Asritha Tubati
A5026028849- Autoimmune Neurological Disorders and Treatments
- Multiple Sclerosis Research Studies
- RNA regulation and disease
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- Peripheral Neuropathies and Disorders
- Viral Infections and Vectors
- Cell Adhesion Molecules Research
- Complement system in diseases
- Peptidase Inhibition and Analysis
- Epilepsy research and treatment
- Cytomegalovirus and herpesvirus research
- Systemic Lupus Erythematosus Research
- Metabolomics and Mass Spectrometry Studies
- 14-3-3 protein interactions
- Immunotoxicology and immune responses
- Viral Infections and Outbreaks Research
- Neuroscience and Neuropharmacology Research
- T-cell and B-cell Immunology
University of California, San Francisco
2023-2024
The Royal Melbourne Hospital
2023
Montreal Neurological Institute and Hospital
2023
McGill University
2023
Kaiser Permanente Santa Rosa Medical Center
2023
Peter Doherty Institute
2023
St Vincent's Hospital
2023
The University of Melbourne
2023
Vitamin B12 is critical for hematopoiesis and myelination. Deficiency can cause neurologic deficits including loss of coordination cognitive decline. However, diagnosis relies on measurement vitamin in the blood, which may not accurately reflect concentration brain. Using programmable phage display, we identified an autoantibody targeting transcobalamin receptor (CD320) a patient with progressive tremor, ataxia, scanning speech. Anti-CD320 impaired cellular uptake cobalamin (B12) vitro by...
Objective Co‐occurring anti‐tripartite motif‐containing protein 9 and 67 autoantibodies (TRIM9/67‐IgG) have been reported in only a very few cases of paraneoplastic cerebellar syndrome. The value these biomarkers the most sensitive methods TRIM9/67‐IgG detection are not known. Methods We performed retrospective, multicenter study to evaluate cerebrospinal fluid serum candidate by tissue‐based immunofluorescence, peptide phage display immunoprecipitation sequencing, overexpression cell‐based...
Abstract Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum Repository (DoDSR), cohort over 10 million individuals, was used to generate whole-proteome profiles hundreds patients with MS (PwMS) years before and subsequently after onset. This analysis defines unique cluster PwMS that share an signature against common motif has similarity many human pathogens. These exhibit...
Abstract Vitamin B12 is critical for hematopoiesis and myelination. 1 Deficiency can cause neurologic deficits including loss of coordination, spasticity, cognitive decline. 2,3,4 However, diagnosis relies on vitamin measurement in the blood which may not accurately reflect levels brain. Here, we discovered an autoimmune deficiency restricted to central nervous system (CNS), termed (ABCD). Using programmable phage display, identified autoantibody targeting transcobalamin receptor (CD320) a...
To assess the effects of secreted factors from human B cells on neuronal viability in vitro.
Mutations in the complement factor I (CFI) gene have previously been identified as causes of recurrent CNS inflammation. We present a case 26-year-old man with 18 episodes meningitis, who had variant CFI(c.859G>A,p.Gly287Arg) not associated neurologic manifestations. He achieved remission canakinumab, human monoclonal antibody targeted at interleukin-1 beta.