A5031015577- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Disease Mechanisms and Treatments
- Cardiovascular and exercise physiology
- Advanced Glycation End Products research
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Congenital heart defects research
- Heart Rate Variability and Autonomic Control
- High Altitude and Hypoxia
- NF-κB Signaling Pathways
- Protease and Inhibitor Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Long-Term Effects of COVID-19
- Nitric Oxide and Endothelin Effects
- Biomarkers in Disease Mechanisms
- Stress Responses and Cortisol
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 diagnosis using AI
- Acute Myocardial Infarction Research
- Apelin-related biomedical research
- SARS-CoV-2 detection and testing
Army Medical University
2008-2023
Xinqiao Hospital
2007-2021
Louisiana State University Health Sciences Center Shreveport
2009-2019
Pennsylvania State University
2017
Creative Commons
2015
May Institute
2015
Louisiana State University in Shreveport
2012
Austrian Academy of Sciences
2011
Phosphoinositide 3-kinase (PI3K)-γ is linked to inflammation and oxidative stress. This study was conducted investigate the role of PI3Kγ in blood-brain barrier dysfunction brain damage induced by focal cerebral ischemia/reperfusion.Wild-type knockout mice were subjected middle artery occlusion (60 minutes) followed reperfusion. Evans blue leakage, edema, infarct volumes, neurological deficits examined. Oxidative stress, neutrophil infiltration, matrix metallopeptidase-9 assessed. Activation...
Recent work has revealed an essential involvement of soluble CD40L (sCD40L) in inflammation and vascular disease. Activated platelets are the major source sCD40L, which been implicated platelet leukocyte activation, although its exact functional impact on leukocyte-platelet interactions underlying mechanisms remain undefined. We aimed to determine sCD40L neutrophils. studied neutrophil with activated, surface-adherent as a model for recruitment sites injury. Our data show that contributes...
Objective— Vascular smooth muscle cells (VSMCs) phenotype modulation is critical for the resolution of vascular injury. Genetic and pharmacological inhibition PI3Kγ (phosphoinositide 3-kinase γ) exerts anti-inflammatory protective effects in multiple cardiovascular diseases. This study investigated role its downstream effector molecules regulation VSMC phenotypic neointimal formation response to Approach Results— Increased expression was found injured vessel wall as well cultured,...
Endothelial progenitor cells (EPCs), a CXCR4-bearing cell line, are thought to positively influence reendothelialization, vascular repair, and angiogenesis. AMD3100, highly selective antagonist of stromal derived factor (SDF)-1 that binds its receptor, CXCR4, has been shown induce rapid mobilization hematopoietic stem in mice, dogs, humans. Results this study indicate AMD3100 injection can potent EPCs mice compared with saline injection. The demonstrates murine spleen-derived produce high...
Despite extensive investigations, restenosis, which is characterized primarily by neointima formation, remains an unsolved clinical problem after vascular interventions. A recent study has shown that CD40 signaling through TNF receptor associated factor 6 (TRAF6) plays a key role in formation carotid artery injury; however, underlying mechanisms are not clearly elucidated. Because may vary significantly depending on the type of injury, we first assessed effect deficiency 2 injury models,...
It has been shown that CD40-TRAF6 axis in leukocytes plays a significant role neointimal formation after carotid ligation. Because CD40 and TRAF6 are expressed not only but also vascular cells, we examined the of contributed by wall cells ligation an atherogenic environment.
Abstract Background The novel coronavirus disease 2019 (COVID-19) spreads rapidly among people and causes a pandemic. It is of great clinical significance to identify COVID-19 patients with high risk death. Methods A total 2169 adult were enrolled from Wuhan, China, February 10th April 15th, 2020. Difference analyses medical records performed between severe non-severe groups, as well survivors non-survivors. In addition, we developed decision tree model predict death outcome in patients....
Object: The receptor for advanced glycation end products (RAGE) may play an important role in inflammatory processes and endothelial activation, likely to accelerate the of atherosclerosis, especially patients with diabetes. factors that regulate expression RAGE are not completely clear. C-reactive protein (CRP) is identified as a key proinflammatory cytokine atherosclerosis. Atherosclerosis also induces reduction dysfunction progenitor cells (EPCs), main cell type vascular repair....
Appetite loss is a common symptom that occurs in high altitude (HA) for lowlanders. Previous studies indicated hypoxia the initiating vital factor of HA appetite loss. PPARA, EPAS1, EGLN1, HIF1A, HIF1AN, and NFE2L2 play important roles hypoxic responses. We aimed to explore association these hypoxia-related gene polymorphisms with In this study, we enrolled 416 young men who rapidly ascended Lhasa (3700 m) from Chengdu (<500m) by plane. were genotyped MassARRAY. scores measured identify...
<i>Background/Aims:</i> Human coronary artery-derived endothelial cells (ECs) seem to be the most appropriate for pathogenesis study of artery disease. But limited availability tissue is a major constraint. In this study, we developed method isolate human ECs in vivo from patients. <i>Methods:</i> Coronary guidewires were used obtain EC samples arteries 76 Cells eluted wire tips and purified by immunomagnetic beads. Von Willebrand factor CD31 as immunocytochemical...
Hypercholesterolemia impairs the quantity and function of endothelial progenitor cell. We hypothesized that glycogen synthase kinase 3β activity is involved in regulating biological cells hypercholesterolemia microenvironment. For study, derived from apolipoprotein E-deficient mice fed with high-fat diet were used. Glycogen was interfered inhibitor lithium chloride or transduced replication defective adenovirus vector expressing catalytically inactive (GSK3β-KM). Functions cells,...
Background Cardiorespiratory fitness plays an important role in coping with hypoxic stress at high altitudes. However, the association of cardiorespiratory development acute mountain sickness (AMS) has not yet been evaluated. Wearable technology devices provide a feasible assessment fitness, which is quantifiable as maximum oxygen consumption (VO2max) and may contribute to AMS prediction. Objective We aimed determine validity VO2max estimated by smartwatch test (SWT), can be...
Despite the potential of endothelial progenitor cells (EPCs) to incorporate into sites vessel injury and differentiate cells, thereby contributing improvement function, reendothelialization in some patients is insufficient for prevention abnormal growth because there a lack specific guided signals low levels congregation EPCs injured areas. If type molecular tool was able guide specifically vessels, however, then efficacy cell implantation would improve. Here, we designed strategy modify...