A5082328859- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Sarcoma Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Sexual function and dysfunction studies
- Congenital Heart Disease Studies
- Immune Cell Function and Interaction
- Cardiovascular Function and Risk Factors
- Cardiac and Coronary Surgery Techniques
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Cardiac Arrhythmias and Treatments
- Urologic and reproductive health conditions
- Vascular Malformations and Hemangiomas
- Musculoskeletal synovial abnormalities and treatments
- Renal and Vascular Pathologies
- Ultrasound in Clinical Applications
- Metastasis and carcinoma case studies
- Immunodeficiency and Autoimmune Disorders
- Stress Responses and Cortisol
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Cardiac tumors and thrombi
Sichuan University
2015-2025
West China Hospital of Sichuan University
2015-2025
Nanchang University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Abstract Background Previous studies have shown that preoperative co-existing moderate/severe mitral regurgitation (MR) and postoperative persistent MR can affect the prognosis of patients with transcatheter aortic valve replacement (TAVR). However, most only focus on leaflets annulus, few touches papillary muscle. Purpose To explore relationship between shape, position deformation muscles outcome after TAVR. Methods This retrospective cohort study included 1159 consecutive who underwent...
Abstract Erectile dysfunction (ED) is a male sexual with gradually increasing prevalence, and current treatments are ineffective. This study aims to find safer more effective treatment for erectile dysfunction. Bone marrow-derived mesenchymal stem cells (BM-MSCs) treated VEGFA. The expression of endothelial markers vWF, VE-cadherin eNOS were determined by overexpressing MALAT1 CDC42, respectively. results showed that interference CDC42 inhibited the differentiation BM-MSCs ECs marker-related...
Abstract Background Erectile dysfunction (ED) is a common male sexual dysfunction, with an increasing incidence, and the current treatment often ineffective. Methods Vascular endothelial growth factor (VEGFA) was used to treat bone marrow-derived mesenchymal stem cells (BM-MSCs), their cell migration rates were determined by Transwell assays. The expression of von Willebrand Factor (vWF)VE-cadherin, nitric oxide synthase(eNOS) markers qRT‒PCR Western blot analyses. MALAT1-induced...
Intravesical chemotherapy and immunotherapy are common adjuvant treatments for non-muscle invasive bladder cancer post-surgery. Analyzing adverse events linked to these therapies, can assist in clinical decision-making risk assessment.
Objective: To investigate the clinicopathological features, immunophenotypes and molecular genetics of fibroma tendon sheath (FTS). Methods: One hundred thirty-four cases FTS or tenosynovial diagnosed in Department Pathology, West China Hospital, Sichuan University, Chengdu, from January 2008 to April 2019 were selected. The clinical histologic features these retrospectively reviewed. Immunohistochemistry, fluorescence situ hybridization (FISH) reverse transcription-polymerase chain reaction...
A prospective, single-center, single-arm, and open-design study was performed to evaluate the feasibility safety of transseptal transcatheter mitral valve replacement in treatment severe regurgitation. Patients with symptomatic moderate-severe or regurgitation at high-surgical risk anatomically appropriate for HighLife (TSMVR) system West China Hospital, Sichuan University from December 2021 August 2022 were enrolled. Four patients (1 male 3 females) included, a median age 68.5 (64.0-77.0)...
Objectives: To evaluate the feasibility and preliminary clinical results of transcatheter pulmonary valve replacement (TPVR) with domestically-produced balloon-expandable Prizvalve system. Methods: This is a prospective single-center observational study. Patients postoperative right ventricular outflow tract (RVOT) dysfunction, who were admitted to West China Hospital Sichuan University from September 2021 March 2023 deemed anatomically suitable for TPVR valve, included. Clinical, imaging,...
Objective: To evaluate the safety and efficacy of transcatheter aortic valve implantation (TAVI) with novel Prizvalve® system in treating severe stenosis. Methods: This is a single-center, prospective, single-arm, observational study. A total 11 patients stenosis high risk or inappropriate for conventional surgical replacement (SAVR) were included, TAVI was achieved between March 2021 May West China Hospital. Transthoracic echocardiography (TTE) performed immediately after prosthesis to mean...
Objective: To investigate the feasibility and value of interphase fluorescence in situ hybridization (FISH) pathological diagnosis, differential diagnosis therapeutic assessment B-cell lymphomas. Methods: The cohort included 604 cases lymphoma which were collected at West China Hospital from May 2010 to December 2016.And all subjected FISH using 11 break apart or fusion probes (MYC, bcl-2, bcl-6, IRF4, MYC/IgH, bcl-2/IgH, CCND1/IgH, IgH, API2/MALT1, p53/ATM, D13S319/CEP12). Results: median...
Background: Information related to the optimal assessment and calculation method for bicuspid aortic valve (BAV) annulus diameter by computed tomography (CT) is limited.Given that pronounced oval-shaped of BAV prone reshape deform after implantation.Purpose: To clarify measurements patients with preferred TAVR, our study compared intraoperative sizing five different approaches transthoracic echocardiography (TTE), 3-dimensional transesophageal (3DTEE) CT.Methods: We enrolled 104 BAVs...
Objective: To investigate the value of MDM2 RNA in situ hybridization (RNA-ISH) diagnosing atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) and dedifferentiated (DDL). Methods: A total 26 ALT/WDL/DDLs diagnosed from March 2017 to May 2019 West China Hospital, Sichuan University, Chengdu, 18 control cases were included. RNA-ISH was performed on all samples compared with fluorescence (FISH) immunohistochemistry (IHC) regarding their performance detecting MDM2. Results: All...
多国心脏介入与心脏外科专家联合起草了首份经导管主动脉瓣置换术治疗二叶式主动脉瓣狭窄国际专家共识。在系统综述近年最新证据的基础上，该共识采用德尔菲法对15个核心问题征集了专家组意见，在解剖分型、治疗方式选择、术前计划、人工瓣膜选择、术中操作、术后管理等诊治全流程上进行了操作推荐并点明了相应证据缺失。该文对该共识的方法学及推荐要点做简要介绍。.
Objective: To investigate the clinicopathological and cytogenetic features of cryptic COL1A1-PDGFB fusion dermatofibrosarcoma protuberans (CC-DFSP). Methods: Three cases CC-DFSP diagnosed in West China Hospital, Sichuan University, Chengdu, from January 2021 to September were studied. Immunohistochemistry for CD34 other markers, fluorescence situ hybridization (FISH) PDGFB, COL1A1, next-generation sequencing (NGS), reverse-transcriptase polymerase chain reaction (RT-PCR) Sanger performed....
近年来，结构性心脏病的介入治疗发展迅猛，其范围不仅限于先天性心脏病、瓣膜性心脏病，还包括多项新兴的介入治疗技术，如左心耳封堵术、经皮心肌内室间隔射频消融术、心力衰竭的器械治疗等。我国结构性心脏病介入治疗的起步相对较晚，但随着国内相关行业专家的共同努力，近年来发展迅猛，在器械研发、技术创新等方面都取得了不少成果，部分由我国自主研发的器械和技术已经逐步走向国际。在《中华心血管病杂志》创刊50周年之际，该文通过梳理国内外相关的重磅研究和重要事件，以先天性心脏病和心脏瓣膜病的介入治疗为例，展示结构性心脏病介入治疗的主要发展历程及其最新进展。.
Objective:To evaluate the feasibility of immediate reconstruction facial nerve defect by using cable grafting greater auricular after parotid cancer resection.Method:Clinical data 11 patients suffering from was reviewed.9 cases were diagnosed as mucoepidermoid carcinoma and 2 adenoid cystic carcinoma. Total parotidectomy elective neck dissection performed before interposed between stumps trunk its branches. The electromyogram symmetry mimetic musculature evaluated. House Brackmann (HB)...
近年来，心脏瓣膜病的介入治疗发展迅猛，各瓣膜领域的循证医学证据逐步积累、器械研发不断推陈出新。我国瓣膜病介入治疗开展相对较晚，但现开展瓣膜病介入治疗的中心和团队快速增多，对各瓣膜领域的研究热点、当前应用与将要面临的困难及挑战应有足够的认识。该文主要总结了2021年主动脉瓣、二尖瓣、三尖瓣、肺动脉瓣4个领域国外发展的新形势及我国的应用现状。.