A5052821380- Ophthalmology and Eye Disorders
- Vestibular and auditory disorders
- RNA modifications and cancer
- Muscle Physiology and Disorders
- Cerebral Palsy and Movement Disorders
- Ophthalmology and Visual Impairment Studies
- MicroRNA in disease regulation
- Retinal Imaging and Analysis
- Neurogenesis and neuroplasticity mechanisms
- Corneal surgery and disorders
- Knee injuries and reconstruction techniques
- Cancer-related gene regulation
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Circular RNAs in diseases
- Glaucoma and retinal disorders
- Nerve injury and regeneration
- Silk-based biomaterials and applications
- Oral microbiology and periodontitis research
- Retinal Development and Disorders
- Endoplasmic Reticulum Stress and Disease
- Prion Diseases and Protein Misfolding
- Cancer-related molecular mechanisms research
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
Chinese University of Hong Kong
2023-2025
Sun Yat-sen University
2020-2021
Abstract Retinoblastoma (RB) is a common intraocular malignancy in children. Due to the poor prognosis of RB, it crucial search for efficient diagnostic and therapeutic strategies. Studies have shown that methyltransferase‐like 3 (METTL3), major RNA N (6)‐adenosine methyltransferase, closely related initiation development cancers. Nevertheless, whether METTL3 associated with RB remains unexplored. Therefore, we investigated function mechanisms regulation progression. We manipulated...
This study aims to investigate the regulatory effect of circRNA_010763 on growth and invasion non-small cell lung cancer (NSCLC).qRT-PCR was performed detect expressions c-Myc in human NSCLC tissues cells. CCK-8 assay evaluate A549 cells proliferation transwell migration. The correlation between miR-715 detected by statistical analysis. Bioinformatics prediction Luciferase were explore interaction binding site miR-715, c-Myc, respectively.We found that both upregulated qRT-PCR showed...
To assess the cellular and molecular effects of lidocaine on muscles/myoblasts.Cultured myogenic precursor (C2C12) cells were treated with varying concentrations lidocaine.Cell viability C2C12 was inhibited by in a concentration-dependent manner, ≥0.08%, producing dramatic reduction cell viability. These ≥0.08% arrested cycles G0/G1 phase. Moreover, migration processes at low concentrations. Results from QRT-PCR assays revealed that following treatment lidocaine, Notch1, Notch2, Hes1, Csl...
Abstract Purpose and background Recently, we found that maximal medial rectus recession lateral resection in patients with complete paralysis resulted a partial restoration of abduction. In an attempt to understand some the mechanisms involved this effect examined gene expression profiles recti from these patients, our focus being directed genes related myogenesis. Materials methods Lateral resected those concomitant esotropia (controls) were collected. Differences between two groups using...
<b><i>Introduction:</i></b> Paralytic strabismus involves a functional loss of extraocular muscles resulting from muscular or neuronal disorders. Currently, only limited number drugs are available for repair muscles. Here, we investigated the effects novel drug, flavonoids sophoranone, on differentiation as assessed in both<i></i>in vivo and vitro models. <b><i>Materials Methods:</i></b> The effect sophoranone C2C12 cells was...