- Tracheal and airway disorders
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- Pneumonia and Respiratory Infections
- Neonatal and Maternal Infections
- Neonatal Respiratory Health Research
- Cardiovascular and Diving-Related Complications
- Kawasaki Disease and Coronary Complications
- Pancreatic function and diabetes
- Congenital Diaphragmatic Hernia Studies
- Soil and Unsaturated Flow
- Lower Extremity Biomechanics and Pathologies
- RNA Interference and Gene Delivery
- Food Allergy and Anaphylaxis Research
- COVID-19 Impact on Reproduction
- Diabetes Management and Research
- Viral Infectious Diseases and Gene Expression in Insects
- Connective tissue disorders research
- Soil Moisture and Remote Sensing
- Preterm Birth and Chorioamnionitis
- Syphilis Diagnosis and Treatment
- Esophageal and GI Pathology
- Autoimmune and Inflammatory Disorders Research
- Neurological diseases and metabolism
- Cell Adhesion Molecules Research
Kwansei Gakuin University
2024
Nissan Chemical Corporation (Japan)
2022-2023
Musashino Red Cross Hospital
2015-2023
Shinshu University
2018
Sojo University
2015
National Defense Medical College
2011
Background: The tibial tubercle deviation associated with recurrent patellar dislocation (RPD) has not been studied sufficiently. New methods of evaluation were used to verify the extent in a group compared that control group, frequency patients who demonstrated cutoff value indicating transfer was warranted on basis distribution, and validity these for diagnosing RPD. Methods: Sixty-six history (single 19 [SPD group] 47 [RPD group]) 66 age sex-matched controls analyzed use computed...
We are developing a wide-field X-ray monitor onboard the HiZ-GUNDAM mission. is future satellite mission for gamma-ray burst observation to lead time domain astronomy and multi-messenger astronomy. The pnCCD detectors will be used as focal plane detector, which back-illuminated CCD fully depleted by reverse-biased pn-junctions on front back sides. It has high sensitivity low-energy X-rays achieves frame rate with column-parallel readout. was originally developed astronomy, its radiation...
Three children developed severe encephalopathy associated with human herpesvirus 6 infection. Magnetic resonance imaging of the brain showed either basal ganglia involvement or diffusion abnormalities in cerebral white matter. Coagulopathy hypercytokinemia was observed 2 patients. One demonstrated thermolabile variation carnitine palmitoyltransferase 2. These results suggest a heterogeneous pathogenic mechanism
Background . Delayed diagnosis and treatment of newborn infection adversely impact outcomes. Clinical laboratory parameters have aimed to obtain the most correct prompt this disease. This study simultaneously observed changes over time in APR as well proinflammatory cytokines anti-proinflammatory aims clarify usefulness scores. Methods We evaluated acute phase reactants (APR) 46 newborns whose serum up age 7 days had been stored, with comparison three types (Group I: 15, Group F: fetal...
Leukemoid reaction (LR) is a reactive disease that exhibits abnormal blood values similar to leukemia, but not due leukemia. One report showed neonatal LR (NLR) was associated with elevated serum granulocyte colony stimulating factor (G-CSF) in only 30% of the study neonates. NLR always elevation G-CSF. defined as white cell count ≥ 40 × 103/μL and/or blast concentration > 2%. We have focused on fetal inflammatory response syndrome (FIRS), systemic triggered by intrauterine infection. FIRS...
In recent years, the aging of agricultural workers has progressed rapidly, successor problem is becoming more serious. Under such circumstances are coming out also new farmers that will beginner to agriculture. However, establishment farming technology become a major management challenge for farmers. this study, we focused on fact compensate water part challenges (establishment technology), build soil moisture measurement system due sensor. addition, clarification irrigation amount and...
Mesenchymal stem cell (MSC) transplantation, in particular allogeneic is a promising therapy for variety of diseases. However, before performing allograft treatment it necessary to find suitable donors, establish culture methods that maintain quality, and reduce production costs. Here, we present new method producing MSCs combining human umbilical cord-derived mesenchymal cells (UCMSCs) chitin-based polysaccharide fibers (Cellhesion® MS). UCMSC numbers significantly increased, grew as...
Anti-HLA antibodies reportedly exist in the one third of pregnant women. But few occurrences neonatal alloimmune thrombocytopenia (NAIT) caused by anti-HLA have been reported. Here a male baby, who was admitted for low birth weight with Down syndrome (DS), suffered from without transient myeloproliferative disorder (TMD). Positive reactions HLA-specific were detected maternal serum. Cross-matching tests between serum and paternal platelets lymphocytes strongly positive. It is most...
Transient late-onset hyperglycemia was detected in a very low birth weight (VLBW) infant (gestational age 28 weeks, 1,082 g) by routine point-of-care glucose monitoring. The had no clinical symptom. Serial continuous monitoring (CGM) conducted for 3 days at 31, 35, and 39 weeks’ post conceptual age. difference values between the maximum minimum blood levels during interval from one enteral feeding to next were 32.3±14.3 mg/dL, 47.5±22.9 27.5±12.9 mg/dL 1st, 2nd, 3rd CGM, respectively. serial...
We report a male infant with birthweight of 1,400 g at 29 weeks 2 days gestation diagnosed as having cow's milk allergy (CMA) due to human fortifier, who developed severe respiratory symptoms. The had no gastrointestinal symptoms; rather, the initial symptoms were apnea attacks and wheezing prolonged expiratory phase that progressed ventilatory insufficiency requiring mechanical ventilation. Aggravation his general condition, which appeared be sepsis, was improved by temporary starvation...
We encountered a very rare case of fulminant necrotizing enterocolitis (F-NEC) in preterm male baby. The course NEC and sepsis this was clearly different from the usual course. After onset at 14 days life, catheter-related bloodstream infection first assumed, antibiotics γ-globulin administration were started. However, 12 hours after onset, baby's abdominal distension increased remarkably, his entire wall turned red to purple. Escherichia coli isolated blood culture, but catheter tip culture...
Case ReportA 6-month-old girl was admitted to the intensive care unit of a tertiary pediatric hospital for shortness breath and respiratory distress three days following one month cough.A er ve antibiotics therapy (amoxicillin sulbactam followed by meropenem two days), chest CT scan showed severe pneumonia with local consolidation.A beroptic bronchoscopy alveolar lavage, she intubated ventilation transported ambulance our because persistent cyanosis.e gravida 2 para vaginal delivered...
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We report the cytokine profiles of an infant with congenital syphilis as a first case. This female was born by vaginal delivery at gestational age 27 weeks during her mother’s treatment for syphilis. Elevation T helper (Th)-1 cytokines (interleukin (IL)-2, IL-12) and IL-17, which supports immunological mechanisms Th-1, similar to that in cases adults. IL-6 granulocyte colony-stimulating factor (G-CSF), synergistic effects cause leukemoid reaction, were also elevated. The levels interferon-γ...
High mobility group box 1 (HMGB-1) has been extensively studied in adults and to a certain extent neonates as well. Clinical examination of neonates, especially unwell soon after birth, should be minimally invasive.This study aimed investigate whether the urinary HMGB-1 level is comparable serum neonates.In all, 87 (37.5 ± 2.9 weeks gestation mean birth weight 2588 649 g) were enrolled. Of these, 53 males 34 females. The umbilical cord blood first or second spontaneous voiding urine samples...
A 768 g female neonate, born at 25 weeks' gestation, developed sepsis due to methicillin-resistant Staphylococcus epidermidis on day 14. Severe thrombocytopenia was observed, and hemophagocytic macrophages were identified in her peripheral blood smear. Cytokine profiles the time of onset suggested that an inflammatory cytokine storm had activated lymphocytes macrophages, leading platelet phagocytosis. After administration vancomycin for 14 days immunoglobulin therapy, she improved without...
The development of stridor and periodic desaturation in a 2-day-old neonate born at term lead to the suspicion upper airway obstruction. patient underwent flexible fiberoptic laryngo-tracheo-bronchoscopy was diagnosed as having an elongated soft palate secondary mild pharyngomalacia. Early intervention with high PEEP therapy using nasal CPAP led improvement condition.
We experienced a female infant weighing 866 g at birth after 28 weeks 1 day gestation with apparent intrauterine infection. Bi-level-nasal CPAP was selected for respiratory management as strategy to minimize the severity of chronic lung disease (CLD). As result, she survived acute phase without tracheal intubation and improved requiring home oxygen therapy. Her urinary β2 microglobulin (u-BMG) in early neonatal period less than cutoff value 100,000 μg/gCr onset CLD. However, her u-BMG then...