A5069085100- Nutrition and Health in Aging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Body Composition Measurement Techniques
- Nutritional Studies and Diet
- Frailty in Older Adults
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- Calpain Protease Function and Regulation
- Hydrogen's biological and therapeutic effects
- Autophagy in Disease and Therapy
- Stress Responses and Cortisol
- Neurological disorders and treatments
- Biochemical effects in animals
- Bone Metabolism and Diseases
- Barrier Structure and Function Studies
- RNA modifications and cancer
- Bone health and osteoporosis research
- Pleural and Pulmonary Diseases
- Hippo pathway signaling and YAP/TAZ
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cardiac pacing and defibrillation studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tryptophan and brain disorders
- Thermoregulation and physiological responses
Union Hospital
2024-2025
Huazhong University of Science and Technology
2024-2025
Wuhan Union Hospital
2024
Union Hospital
2024
Wuhan University
2017-2021
Zhongnan Hospital of Wuhan University
2017-2021
Jiangxi Provincial People's Hospital
2021
Shanghai Institute of Hypertension
2011
Idiopathic pulmonary fibrosis (IPF) is a chronic and usually progressive lung disease the epithelial-mesenchymal transition (EMT) may play an important role in pathogenesis of fibrosis. IL-17 proinflammatory cytokine which promotes EMT profiles inflammatory diseases. In this study, we investigated effect on alveolar epithelial cell line A549 TGFβ1-Smad ERK signaling pathways process. Morphological observation cells was performed under inverted microscope. The mRNA protein expressions E-cad...
Calpains are intracellular calcium-dependent cysteine proteases, which cleave several substrates proteins, have been proven to play important roles in lung fibrosis. The aim of this study was investigate the effects calpain on bleomycin (BLM)-induced pulmonary A fibrosis mice model established successfully by intraperitoneal injection bleomycin. Calpeptin, a highly selective inhibitor activation, administered three times weekly after injection. Histological examination used assess...
Despite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still remain poorly understood. The aberrantly activated lung myofibroblasts, predominantly emerging through fibroblast-to-myofibroblast differentiation, are considered to be key cells in PF, resulting excessive accumulation of extracellular matrix (ECM). Latent transforming growth factor-β (TGFβ) binding protein-2 (LTBP2) has been suggested as playing a critical role modulating structural integrity ECM....
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease with poor prognosis. Epithelial-mesenchymal transition (EMT) has been reported to play an important role in IPF. The extracellular signal-regulated kinases 1 and 2 (ERK1/2) cascade, which regulates EMT oncogenesis, implicated the pathogenesis of Calpains, Ca2+-dependent cysteine proteinases that mediate controlled proteolysis many specific substrates including epithelial cell marker E-cadherin, participate organ fibrosis....
Background: Smoking participates in pathogenesis of lung cancer. Long non-coding RNAs (lncRNAs) play some specific roles during development cancers. Objective: To investigate effects smoking on lncRNA alterations Methods: There are 522 adenocarcinoma (LUAD) and 504 squamous cell carcinoma (LUSC) participants. Clinical genetic data were downloaded from The Cancer Genome Atlas (TCGA) database. LncRNA analyzed cancer patients. category packs evaluated. Correlations between analyzed....
The aim of this study was to investigate whether triglyceride glucose-body mass index (TyG-BMI) plays a mediating role between obstructive sleep apnoea syndrome (OSAS) and hypertension. analyzed clinical data from total 840 OSAS patients at Wuhan Union Hospital January 2020 December 2023. association TyG-BMI hypertension examined using restricted cubic spline regression logistic regression. Mediation effect analysis conducted explore the relationship OSAS, TyG-BMI, risk Severe associated...
To investigate the long-term effect of biventricular (BIV) and right ventricular apical (RVA) pacing on cardiac function in patients with high-degree atrioventricular block (AVB) left ejection fraction(LVEF)over 35%.A total 118 consecutive AVB six hospitals from East China between May 2009 December 2012 were enrolled this randomized, double-blind parallel controlled study. Patients randomly assigned to BIV RVA or without LV lead after one-week resynchronization therapy (CRT). Cardiac...
Objective: Numerous articles and reviews addressing the intersection of Chronic Obstructive Pulmonary Disease (COPD) with sarcopenia have been documented. However, a significant gap exists in literature concerning scientometric analysis this field. This study aimed to concentrate on recent research elucidate emerging areas through examination COPD sarcopenia. Methods: Articles field were systematically retrieved from Web Science Core Collections (WoSCC) spanning 2003 2022. The employed...
Emerging evidence suggests that systemic inflammatory and nutritional biomarkers, along with derived indices, could serve as predictors for sarcopenia in cancer population. This study aimed to compare these predictors, focusing on the risk index (NRI) evaluate its diagnostic value, sarcopenic patients without cancer.
Employing body composition analysis, this study aims to examine the influencing factors and conduct predictive analysis regarding sarcopenia incidence in middle-aged elderly population China.
The scientometric analysis was aim to focus on recent studies and clarify new research directions hypertension with sarcopenia. We hope provide comprehensive insights or actionable recommendations for clinicians policymakers.
<b>Background:</b> Epithelial-mesenchymal transition (EMT) is considered to play an important role in the pathogenesis of pulmonary fibrosis. <b>Objective:</b> The aim study was investigate calpain how regulate EMT and signaling pathway <b>Methods:</b> Mice were treated with bleomycin (BLM) or without calpeptin. HE staining micro-CT used assess PD150606, another inhibitor, performed type II alveolar epithelial cells (AEC II) mice. Cells collected for western blot analysis after TGF-β1...