S4 flow cell...
AIMTo evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc +/Min-FCCC mice with dextran sodium sulfate (DSS)-induced inflammation. METHODS Inflammation driven carcinogenesis was induced Apc+/Min-FCCC by administering DSS their drinking water.Mice were fed a diet supplemented (0-20 ppm) and its multiplicity histopathologically confirmed polypoid, Plecanatide-mediated activation guanylate cyclase-C suppresses
Treatment failure in leukemia is due to either pharmacokinetic resistance or cell drugs.Gene expression of multiple drug protein (MDR-1), multidrug resistance-related (MRP) and low (LRP) was assessed 45 pediatric ALL cases 7 healthy controls by real time PCR. The scored as negative, weak, moderate strong.The male female ratio 2.75:1 the mean age 5.2 years. Some 26/45 (58%) were standard risk, 17/45(38%) intermediate 2/45 (4%) high risk categorie, 42/45 (93%) being B-ALL recurrent...
Viral oncoprotein Tax plays key roles in transformation of human T cell leukemia virus (HTLV-1)-infected cells leading to adult (ATL), and is the antigen recognized during HTLV-associated myelopathy (HAM). In HLA-A2+ asymptomatic carriers as well ATL HAM patients, Tax(11-19) epitope exhibits immunodominance. Here, we evaluate immunotherapeutic potential this HLA-A2 transgenic mice presence absence dendritic (DCs) given recent encouraging observations made with Phase 1 DC-based vaccine trial...
Purpose: Uroguanylin (UG) is an endogenous peptide secreted into the GI lumen where it binds to guanylate cyclase C receptors (GC-C) and stimulates production of cGMP. Increased prodction cGMP activates cystic fibrosis transmembrane conductance regulator (CFTR), resulting in enhancement transepithelial efflux sodium, potassium, chloride water. We previously reported that expression UG dramatically reduced human colon polyps cancerous tissues. Oral treatment with also inhibited polyp...
Despite the widespread application of Large Language Models (LLMs) in biomedical research, their clinical adoption faces significant challenges. These challenges stem from concerns about quality, accuracy, and comprehensiveness LLM-generated answers. Most existing work has focused on fine-tuning LLMs based foundation models, which have not yet fully addressed accuracy reliability issues. In this work, we propose an agent-based approach that aims to make LLM-based systems clinically...
Background Certain oral bacterial pathogens may play a role in carcinogenesis. We assessed the feasibility of conducting population-based study India to examine distributions and levels Porphyromonas gingivalis , Fusobacterium nucleatum Prevotella intermedia relation leukoplakia (a potentially malignant disorder) other participant characteristics. Methods This exploratory case-control was nested within large urban Indian cohort data included 22 men women with (cases) 69 leukoplakia-free...
Abstract Colon cancer is one of the most prevalent malignancies in world; with an estimated 875,000 cases diagnosed worldwide; accounting for 8.5% all new cancers. Patients ulcerative colitis and Crohn's disease are at increased risk developing colorectal cancer. It believed that persistent gastrointestinal (GI) inflammation may contribute to carcinogenesis. The cGMP signaling mediates anti-inflammatory effects cellular molecules such as nitric oxide hemeoxygenase-1. Therefore, therapies...
Purpose: Uroguanylin (UG) is a peptide hormone produced in the GI tract lumen where it binds to Guanylate Cyclase C (GC-C), which results enhanced production of cyclic guanosine monophosphate (cGMP) and activation cystic fibrosis transmembrane conductance regulator (CFTR). Earlier we reported that UG expression suppressed human colon tumors oral treatment with inhibited not only formation adenomas but also their progression ApcMin/+ mice. Plecanatide (SP-304), highly potent analog UG,...
Individually, HLA-A2.1 and CD11c-DTR transgenic mouse strains have been used to investigate the immunopathogenesis of different viruses provided important insights into current understanding hostpathogen interactions during human T-cell leukemia virus type 1 (HTLV-1) infection. Here, these mice enabled study CD8 immune response against a known MHC class I HLA-A2.1-restricted epitope 11-19 viral oncoprotein Tax delivered along with tetanus helper peptide without or incomplete Freund’s...
Abstract Viral oncoprotein Tax plays key roles in transformation of human T cell leukemia virus (HTLV-1)-infected cells leading to adult (ATL), and is the antigen recognized during HTLV-associated myelopathy (HAM). In HLA-A2+ asymptomatic carriers as well ATL HAM patients, Tax(11-19) epitope exhibits immunodominance. Here, we evaluate immunotherapeutic potential this HLA-A2 transgenic mice presence absence dendritic (DCs) given recent encouraging observations made with Phase 1 DC-based...