A5101849309- High Altitude and Hypoxia
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Autophagy in Disease and Therapy
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Alkaloids: synthesis and pharmacology
- Sleep and Wakefulness Research
- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- Vestibular and auditory disorders
- Circadian rhythm and melatonin
- Parkinson's Disease Mechanisms and Treatments
- Magnetic properties of thin films
- Physics of Superconductivity and Magnetism
- Climate Change and Health Impacts
- Chromatography in Natural Products
- Bioactive Compounds and Antitumor Agents
- Sphingolipid Metabolism and Signaling
- Glutathione Transferases and Polymorphisms
- Shape Memory Alloy Transformations
- Single-cell and spatial transcriptomics
- Cancer, Lipids, and Metabolism
- Computational Drug Discovery Methods
Army Medical University
2018-2025
Guangzhou University of Chinese Medicine
2023-2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Dalian Medical University
2025
Shanghai University
2023
Wuhan University of Science and Technology
2023
Xinqiao Hospital
2021-2022
Chinese People's Liberation Army
2021-2022
Shandong University of Traditional Chinese Medicine
2019-2022
Disturbances in lipid metabolism and dysbiosis of the gut microbiota play an important role progression hyperlipidemia. Previous study indicated that Ilicis Rotundae Cortex possesses anti-hyperlipidemic activity, rotundic acid (RA) identified as a key active compound to be incorporated into body. The aimed evaluate anti-hyperlipidemia effects RA explored its impact on metabolism, well possible mechanisms for improving methodology included comprehensive evaluation steatosis markers...
Abstract Statins play a major role in reducing circulating cholesterol levels and are widely used to prevent coronary artery disease. Although they recently confirmed up-regulate mitophagy, little is known about the molecular mechanisms its effect on endothelial progenitor cell (EPC). Here, we explore mechanism underlying statin (pitavastatin, PTV)-activated mitophagy EPC proliferation. ApoE −/− mice fed high-fat diet for 8 weeks induce atherosclerosis. In these mice, proliferation decreases...
Hypobaric hypoxia (HH) is the primary challenge at highland. Prolonged HH exposure impairs right cardiac function. Mitochondria-associated membrane (MAM) plays a principal role in regulating mitochondrial function under hypoxia, but mechanism was unclear. In this study, proteomics analysis identified that PACS2, key protein MAM, and mitophagy were downregulated HH. Metabolomics indicated suppression of glucose fatty acids aerobic oxidation conditions. Cardiomyocyte Pacs2 deficiency disrupted...
Circadian rhythms play a fundamental role in the progression of cardiovascular events. Almost all diseases have circadian misalignment usually characterized by changes metabolites. This study aimed to dynamically monitor rhythmic biomarkers, elucidate metabolic pathways that are potentially under control spontaneously hypertensive rats (SHRs), and eventually establish phenotype strategy based on metabolomics.In this study, an untargeted metabolomics technology was used serum metabolites...
Cardiorespiratory function influences exercise capacity and is an important determinant of high-altitude adaptation. Some studies have investigated the characteristics changes in cardiorespiratory fitness during acclimatization. However, on de-acclimatization are still lacking not yet been elucidated. Furthermore, few drugs studied to improve both processes. The Shigatse CARdiorespiratory Fitness (SCARF) study a single-center, randomized, double-blind, placebo-control clinical trial explore...
Uncaria rhynchophylla (Miq.) Miq. ex Havil is widely used in the treatment of hypertension. The extract, and its bioactives, rhynchophylline isorhynchophylline; reduced blood pressure fatty content liver cells. In present study, anti-hypertensive effects ethanol extract (UET), (RT) isorhynchophylline (IT) were investigated spontaneously hypertensive rats (SHR) using UPLC-Q-Orbitrap/MS based lipidomics approach . Histological changes evaluated. Cytolysis degeneration tissues observed SHR...
Background High-altitude exposure changes the electrical conduction of heart. However, reports on electrocardiogram (ECG) characteristics and potent prophylactic agents during high-altitude acclimatization de-acclimatization are inadequate. This study aimed to investigate effects ubiquinol electrophysiology after hypoxia reoxygenation. Methods The was a prospective, randomized, double-blind, placebo-controlled trial. Forty-one participants were randomly divided into two groups receiving 200...
Abstract Chaenomeles Fructus is a plant that can be used for both food and medicine. Modern studies have shown has anti‐inflammatory immunosuppressive effects on arthritis. However, the mechanism of action rheumatoid arthritis (RA) its main active ingredients are still unclear. This study was aimed at devising an integrated strategy investigating bioactivity constituents possible pharmacological mechanisms against RA. The components were analyzed using UPLC‐Q‐Exactive orbitrap MS techniques...
Background: Acute high-altitude (HA) exposure results in blood pressure (BP) and cardiac function variations most subjects, some of whom suffer from acute mountain sickness (AMS). Several previous studies have found that cardiovascular indicators are potentially correlated with AMS. Objectives: This study aims to examine HA-induced adaptations AMS patients compare them healthy subjects. It also investigate the relationship between AMS, as well provide insightful information about prevention...
Insufficient cardiorespiratory compensation is closely associated with acute hypoxic symptoms and high-altitude (HA) cardiovascular events. To avoid such adverse events, predicting HA fitness impairment (HA-CRFi) clinically important. However, to date, there insufficient information regarding the prediction of HA-CRFi. In this study, we aimed formulate a protocol predict individuals at risk We recruited 246 volunteers who were transported Lhasa (HA, 3,700 m) from Chengdu (the sea level [SL],...
Left atrial appendage (LAA) thrombus detachment resulting in intracranial embolism is a major complication of fibrillation (AF). Endocardial endothelial cell (EEC) injury leads to thrombosis, whereas autophagy protects against EEC dysfunction. However, the role and underlying mechanisms EECs during AF have not been elucidated. In this study, we isolated from model mice observed reduced autophagic flux intracellular calcium concentrations mice. addition, detected an increased expression...
Atrial fibrillation (AF) is associated with an increased risk of thrombosis the left atrial appendage (LAA). However, molecular mechanisms underlying this site-specificity remain poorly understood. Here, we present a comparative single-cell transcriptional profile paired appendages from patients AF and illustrate chamber-specific properties main cell types.Single-cell RNA sequencing analysis matched samples three persistent was evaluated by 10× genomics. The mice model created using Tbx5...
Background Cardiorespiratory fitness plays an important role in coping with hypoxic stress at high altitudes. However, the association of cardiorespiratory development acute mountain sickness (AMS) has not yet been evaluated. Wearable technology devices provide a feasible assessment fitness, which is quantifiable as maximum oxygen consumption (VO2max) and may contribute to AMS prediction. Objective We aimed determine validity VO2max estimated by smartwatch test (SWT), can be...
Background: Acute high altitude (HA) exposure results in blood pressure (BP) variations most subjects. Previous studies have demonstrated that higher BP is potentially correlated with acute mountain sickness (AMS). The load may be of clinical significance regarding systemic circulation status. Objectives: This study aimed to examine HA-induced changes patients AMS compared those healthy Further, we provided information about the relationship between 24-h ambulatory parameters (BP level,...
Background: The neurotransmitter metabolism in spontaneously hypertensive rats (SHR) is disordered, and these disturbances levels can further exacerbate the development of hypertension. Neurotransmitters affect expression circadian clock genes. Objective: To clarify time-dependent internal mechanism imbalance target metabolic rhythm rats, research was carried out by method targeted metabolomics molecular biology technology. Methods: We have explored isorhynchophylline regulating through ERK...
In the present study, we aimed to use metabolomics platforms examine circadian-regulated neurotransmitters across a 24-h day and effects of Uncaria administration on daily rhythmicity in order establish strategy for evaluating spatiotemporal efficacy evaluation Uncaria. By using targeted ultrahigh performance liquid chromatography-mass spectrometry metabolomics, quantified 32 neurotransmitter metabolites every 4 h over 24 h. To assess metabolite rhythmicity, performed cosinor analysis. The...
Background Acute high altitude (HA) exposure elicits blood pressure (BP) responses in most subjects, and some of them suffer from acute mountain sickness (AMS). However, a 24-h ambulatory BP (ABP) change the correlation with occurrence AMS different sexes are still unclear. Objectives This prospective study aimed to investigate HA induced males females relationship between ABP. Methods Forty-six subjects were matched according demographic parameters by propensity score matching ratio 1:1....