A5080512991- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Trace Elements in Health
- Advanced biosensing and bioanalysis techniques
- TGF-β signaling in diseases
- Pharmacogenetics and Drug Metabolism
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Protein Structure and Dynamics
- Advanced Drug Delivery Systems
- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- Metabolism and Genetic Disorders
- Drug-Induced Hepatotoxicity and Protection
- Vitamin C and Antioxidants Research
- Isotope Analysis in Ecology
- Cancer, Lipids, and Metabolism
- Hemoglobin structure and function
- Microfluidic and Capillary Electrophoresis Applications
- Iron Metabolism and Disorders
- Hormonal and reproductive studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Surgical Sutures and Adhesives
- Orthopedic Infections and Treatments
- Connective Tissue Growth Factor Research
University Hospital in Motol
2023-2025
Charles University
2022-2025
Research Institute of Inorganic Chemistry
2023
Heidelberg University
2017-2020
University Hospital Heidelberg
2017-2020
University Medical Centre Mannheim
2017-2020
Medizinische Fakultät Mannheim
2018
TGF-β2 (TGF-β, transforming growth factor beta), the less-investigated sibling of TGF-β1, is deregulated in rodent and human liver diseases. Former data from bile duct ligated MDR2 knockout (KO) mouse models for cholestatic disease suggested an involvement biliary-derived As we also found upregulated TGFB2 tissue patients with primary sclerosing cholangitis (PSC) biliary (PBC), now fathomed positive prospects targeting early stage using MDR2-KO mice. Specifically, influence TgfB2 silencing...
ABSTRACT Hemoglobinopathies, hereditary disorders affecting the structure or production of hemoglobin, were detected by routine HbA 1c measurements capillary electrophoresis (CE) at University Hospital Motol, Prague. The potential ultraviolet–visible (UV–Vis) and Fourier‐transform infrared (FTIR) spectroscopy for detection characterization hemoglobinopathies was investigated. FTIR spectra recorded with a very high resolution (0.5 cm −1 ) 128 scans. broad amide I peak, located 1700–1600 , can...
Urolithiasis is one of the most frequently occurring diseases worldwide. Its management related on investigation concretion composition which helps to assess current therapy. Fourier-transform infrared (FTIR) spectrometry gains significant importance because its ability determine composition. Presented review shows use FTIR spectroscopy in detection very rare urinary stones including cyanoacrylate and pyrophosphate. Infrared made possible identify nature concretions helped urolithiasis.
This study explored the short-term effects of vitamin K2 (VK2) supplementation on biochemical parameters (vitamin D, E, A, alkaline phosphatase, calcium, phosphorus (P), magnesium, metallothionein, triglycerides, cholesterol, high-density lipoprotein (HDL), low-density (LDL), and fractions (albumin, HDL, very (VLDL), LDL, chylomicrons). A experiment (24 h, six probands) was performed to track changes in VK2 levels after a single-dose intake (360 µg/day). Liquid chromatography-tandem mass...
Malignant liver tumors are highly aggressive with a poor prognosis. Metalothionein (MT) is low-molecular intracellular protein, whose primary function to regulate the homeostasis of heavy metals in many organisms. There only few studies focusing on molecular mechanisms MT expression. Recent show its significant relations carcinogenesis, spontaneous mutagenesis and efficiency antitumor medicine. In previous studies, increase levels cancer patients was proven. The aim this work study as well...
Metallothionein (MT) is a low molecular weight intracellular protein, the primary function of which to maintain homeostasis heavy metals in living organisms. Only few research has been carried on topic mechanism MT. Recent points its significant relationship carcinogenesis, spontaneous mutagenesis, and effectiveness antitumor drugs. Increased level MT studied as potential indicator increased metabolic activity cancer. Electrochemical methods are suitable analytical tool for detection....
Multiresistant bacterial strains are a very serious clinical problem in hospital environment.Solving these types of nosocomial infections requires new and unique approaches.It is known that vancomycin an antibiotic used for the treatment such as S. aureus strains.Nanomedicine using nanotechnologies brings options like application surface coating modifications targeting treatment.Superparamagnetic iron oxide nanoparticles (SPION) particles were created by physicochemical method synthesis.For...
Since the only therapy of end-stage liver disease still is transplantation, need for an early treatment in stage fibrosis becoming more important.
Since the only therapy of end-stage liver disease still is transplantation, need for an early treatment in stage fibrosis becoming more important. The transforming growth factor (TGF)-β has been identified as a master regulator fibrogenesis.