A5018746277- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Gene Regulatory Network Analysis
- Muscle Physiology and Disorders
- Genetics and Physical Performance
- Muscle metabolism and nutrition
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Mesenchymal stem cell research
- RNA modifications and cancer
- Liver Disease and Transplantation
- Neurobiology and Insect Physiology Research
- Cancer-related molecular mechanisms research
- Liver Diseases and Immunity
- Spacecraft and Cryogenic Technologies
- Single-cell and spatial transcriptomics
- Circular RNAs in diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Spacecraft Design and Technology
- Peroxisome Proliferator-Activated Receptors
- Protein Degradation and Inhibitors
- Genetics, Bioinformatics, and Biomedical Research
Novo Nordisk (Denmark)
2022-2024
University of Liverpool
2014-2021
Hudson Institute
2021
University of Hull
2021
Rogers (United States)
2021
Oregon State University
2021
John Wiley & Sons (United Kingdom)
2021
University of Copenhagen
2010-2017
Rigshospitalet
2017
Novo Nordisk Foundation
2017
MicroRNAs (miRNA), small noncoding RNA molecules, may regulate protein synthesis, while resistance exercise training (RT) is an efficient strategy for stimulating muscle synthesis in vivo. However, RT increases mass, with a very wide range of effectiveness humans. We therefore determined the expression level 21 abundant miRNAs to determine whether variation these was able explain RT-induced gains mass. Vastus lateralis biopsies were obtained from top and bottom ∼20% responders 56 young men...
Abstract Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated is unknown. Here we show that reduction mice heterozygous for eIF6 results normal but less blood cholesterol triglycerides. controls fatty acid synthesis glycolysis a cell autonomous fashion. acts by exerting translational control adipogenic transcription factors like...
Obesity is central in the development of insulin resistance. However, underlying mechanisms still need elucidation. Dysregulated microRNAs (miRNAs; post-transcriptional regulators) adipose tissue may present an important link.The miRNA expression subcutaneous from 19 individuals with severe obesity (10 women and 9 men) before after a 15-week weight loss intervention was studied using genome-wide microarray analysis. The results were validated RT-qPCR, pathway enrichment analysis silico...
MicroRNAs (miRNAs) are increasingly recognized as fine-tuning regulators of metabolism, and dysregulated in several disease conditions. With their capacity to rapidly change gene expression, miRNAs also important development cell differentiation. In the current study, we describe an impaired myogenic muscle stem cells isolated from humans with type 2 diabetes (T2DM) assess whether this phenotype is regulated by miRNAs. We measured global miRNA expression during vitro differentiation derived...
Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding molecular networks underlying this phenomenon is crucial. Here, by exploiting power computational modeling, we show that induces profound changes in gene regulatory linking signaling selective control translation to energy metabolism tissue remodeling. We discovered knockdown mTOR-independent factor Eif6, which predicted be a key regulator process, affects mitochondrial...
A relatively large percentage of patients with chronic obstructive pulmonary disease (COPD) develop systemic co-morbidities that affect prognosis, among which muscle wasting is particularly debilitating. Despite significant research effort, the pathophysiology this important extrapulmonary manifestation still unclear. key question remains unanswered to what extent inflammatory mediators might play a role in pathology. Cigarette smoke (CS) main risk factor for developing COPD and therefore...
Aim We performed genome-wide and transcriptome-wide profiling to identify genes single nucleotide polymorphisms (SNPs) associated with the response of triglycerides (TG) exercise training. Methods Plasma TG levels were measured before after a 20-week endurance training programme in 478 white participants from HERITAGE Family Study. Illumina HumanCNV370-Quad v3.0 BeadChips genotyped using BeadStation 500GX platform. Affymetrix HG-U133+2 arrays used quantitate gene expression baseline muscle...
Abstract Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity. The genetic and molecular mechanisms underlying this phenomenon are currently not understood. By investigating genome-wide variants associated with baseline exercise-induced changes (∆) sensitivity index (S i ) healthy volunteers, we have identified novel candidate genes whose mouse knockouts phenotypes were consistent a...