A5091839651- Bioactive Natural Diterpenoids Research
- Plant-based Medicinal Research
- Marine Sponges and Natural Products
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Renal and related cancers
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer-related molecular mechanisms research
- Chemical synthesis and alkaloids
- Mycobacterium research and diagnosis
- Advanced Synthetic Organic Chemistry
- Spaceflight effects on biology
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Ideological and Political Education
- PI3K/AKT/mTOR signaling in cancer
- Tuberculosis Research and Epidemiology
- Planarian Biology and Electrostimulation
- Electromagnetic Fields and Biological Effects
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- RNA Research and Splicing
Guangzhou Institutes of Biomedicine and Health
2020-2025
Chinese Academy of Sciences
2020-2025
Guangzhou Medical University
2025
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2023
University of Chinese Academy of Sciences
2023
Sun Yat-sen University
2012-2018
Heilongjiang Center for Tuberculosis Control and Prevention
2017
The transcription factor c-Myc is important in cell fate decisions and frequently overexpressed cancer cells, making it an attractive therapeutic target. Natural compounds are among the current strategies aimed at targeting c-Myc, but their modes of action still need to be characterized. To explore mechanisms underlying anticancer activity a natural diterpenoid, oridonin, we conducted miRNA expression profiling statistical analyses that strongly suggested was potential molecular target...
miR-372/373, a cluster of stem cell-specific microRNAs transactivated by the Wnt pathway, has been reported to be dysregulated in various cancers, particularly colorectal cancer (CRC); however, unique role these remains discovered. In present study, we characterized upregulation expression miR-372/373 CRC tissues from The Cancer Genome Atlas data, and then showed that overexpression enhanced stemness cells enriching CD26/CD24-positive cell population promoting self-renewal, chemotherapy...
The static magnetic fields (SMFs) impact on biological systems, induce a variety of responses, and have been applied to the clinical treatment diseases. However, underlying mechanisms remain largely unclear. In this report, by using human mesenchymal stem cells (MSCs) as model, we investigated effect SMFs at molecular cellular level. We showed that SMF exposure promotes MSC proliferation activates expression transcriptional factors such FOS (Fos Proto-Oncogene, AP-1 Transcription Factor...
Highlights•Isolation of gpEpiSCs resembling E10.5–E11.5 epiblasts from embryos•gpEpiSC self-renewal depends on FGF2, ACTIVIN A, and WNT signaling inhibition•gpEpiSCs show transcriptional features the primed pluripotent stateSummaryGuinea pigs are valuable models for human disease research, yet lack established stem cell lines has limited their utility. In this study, we isolate characterize guinea pig epiblast cells (gpEpiSCs) post-implantation embryos. These differentiate into three germ...
Somatic cells can be reprogrammed into pluripotent stem (iPSCs) by overexpressing defined transcription factors. Specifically, overexpression of OCT4 alone has been demonstrated to reprogram mouse fibroblasts iPSCs. However, it remains unclear whether any other single factor induce iPSCs formation. Here, we report that SALL4 alone, under an optimized reprogramming medium iCD4, is capable Mechanistically, facilitates inhibiting somatic genes and activating genes, such as Esrrb Tfap2c....
The giant panda ( Ailuropoda melanoleuca ) stands as a flagship and umbrella species, symbolizing global biodiversity. While traditional assisted reproductive technology faces constraints in safeguarding the genetic diversity of pandas, induced pluripotent stem cells (iPSCs) known for their capacity to differentiate into diverse types, including germ cells, present transformative potential conservation endangered animals. In this study, primary fibroblast were isolated from panda, iPSCs...
Objective: To understand the genotype distribution of Mycobacterium tuberculosis and drug susceptibility M. with different genotypes in Changping district Beijing evaluate application genotyping local (TB) prevention control. Methods: A total 1 099 strains isolated from 2011 to 2015 were used. Spoligotyping 12-locus VNTR recommended by Gao used for these isolates. In addition, isolates rifampin (RFP), isoniazid (INH), ethambutol (EMB), streptomycin (SM), amikacin (AMK) ofloxcin (OFX)...
Abstract The CREB1 gene encodes a pleiotropic transcription factor that frequently dysregulated in cancers. can regulates tumour cell status of proliferation or migration, however, the molecular basis for this switch involvement plasticity has not been fully understood. Here, we show knocking out triggered remarkable effect epithelial-mesenchymal transition (EMT) and led to occurrence inhibited enhanced motility cancer cells. Mechanistically, CREB1-knockout cells showed arrest G0/G1 phase as...
<div>Abstract<p>The transcription factor c-Myc is important in cell fate decisions and frequently overexpressed cancer cells, making it an attractive therapeutic target. Natural compounds are among the current strategies aimed at targeting c-Myc, but their modes of action still need to be characterized. To explore mechanisms underlying anticancer activity a natural diterpenoid, oridonin, we conducted miRNA expression profiling statistical analyses that strongly suggested was...
<p>PDF file - 71K</p>
<p>PDF file - 33K, Oridonin increases Fbw7 expression after short-term treatment.</p>
<p>PDF file - 72K, Efffects of oridonin on expression mature miRNAs and pri-miRNAs in K562 cells.</p>
<p>PDF file - 58K, Regulation of oridonin on c-Myc.</p>
<p>PDF file - 83K, description on the methods used in Supplementary Table S3.</p>
<p>PDF file - 71K</p>
<p>PDF file - 83K, description on the methods used in Supplementary Table S3.</p>
<p>PDF file - 72K, Efffects of oridonin on expression mature miRNAs and pri-miRNAs in K562 cells.</p>
<p>PDF file - 58K, Regulation of oridonin on c-Myc.</p>
<p>PDF file - 33K, Oridonin increases Fbw7 expression after short-term treatment.</p>