A5103063772- Zebrafish Biomedical Research Applications
- Medical Imaging and Analysis
- Immune cells in cancer
- Esophageal and GI Pathology
- Trigeminal Neuralgia and Treatments
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Lanthanide and Transition Metal Complexes
- T-cell and B-cell Immunology
- Synthesis and properties of polymers
- Nanoparticle-Based Drug Delivery
- NF-κB Signaling Pathways
- Protein Tyrosine Phosphatases
- Tracheal and airway disorders
- Chemokine receptors and signaling
- Hand Gesture Recognition Systems
- Electrical and Bioimpedance Tomography
- Calpain Protease Function and Regulation
- Particle accelerators and beam dynamics
- Facial Nerve Paralysis Treatment and Research
- Healthcare and Venom Research
Ruijin Hospital
2009-2024
South China University of Technology
2021-2024
University of Science and Technology of China
2024
National Synchrotron Radiation Laboratory
2024
Shanghai Jiao Tong University
2010-2023
First Affiliated Hospital of University of South China
2023
University of South China
2023
Southern Medical University
2018
Second Military Medical University
2011
Shanghai Pudong New Area Gongli Hospital
2011
Abstract In Parkinson's disease (PD), iron elevation in specific brain regions as well selective loss of dopaminergic neurons is a major pathologic feature. A reliable quantitative measure deposition potential biomarker for PD and may contribute to the investigation iron‐mediated PD. The primary purpose this study assess variations multiple deep grey matter nuclei early with novel MRI technique, susceptibility mapping (QSM). inter‐group differences R2 * value nuclei, namely head caudate...
We compared a 4-limb bioelectrical impedance analysis (BIA) system, HBF 359 (Omron), and 2-limb foot-to-foot device, BC 532 (Tanita), with the standard dual energy X-ray absorptiometry (DXA) magnetic resonance imaging (MRI) methods for measurement of body fat percentage (BF), skeletal muscle mass (SMM, or fat-free [FFM] 532), visceral level (VF). Body composition was measured in 200 healthy volunteers (100 men 100 women, mean age 48 years) by DXA MRI. The agreement assessed correlation...
Abstract Granulomatous experimetal autoimmune thyroiditis (G-EAT) is induced in DBA/1 mice by adoptive transfer of mouse thyroglobulin (MTg)-primed spleen cells. TNF-α an important proinflammatory cytokine and apoptotic molecule involved many diseases. To study its role G-EAT, anti-TNF-α mAb was given to recipient mice. Disease severity comparable between with or without treatment at days 19–21, the time maximal suggesting not essential for development thyroid inflammation. However, lesions...
Abstract BACKGROUND Mild asymptomatic intracranial atherosclerotic stenosis (aICAS) is common in Chinese patients with hypertension. However, there are no data on its prognostic value this population. The aim of the present study was to clarify prevalence and associated cardiovascular risk factors mild aICAS determine for overall mortality METHODS In total, 1,813 participants were evaluated using computed tomographic angiography. predictive effect severe all-cause Kaplan-Meier survival...
Abstract When granulomatous experimental autoimmune thyroiditis (G-EAT) was induced in CBA/J or DBA/1 mice, thyroid lesions resolved less severe (3+) G-EAT wild-type mice (5+) IFN-γ−/− but progressed to fibrosis 5+ mice. To define the mechanisms leading these distinct outcomes, expression of inflammatory and apoptotic molecules infiltrating cells evaluated using immunohistochemistry, RT-PCR, confocal microscopy. The ratio CD4+/CD8+ T infiltrates one factor that predicted outcome. CD4+...
Transcription factor RUNX1 holds an integral role in multiple-lineage haematopoiesis and is implicated as a cofactor V(D)J rearrangements during lymphocyte development. Runx1 deficiencies resulted immaturity reduction of lymphocytes mice. In this study, we found that runx1 W84X/W84X mutation led to the disordering B cells, well failure cells but not T resulting antibody-inadequate-mediated immunodeficiency adult zebrafish. By contrast, cell development was affected. The decreased number...
The CCAAT enhancer binding protein alpha (CEBPA) is crucial for myeloid differentiation and the balance of haematopoietic stem progenitor cell (HSPC) quiescence self-renewal, its dysfunction can drive leukemogenesis. However, role in HSPC generation has not been fully elucidated. Here, we utilized various zebrafish cebpa mutants to investigate function Cebpa compartment. Co-localization analysis showed that expression enriched nascent HSPCs. Complete loss resulted a significant reduction...
Neutrophils play an essential role in the innate immune defense system vertebrates. During hematopoiesis, full function of neutrophils involves maturation granules and related enzymes. Yet, transcription regulators that promote neutrophil remain largely undefined. Here, two hematopoiesis-defective zebrafish mutants, runx1w84x c-mybhkz3, were used to investigate vivo roles Runx1 cooperation with c-Myb regulating maturation. Loss runx1 impairs primitive development. Additional regulation...
Abstract Severe granulomatous eperimental autoimmune thyroiditis (G-EAT) in DBA/1 or CBA/J wild type (WT) mice at day 19 progresses to fibrosis by 35, but severe G-EAT interferon (IFN)-γ−/− less-severe WT resolves 35. To study the role of chemokines diseases and fibrosis, profiles chemokine receptors were analyzed versus IFN-γ−/− thyroids, which have distinct outcomes inflammation. Gene expression CXC ligand 1 (CXCL1) receptor 2 (CXCR2) paralleled neutrophil infiltration thyrocyte...
Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin (MTg)-sensitized splenocytes activated with MTg and interleukin (IL)-12. Our previous studies showed that, when used as donors recipients, interferon (IFN)-gamma(-/-) wild-type (WT) DBA/1 mice both develop severe G-EAT. Thyroid lesions in IFN-gamma(-/-) have many eosinophils few neutrophils, while those WT extensive neutrophil infiltration eosinophils. consistently resolve day 40-50, whereas ongoing...
Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by transfer of mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg and anti-IL-2R or IL-12. Previous work suggested that IL-12 was required for development G-EAT. To determine whether also during the induction and/or effector phases, DBA/1 mice a disrupted IL-12-P40 gene (IL-12(-/-)) were used EAT induction. Cells from MTg-sensitized IL12(-/-) donors anti-IL2R severe recipient mice. Compared...
Zebrafish are widely used as experimental animal models. They small and move fast in the water. Real-time imaging of fast-moving zebrafish is a challenge, it requires that technique has higher spatiotemporal resolution penetration ability. The purpose this study was to evaluate feasibility dynamic phase retrieval (PR)-based phase-contrast (PCI) for real-time displaying breathing swimming process unanesthetized free-moving zebrafish, PR-based CT (PCCT) visualizing soft tissues anesthetized...
Abstract The single nonlinear kicker (NLK) injection has been adopted by several synchrotron radiation light source facilities or their upgrades. injected beam receives a kick from an NLK and goes into the acceptance of storage ring while stored passes through center where magnetic field is almost zero. Compared with local-bump injection, requires less space for kickers causes disturbance to during injection. Currently, conventional local bump including four pulsed dipole magnets in HLS-II...