A5088069272- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Prostate Cancer Treatment and Research
- Viral Infectious Diseases and Gene Expression in Insects
- Trypanosoma species research and implications
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Mass Spectrometry Techniques and Applications
- Cancer Cells and Metastasis
- Research on Leishmaniasis Studies
- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Mechanisms and Therapy
- Veterinary Equine Medical Research
- Cytomegalovirus and herpesvirus research
- Pneumonia and Respiratory Infections
- Caveolin-1 and cellular processes
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer-related gene regulation
- Neonatal Respiratory Health Research
- Axon Guidance and Neuronal Signaling
Friedrich-Alexander-Universität Erlangen-Nürnberg
2024-2025
Universitätsmedizin Göttingen
2024
University of Veterinary Medicine Hannover, Foundation
2010-2014
University of Veterinary Medicine Vienna
2011-2014
Bernhard Nocht Institute for Tropical Medicine
2013
Charité - Universitätsmedizin Berlin
2009
University of Freiburg
2004-2007
Christ University
2006
University Medical Center Freiburg
2005-2006
World Health Organization
1997
We treated 10 children with X-linked SCID (SCID-X1) using gammaretrovirus-mediated gene transfer. Those sufficient follow-up were found to have recovered substantial immunity in the absence of any serious adverse events up 5 years after treatment. To determine influence vector integration on lymphoid reconstitution, we compared retroviral sites (RISs) from peripheral blood CD3+ T lymphocytes patients taken between 9 and 30 months transplantation transduced CD34+ progenitor cells derived 1...
Protozoa of the Leishmania genus cause a variety disease forms that rank at top list neglected tropical diseases. Anti-leishmanial drugs based on pentavalent antimony have been mainstay therapy for over 60 years and resistance against them is increasingly encountered in field. The biochemical basis this poorly understood likely diverse. No stringent correlation between genetic markers has so far shown, prompting us to use functional cloning approach identify resistance. Using gene libraries...
Abstract Malignant melanoma, the most aggressive form of skin cancer, is often incurable once metastatic dissemination cancer cells to distant organs has occurred. We investigated role Transcription Factor Activating Enhancer-Binding Protein 2ε (AP2ε) in progression melanoma. Here, we observed that AP2ε a potent activator metastasis and newly revealed be an important player melanoma plasticity. High levels lead worsened prognosis patients. Using transgenic mouse model with specific loss...
Around 180 genes have been associated with congenital anomalies of the kidney and urinary tract (CAKUT) in mice, represent promising novel candidate for human CAKUT. In whole-exome sequencing data two siblings genetically unresolved multicystic dysplastic kidneys (MCDK), prioritizing variants murine CAKUT-associated yielded a rare variant teashirt zinc finger homeobox 3 (TSHZ3) gene. Therefore, role TSHZ3 CAKUT was assessed. Twelve patients from 9/301 (3%) families carried five different...
Prostate-specific membrane antigen (PSMA) is a type-II glycoprotein that was initially identified in LNCaP cells. It expressed at elevated levels prostate cancer. In view of the correlation between expression PSMA and disease grade stage, considered to be one most promising biomarkers diagnosis treatment cells undergoes internalization via clathrin-coated pits followed by accumulation endosomes. associates with different types detergent-resistant membranes (DRMs) along secretory pathway. Its...
Abstract BACKGROUND Prostate‐specific membrane antigen (PSMA) is a promising biomarker in the diagnosis of prostate cancer and potential target for antibody‐based therapeutic strategies. We isolated canine PSMA cDNA investigated cellular biochemical characteristics recombinant protein as animal preclinical studies antibody based‐therapies. METHODS Canine was by PCR, cloned into expression vectors transfected COS‐1 MDCK cells. The biosynthesis glycosylation were pulse‐chase experiments,...
COVID-19 vaccination has been a critical tool in the global fight against pandemic, offering hope for return to normalcy. While immediate side effects of are well-documented and generally mild, concerns around potential long-term complications have emerged. This article explores reported following COVID vaccination, factors influencing these outcomes, strategies managing addressing them. By delving into research findings recommendations, we aim provide valuable insights individuals...
Prostate‐specific membrane antigen (PSMA) is a surface protein overexpressed in prostate cancer and neovasculature of further tumours. It therefore one the most promising biomarkers diagnosis treatment cancer. PSMA associated with detergent‐resistant membranes (DRMs). The mature form mainly insoluble Lubrol WX, but does not associate Triton X‐100 DRMs. Recently we could demonstrate that cross‐linking cell specific antibodies activates different signalling cascades like MAPK‐pathway. Here...
Previous observations of retroviral vector induced oncogenesis in preclinical models and a clinical SCID-X1 gene therapy study have prompted large-scale integration site analysis. In vitro vivo studies indicate that lentiviral vectors may lower the risk insertional mutagenesis compared to common vectors. Several could show distribution is dependent (MLV, HIV, SIV, ASLV) type LTR play crucial role. Here, we analyzed possible influence distinct internal promoters transgenes on clone survival....
Retrovirus gene transfer into hematopoietic stem cells is an effective treatment of X-linked severe combined immunodeficiency (SCID-X1). Nevertheless, the recent occurrence T ALL like disease in three SCID-X1 patients led to intensive studies on vector biosafety with focus insertional mutagenesis. Large-scale mapping retrovirus integration sites human cell lines revealed preferential genomic coding regions, particular near transcription start sites. We hypothesized that clinical...