A5044988770- Advanced NMR Techniques and Applications
- Solid-state spectroscopy and crystallography
- Antibiotic Resistance in Bacteria
- Force Microscopy Techniques and Applications
- Electron Spin Resonance Studies
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Physics of Superconductivity and Magnetism
- Lipid Membrane Structure and Behavior
- Magnetic and transport properties of perovskites and related materials
- Advanced Condensed Matter Physics
- NMR spectroscopy and applications
- Bacterial Genetics and Biotechnology
- Synthesis and Characterization of Heterocyclic Compounds
- Vibrio bacteria research studies
- Chemical Synthesis and Analysis
- Ferroptosis and cancer prognosis
- Nanopore and Nanochannel Transport Studies
- Quinazolinone synthesis and applications
- Biochemical and Molecular Research
- Photodynamic Therapy Research Studies
- Phagocytosis and Immune Regulation
- Bacteriophages and microbial interactions
- Advanced MRI Techniques and Applications
Shantou University
2025
First Affiliated Hospital of Shantou University Medical College
2025
Tongji University
2025
Minzu University of China
2024
Jiangnan University
2023-2024
Hubei University of Medicine
2022-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2020-2023
Shanghai Clinical Research Center
2023
Taihe Hospital
2007-2023
Shanghai University of Traditional Chinese Medicine
2020-2023
The Kondo lattice Hamiltonian with ferromagnetic Hund's coupling as a model for manganites is investigated. classical limit the spin of (localized) $t_{2g}$ electrons analyzed on lattices dimension 1,2,3 and $\infty$ using several numerical methods. phase diagram at low temperature presented. A regime identified where separation occurs between hole undoped antiferromagnetic hole-rich regions. Experimental consequences this novel are discussed. Regions incommensurate correlations have also...
Avibactam is a β-lactamase inhibitor that in clinical development, combined with β-lactam partners, for the treatment of bacterial infections comprising Gram-negative organisms. structural class does not contain core but maintains capacity to covalently acylate its targets. Using TEM-1 enzyme, we characterized avibactam inhibition by measuring on-rate acylation and off-rate deacylation. The deacylation was 0.045 min −1 , which allowed investigation route from TEM-1. NMR MS, showed proceeds...
The heart of the H+ conductance mechanism in homotetrameric M2 channel from influenza A is a set four histidine side chains. Here, we show that protonation third these imidazoles coincides with acid activation this transmembrane and that, at physiological pH, closed by two imidazole-imidazolium dimers, each sharing low-barrier hydrogen bond. This unique construct succeeds distributing pair charges over rings many atoms low dielectric environment to minimize charge repulsion. These dimers...
The phase diagram of the ferromagnetic Kondo model for manganites was recently investigated using computational techniques by Yunoki et al. [Phys. Rev. Lett. 80, 845 (1998)]. In dimensions 1, 2, and $\ensuremath{\infty}$ classical localized spins, this study suggested a rich low-temperature with three dominant regions: (i) phase, (ii) separation between hole-undoped antiferromagnetic hole-rich domains, (iii) incommensurate spin correlations. purpose present paper is twofold: (a) First,...
We report on a Monte Carlo study of two-dimensional Ginzburg-Landau superconductors in magnetic field. find evidence suggestive first-order phase transition between low-temperature state characterized by power-law positional correlations the superfluid density and high-temperature vortex-fluid state. A key aspect our is introduction quantity proportional to Fourier transform which can be sampled efficiently Landau gauge simulations satisfies useful sum rule.
B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological cancers but high quality chemical probes are necessary to evaluate its therapeutic potential. Here we report potent BCL6 inhibitors that demonstrate cellular target engagement and exhibit exquisite selectivity based on mass spectrometry analyses following proteomic pull down. Importantly, proteolysis-targeting chimera (PROTAC) was also developed shown significantly degrade in number of diffuse large...
Infiltration of tumor-associated macrophages (TAM) characterized by an M2 phenotype is overriding feature in malignant tumors. Reprogramming TAM the most cutting-edge strategy for cancer therapy. In present study, iron-based metal-organic framework (MOF) nanoreactor loaded with dihydroartemisinin (DHA) developed, which provides high uptake and retains their viability, thus effectively addressing inefficiency DHA at low concentrations. Impressively, DHA@MIL-101 can selectively accumulate...
Inhibition of the protein–protein interaction between B-cell lymphoma 6 (BCL6) and corepressors has been implicated as a therapeutic target in diffuse large (DLBCL) cancers profiling potent selective BCL6 inhibitors are critical to test this hypothesis. We identified pyrazolo[1,5-a]pyrimidine series binders from fragment screen parallel with virtual screen. Using structure-based drug design, binding affinity was increased 100000-fold. This involved displacing crystallographic water, forming...
Lung cancer recruits tumor-associated macrophages (TAMs) massively, whose predominantly pro-tumor M2 phenotype leads to immunosuppression. Dihydroartemisinin (DHA) has been proven remodel TAM into an anti-tumor M1 at certain concentrations in the present study, which was hypothesized facilitate anti-lung immunotherapy. However, how DHA remodels not yet uncovered. Our previous work revealed that could trigger ferroptosis lung cells, may also be observed thereupon. Sequentially, current found...
Abstract Disconnections between in vitro responses and those observed whole cells confound many attempts to design drugs areas of serious medical need. A method based on 1D 1 H NMR spectroscopy is reported that affords the ability monitor hydrolytic decomposition carbapenem antibiotic meropenem inside Escherichia coli expressing New Delhi metallo‐β‐lactamase subclass (NDM‐1), an emerging antibiotic‐resistance threat. Cell‐based studies demonstrated two known NDM‐1 inhibitors, L ‐captopril...
Fatty acid biosynthesis is essential to bacterial growth in Gram-negative pathogens. Several small molecules identified through a combination of high-throughput and fragment screening were cocrystallized with FabH (β-ketoacyl-acyl carrier protein synthase III) from Escherichia coli Streptococcus pneumoniae. Structure-based drug design was used merge several scaffolds provide new class inhibitors. After optimization for enzyme inhibitory potency, compounds demonstrated antimicrobial activity...
Dihydroartemisinin (DHA), a natural product derived from the herbal medicine Artemisia annua, is recently used as novel anti-cancer agent. However, some intrinsic disadvantages limit its potential for clinical management of cancer patients, such poor water solubility and low bioavailability. Nowadays, nanoscale drug delivery system emerges hopeful platform improve treatment. Accordingly, metal-organic framework (MOF) based on zeolitic imidazolate framework-8 was designed synthesized to carry...
Abstract A low‐viscosity bio‐based carbamate acrylate was synthesized by the reaction of pentamethylene diisocyanate derived from pentanediamine with a low molecular weight hydroxyl ester. The used in 3D printing ceramics, and correlation between solid content viscosity ceramic slurry observed. exhibits good stability shrinkage. results indicate that 2.11 Pa s 80 wt%, which makes it suitable for digital light processing printing. In addition, new type photoinitiator called...
Candida albicans biofilms are resistant to several clinical antifungal agents. Thus, it is necessary develop new antibiofilm intervention measures. Pseudolaric acid A (PAA), a diterpenoid mainly derived from the pine bark of Pseudolarix kaempferi, has been reported have an inhibitory effect on C. albicans. The primary aim current study was investigate PAA when combined with fluconazole (FLC) and explore underlying mechanisms. Biofilm activity assessed by tetrazolium {XTT...
Solitary fibular metastasis from lung adenocarcinoma is exceedingly rare, with only five documented cases. This report presents a 40-year-old non-smoking Asian male who initially presented painful swelling in the right knee. Imaging revealed bony destruction of head, and further investigations chest CT, PET/C, pathologic biopsy genetic testing identified primary EGFR exon 19 deletion mutation. The patient was treated Osimertinib, resulting significant tumor reduction. followed by...
Abstract Exploring the promiscuity of native enzymes presents a promising strategy for expanding their synthetic applications, particularly catalyzing challenging reactions in non-native contexts. In this study, we explore promiscuous potential old yellow (OYEs) to facilitate Morita-Baylis-Hillman reaction (MBH reaction), leveraging substrate similarities between MBH and reduction reaction. Using mass spectrometry spectroscopic techniques, confirm Gk OYE both reactions. By blocking H - +...
Abstract Pazopanib (PAZ), an oral multi-tyrosine kinase inhibitor, demonstrates promising cytostatic activities against various human cancers. However, its clinical utility is limited by substantial side effects and therapeutic resistance. We developed a nanoplatform capable of delivering PAZ for enhanced anti-breast cancer therapy. Nanometer-sized PAZ@Fe-MOF, compared to free PAZ, demonstrated increased anti-tumor in both syngeneic murine 4T1 xenograft MDA-MB-231 breast models....