A5083776779- Inflammatory Bowel Disease
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Digestive system and related health
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Microscopic Colitis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peroxisome Proliferator-Activated Receptors
- Clinical Nutrition and Gastroenterology
- Parasites and Host Interactions
- Child Nutrition and Feeding Issues
- Cancer Research and Treatments
- Escherichia coli research studies
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Infant Nutrition and Health
- Hepatitis C virus research
- Vitamin C and Antioxidants Research
- Congenital gastrointestinal and neural anomalies
- Probiotics and Fermented Foods
- Infant Health and Development
- Liver Disease and Transplantation
- Inflammatory mediators and NSAID effects
Université de Lille
2007-2024
Paris Biotech Santé
2014-2024
Institut de Biologie de Lille
2013-2018
Lille Inflammation Research International Center
2017
Université Lille Nord de France
2011-2014
Inserm
2005-2013
Centre Hospitalier Universitaire de Lille
2011
Agence des Systèmes d’information Partagés de Santé
2009
Hôpital Claude Huriez
2006-2007
Physiopathologie et Epidémiologie des Maladies Respiratoires
2007
5-aminosalicylic acid (5-ASA) is an antiinflammatory drug widely used in the treatment of inflammatory bowel diseases. It known to inhibit production cytokines and mediators, but mechanism underlying intestinal effects 5-ASA remains unknown. Based on common activities peroxisome proliferator–activated receptor-γ (PPAR-γ) ligands 5-ASA, we hypothesized that this nuclear receptor mediates therapeutic action. To test possibility, colitis was induced heterozygous PPAR-γ+/− mice their wild-type...
<h3>Objective</h3> Mesenteric fat hyperplasia is a hallmark of Crohn9s disease (CD), and C reactive protein (CRP) correlated with activity. The authors investigated whether mesenteric adipocytes may be source CRP in CD inflammatory bacterial triggers stimulate its production by adipocytes. <h3>Design</h3> expression the subcutaneous fats patients correlation between plasma concentrations messenger RNA (mRNA) levels were assessed. impact challenges on synthesis was tested using an adipocyte...
Intestinal fibrosis is mainly associated with Crohn's disease and defined as a progressive excessive deposition of extracellular matrix components. No specific antifibrotic therapies are available. In this study, we evaluate the effect novel 5-ASA analog able to activate peroxisome proliferator-activated receptor γ, named GED-0507-34 Levo.Colonic was induced in 110 C57BL/6 mice by 3 cycles 2.5% (wt/vol) dextran sulfate sodium administration for 6 weeks. The preventive effects oral daily GED...
Adherent invasive Escherichia coli [AIEC] are recovered with a high frequency from the gut mucosa of Crohn's disease patients and believed to contribute dysbiosis pathogenesis this inflammatory bowel disease. In context, bacteriophage therapy has been proposed for specifically targeting AIEC in human no deleterious impact on commensal microbiota.The vitro efficacy specificity seven lytic phage cocktail [EcoActive™] was assessed against [i] 210 clinical strains, [ii] 43 non-E. strains...
Intestinal helminth parasites are potent inducers of T helper type 2 (Th2) response and have a regulatory role, notably on intestinal inflammation. As infection with schistosomes is unlikely to provide reliable treatment inflammatory bowel diseases, we investigated the beneficial effect schistosome enzymatic protein, 28-kDa glutathione S-transferase (P28GST), modulation disease activity immune responses in experimental colitis. Our results showed that immunization recombinant P28GST at least...
Irritable bowel syndrome (IBS) is one of the most frequent and debilitating conditions leading to gastroenterological referrals. However, recommended treatments remain limited, yielding only limited therapeutic gains. Chitin-glucan (CG) a novel dietary prebiotic classically used in humans at dosage 1.5-3.0 g/d considered safe food ingredient by European Food Safety Authority. To provide an alternative approach managing patients with IBS, we performed preclinical molecular, cellular, animal...
Epidemiological evidences suggested that 5-aminosalicylic acid (5-ASA) therapy may prevent the development of colorectal cancer in inflammatory bowel disease patients. Our aim is to investigate whether peroxisome proliferator-activated receptor-γ (PPARγ) mediates antineoplastic effects 5-ASA. HT-29 and Caco-2 cells were treated by 5-ASA, rosiglitazone (PPARγ ligand) or etoposide (anticarcinogenic drug). Epithelial cell growth, proliferation apoptosis assessed count, Ki-67 staining terminal...
The therapeutic management of Crohn's disease (CD), a chronic relapsing-remitting inflammatory bowel (IBD), is highly challenging. Surgical resection sometimes necessary procedure even though it often associated with postoperative recurrences (PORs). Tofacitinib, an orally active small molecule Janus kinase inhibitor, anti-inflammatory drug meant to limit PORs in CD. Whereas bidirectional interactions between the gut microbiota and relevant IBD are crucial, little known about impact...
Report25 September 2017Open Access Source DataTransparent process Peroxisome proliferator-activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut Mathurin Fumery U995—LIRIC—Lille Inflammation Research International Center, Univ. Lille, France Inserm, U995, Service d'Hépatogastroentérologie, Centre Hospitalier Universitaire d'Amiens, Université de Picardie Jules Verne, Amiens, Search for more papers by this author Silvia Speca Audrey Langlois Anne-Marie Davila...
Background P28GST, a 28Kd glutathione S-transferase enzymatic protein derived from schistosome helminth prevents experimental colitis when administered subcutaneously in the presence of adjuvant by decreasing pro-inflammatory Th1/Th17 response. Given antioxidant properties we evaluated its anti-inflammatory potential locally after induction absence adjuvant. Methods Colitis was induced BALB/c mice rectal administration TNBS, followed two intraperitoneal injections P28GST at day 1 and 2. Mice...
A 12-year-old female Irish Setter was examined because of recurrent episodes hindlimb weakness. The dog not ataxic, but had generalized muscular atrophy, decreased patellar reflexes, and slow proprioception. Blood glucose content low (32 mg/dl) the amended insulin-glucose ratio high (9,600). Electromyographic studies showed evidence polyneuropathy. diagnosis functional islet B-cell tumor with peripheral neuropathy. Exploratory laparotomy performed. Widespread metastases were observed...
BACKGROUND Irritable bowel syndrome (IBS), defined according to the Rome IV diagnostic criteria, is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related altered habits. First-line recommended treatments are limited combining drugs targeting predominant symptoms, particularly (antispasmodics), constipation (laxatives), and diarrhea (loperamide), yielding only therapeutic gain. GASTRAP® DIRECT class IIa medical formulation composed of combination...
Infection of mice with Citrobacter rodentium serves as a model to study human intestinal infections. C. infection leads increased production inflammatory cytokines, immune cell infiltration and damage the gut barrier. We used this colitis evaluate therapeutic properties OM-X®, an extract prepared by fermentation vegetables, seaweeds, fruits mushrooms. Administration OM-X® rodentium-infected reduced epithelium, lowered inflammation scores, IL-10 expression maintained FoxP3 gene expression....
The development of more effective, better tolerated drug treatments for progressive pulmonary fibrosis (of which idiopathic is the most common and severe form) a research priority. peroxisome proliferator-activated receptor gamma (PPAR-γ) key regulator inflammation therefore represents potential therapeutic target. However, use synthetic PPAR-γ agonists may be limited by their potentially adverse effects. In mouse model bleomycin (BLM)-induced fibrosis, we have demonstrated that non-racemic...