A5074899600- Dermatology and Skin Diseases
- Gut microbiota and health
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Ocular Infections and Treatments
- Ocular Surface and Contact Lens
- Antibiotic Resistance in Bacteria
- Oral microbiology and periodontitis research
- Pediatric health and respiratory diseases
- Sinusitis and nasal conditions
Chinese University of Hong Kong
2019-2025
Prince of Wales Hospital
2023
Abstract Background Allergic rhinoconjunctivitis (ARC) is a prevalent allergic condition in the pediatric population. Microbial dysbiosis has increasingly been recognized to influence on host immunity and diseases. However, microbial profile of ARC not characterized. This cross‐sectional study aims evaluate changes nasal ocular surface microbiome children with ARC. Methods Ocular nasopharyngeal swabs were collected from controls cases for 16S rRNA amplicon sequencing. The bacterial community...
Eczema is a major allergic disease in children, which particularly prevalent Chinese children during their first year of life. In this study, we showed that alterations the infant gut microbiota precede development eczema prospective cohort. particular, discovered enrichments genera Clostridium sensu stricto 1 and Finegoldia cases at 3 month age, respectively, may represent potential targets for intervention to prevent eczema. Besides, identified depletion Bacteroides from 6 months age an...
International travel increases the risk of acquisition antibiotic-resistant bacteria and antibiotic resistance genes (ARGs). Previous studies have characterized changes in gut microbiome resistome Western travellers; however, information on non-Western populations effects travel-related factors remains limited.
Eczema is a common inflammatory skin disorder during infancy. Evidence has shown that skin-microbiome fluctuations may precede eczema development, but their predictive value for phenotypes remains unknown. We aimed to investigate the early-life evolution of microbiome and its temporal associations with different pairs (transient versus persistent, atopic non-atopic) in Chinese children. followed 119 term infants from birth 24 months old within Hong Kong cohort. The microbes at left...
<h3>Background</h3> Eczema is a common skin inflammatory disorder during infancy. An increasing number of studies have shown an association between eczema and microbiome fluctuations. Skin dysbiosis was reported to precede the onset infant by both culture-based sequencing-based analyses. However, pathophysiology highly complex heterogenous. Given that umbrella term for atopic (IgE-associated) non-atopic (non-IgE-associated) forms eczema, whether plays important role in determining subtypes...
<h3>Background</h3> Eczema is a common skin inflammatory disease during infancy. Most paediatric patients develop eczema within 6 months of age, but the severity and persistence vary. While infantile in most cases could improve or get resolved with some children may follow relapsing persistent course. The underlying decisive early-life factor not yet known. An increasing number studies have shown an association between microbiome fluctuations. Evidence has revealed gut eczema, currently...