A5000275978- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Adolescent and Pediatric Healthcare
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Pharmaceutical studies and practices
- Telemedicine and Telehealth Implementation
- IL-33, ST2, and ILC Pathways
- Pancreatitis Pathology and Treatment
- Photoacoustic and Ultrasonic Imaging
- Diagnosis and treatment of tuberculosis
- Mobile Health and mHealth Applications
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Biosimilars and Bioanalytical Methods
- Advanced Biosensing Techniques and Applications
- Diverticular Disease and Complications
- COVID-19 and healthcare impacts
- Leprosy Research and Treatment
Vanderbilt University Medical Center
2011-2024
University of Chicago
2015-2018
Crohn's disease (CD) is a complex chronic inflammatory disorder with both gastrointestinal and extra-intestinal manifestations associated immune dysregulation. Analyzing 202,359 cells from 170 specimens across 83 patients, we identify distinct epithelial cell type in terminal ileum ascending colon (hereon as 'LND') high expression of LCN2, NOS2, DUOX2 genes related to antimicrobial response immunoregulation. LND cells, confirmed by in-situ RNA protein imaging, are rare non-IBD controls but...
Abstract BACKGROUND: Procoagulant states, leading to activation of the coagulation protease thrombin, are common in cancer and portend a poor clinical outcome. Although procoagulant states osteosarcoma patients have been described, studies exploring cells' ability directly contribute activity not reported. This study explores hypothesis that can regulate thrombin generation proliferate response attenuating with anticoagulants slow tumor growth. METHODS: Pathologic analysis adjacent venous...
Introduction The need to rapidly implement telehealth at large scale during the COVID-19 pandemic led many patients using for first time. We assessed effect of structured pre-visit preparatory telephone calls on success visits and examined risk factors unsuccessful visits. Methods A retrospective cohort study was carried out 45,803 adult scheduled a total 64,447 appointments between March July 2020 an academic medical center. subset received phone call. Demographic inclusion call were...
This study evaluated synchronous audiovisual telehealth and audio-only visits for patients with inflammatory bowel disease (IBD) to determine frequency of successful what factors increase the likelihood completion.Data were collected from March July 2020 in a tertiary care adult IBD clinic that was transitioned fully model. A protocol implemented. retrospective analysis performed using electronic medical record (EMR) data. All scheduled video telehealth. If this failed, providers attempted...
Crohn's disease (CD) is a complex chronic inflammatory disorder that may affect any part of gastrointestinal tract with extra-intestinal manifestations and associated immune dysregulation. To characterize heterogeneity in CD, we profiled single-cell transcriptomics 170 samples from 65 CD patients 18 non-inflammatory bowel (IBD) controls both the terminal ileum (TI) ascending colon (AC). Analysis 202,359 cells identified novel epithelial cell type TI AC, featuring high expression
Abstract BACKGROUND & AIMS Crohn’s disease (CD) is a chronic inflammatory with complex pathogenesis; treatment and management largely depend on activity assessment, which can be challenging invasive. The aim of this study was to assess the ability multiplex Luminex technology identify serum cytokine and/or chemokine markers activity. METHODS Serum samples were prospectively obtained from 103 CD 40 healthy controls undergoing colonoscopy. determined by histologic assessment colonoscopic...
The present study aimed to investigate the role of blood supply in early tumorigenesis colorectal cancer. We leveraged renin angiotensin system (RAS) alter colonic and determine effect on tumor initiation progression.To test tumorigenesis, 53 male A/J mice were randomly assigned one three RAS modulation groups two AOM treatments. I) water (RAS-unmodulated) as a control group, II) angiotensin-II III) receptor blocker, Losartan. each group then split into either saline condition or AOM-treated...
Polyarteritis nodosa (PAN) is a necrotizing vasculitis commonly affecting small-sized vessels and medium-sized vessels. We present the case of surgical resection for ischemic colitis secondary to PAN. A 26-year-old woman presented with left lower quadrant pain, diarrhea bloody stools. Colonoscopy showed diffuse circumferential ulceration necrotic lining from sigmoid colon splenic flexure. subsequent computed tomography angiography (CTA) revealed colonic wall thickening, hypoenhancement...
A Functional Medicine program was developed at an inflammatory bowel disease (IBD) center with the goal of integrating strategies to address modifiable lifestyle factors and complete a 6-week elimination diet under direction trained dietitian providers.From January 2019 November 2019, patients controlled, but persistent, symptoms from IBD were offered enrollment. Each 5 visits incorporated educational session focused on nutrition followed by focusing factors. The placed supervised diet. At...
Abstract INTRODUCTION Telehealth care in the ambulatory setting has dramatically increased COVID and post-COVID period medicine. Understanding how this may impact of patients (pts) with inflammatory bowel disease (IBD) is important. This study aims to evaluate pattern use telehealth a tertiary IBD center. METHODS Pts seen at center from January 2018 March 2020 August 2023 were included. between July excluded as institution had mandatory visits during period. Data was obtained Electronic...
Abstract Background When it comes to readiness transition an adult subspecialty clinic, perspectives between patients with inflammatory bowel disease (IBD) and their caregivers may differ influence the ability successfully transition. Patients IBD have been shown suffer from poor transfers of care. There is a need more efficiently accurately assess improve transfer process. Methods transferring clinic were each administered Transition Readiness Assessment Questionnaire Self-Efficacy...
<title>Abstract</title> Introduction: Patient reported outcomes (PRO) including patient disease activity scores, quality of life, and depressive symptoms are increasingly being used for clinical care in patients with inflammatory bowel (IBD). However, little is known about performance PROs over time a real-world setting. Methods: were collected from tertiary IBD center the electronic medical records (EMR) 2018–2020. Quality life was measured Simple Inflammatory Bowel Disease Questionnaire...
Introduction: Non-adherence to self-injectable biologic therapy in patients with inflammatory bowel disease (IBD) is common (one national study reported 56% adherence) and negatively impacts clinical outcomes.1 This analysis evaluated adherence rates health outcomes across three academic centers integrated specialty pharmacies.1. Govani S, Noureldin M, Higgins P, et al. Am J Gastroenterol. 2018;113:276 Methods: We performed a retrospective cohort of adult IBD receiving care at tertiary...