A5101785044- Axial and Atropisomeric Chirality Synthesis
- RNA Research and Splicing
- Photosynthetic Processes and Mechanisms
- Lung Cancer Treatments and Mutations
- Digestive system and related health
- Molecular spectroscopy and chirality
- Gold and Silver Nanoparticles Synthesis and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Plant Stress Responses and Tolerance
- Asymmetric Synthesis and Catalysis
- RNA and protein synthesis mechanisms
- Meat and Animal Product Quality
- Plant-Microbe Interactions and Immunity
- Nonlinear Waves and Solitons
- Carcinogens and Genotoxicity Assessment
- Genetic factors in colorectal cancer
- Plant Disease Management Techniques
- Advanced biosensing and bioanalysis techniques
- DNA Repair Mechanisms
- Spectroscopy and Chemometric Analyses
- Asymmetric Hydrogenation and Catalysis
- Molecular Biology Techniques and Applications
- Coconut Research and Applications
- Cancer Genomics and Diagnostics
- Biosensors and Analytical Detection
Shanghai Institute of Organic Chemistry
2014-2025
State Key Laboratory of Organometallic Chemistry
2025
Zhejiang Normal University
2023-2024
Xi'an Jiaotong University
2019-2022
Chinese Academy of Sciences
2014
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2014
Hangzhou First People's Hospital
2011
Axially chiral heterobiaryl serves as a core skeleton for bioactive molecules, ligands and organocatalysts. Enantioselective de novo formation of the heteroaromatic ring is one most straightforward approaches to access enantioenriched heterobiaryls. Herein, an enantioselective construction isoquinolines via rhodium‐catalyzed C−H activation/annulation aromatic imines with alkynes disclosed. This approach operationally simple, allowing rapid variety axially 1‐aryl in excellent yields...
Drought is one of the most serious stresses affecting rice growth. stress causes accelerated senescence, reduced fertility, and subsequent reductions in crop yield. Eukaryotic translation elongation factor EF1A an important multifunctional protein that plays essential role eukaryotic proteins. In this study, we localized cloned OsEF1A gene (Oryza sativa) order to clarify its drought tolerance Subcellular localization revealed it was mainly cell membrane, cytoskeleton nucleus. Compared with...
3位含有季碳手性中心的吲哚啉并环化合物是一类非常重要的化合物, 广泛存在于各种天然产物和具有生物活性的分子中. 化学家们发展了多种有效的途径来合成这类化合物. 其中以方便易得的吲哚衍生物为起始原料, 利用不对称去芳构化\环化串联的方法最为简单高效, 但多数工作都是从色胺或色醇衍生物出发, 合成二氢吡咯并吲哚啉或二氢呋喃并吲哚啉化合物. 因此, 发展其他类型的吲哚衍生物的不对称去芳构化\环化反应显得非常有必要. 作者课题组发展了手性磷酸催化的吲哚衍生物与甲基乙烯基酮的不对称Michael加成\环化串联反应. 以5 mol% (R)-SPINOL为骨架的手性磷酸(R)-4c为催化剂, 以中等到良好的收率和优秀的对映选择性构建了一系列手性吲哚[2,3-b]并氢化喹啉化合物, 而且该催化体系对于克级规模反应同样能够获得很好的结果.
Based on the role of Ku80 in mediating radiation-induced DNA repair, we investigated expression human lung cancers different pathological types and evaluated effect radiotherapy levels a mouse model. We used immunohistochemistry real-time PCR to determine protein mRNA levels, respectively. inoculated nude mice with A549 cells subjected tumor-bearing varying doses irradiation. Lung carcinoma tissue exhibited higher when compared normal tissue. Among tumor subtypes, adenocarcinoma squamous...
Inexpensive industrial paraffin wax is often coated on the surface of apples to keep them fresh; however, this material toxic and harmful human health. Currently, convenient effective methods detect residues are unavailable. Here a Raman spectroscopy-based technique reported identify paraffin-waxed apples, quantitative detection model was established. An 8 × point scan with an area 0.16 mm2 conducted construct three-dimensional map concentration distribution waxed before after washing, as...
The stem tips of Zizania latifolia at different development stages were used as research materials. expression stability nine candidate reference genes (ACT1, H2B, UBI, EF-1α, GAPDH, β-actin, 60S, SKIP and AQP) evaluated using qRT-PCR. data analyzed with GeNorm NormFinder software. Present results indicated that the ACT1 was stable it could be optimal gene for studying stage gall formation. selected to verify level correlative in formation Z. latifolia. Our consistent previous transcriptome...
Low temperature affects rice growth and yield. Receptor-like protein kinases play an important role in plant development. In order to reveal the of a leucine-rich receptor like kinase LRK2 low stress development rice. this study, we used obtained overexpressing plants for experiments results show that cold tolerance yield were higher than wild type. has high homology with phytosulfokine receptors (PSKRs) gene different species, is responsive (PSK). addition, observed proline content was...
Background: Circulating tumor DNA (ctDNA) is a kind of cell-free which comes from cells and effectively reflects the molecular characteristics tumors, providing us novel method to explore its clinical therapeutic value in advanced lung cancer. Methods: A total 36 patients with non-small cell cancer (NSCLC) were enrolled this study, including 28 cases adenocarcinoma 8 squamous carcinoma. Next-generation sequencing based ctDNA detection, tissue (tDNA) corresponding survival analysis,...