A5114020362- Nanopore and Nanochannel Transport Studies
- CAR-T cell therapy research
- Cancer Research and Treatments
- Mesenchymal stem cell research
- Lung Cancer Treatments and Mutations
- Chromosomal and Genetic Variations
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA regulation and disease
- Mycobacterium research and diagnosis
- interferon and immune responses
- Microfluidic and Capillary Electrophoresis Applications
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Microfluidic and Bio-sensing Technologies
- Lung Cancer Research Studies
- RNA Interference and Gene Delivery
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Phagocytosis and Immune Regulation
- Viral-associated cancers and disorders
- T-cell and B-cell Immunology
Fujian Normal University
2021-2025
Fujian Institute of Microbiology
2021
Chinese Academy of Sciences
2007-2014
Institute of Zoology
2014
Hebei University
2014
Institute of Biophysics
2014
State Key Laboratory of Transducer Technology
2007
Institute of Electronics
2007
piRNAs are a class of small RNAs that is most abundantly expressed in the animal germ line. Presently, substantial research going on to reveal functions epigenetic and post-transcriptional regulation transposons genes. A piRNA database for collection, annotation structuring these data will be valuable contribution field, we have therefore developed piRBase platform which integrates various piRNA-related high-throughput data. has largest collection among existing databases, contains at...
Objective: Combining immune checkpoint inhibitors and antiangiogenic agents offers a promising strategy to counteract the cooperative promotion of solid tumor growth by checkpoints intratumoral angiogenesis. Methods: We investigated potential thalidomide (THD) anti-PD-1 antibody (PD-1 mAb) in suppressing growth, enhancing immunity, inhibiting Results: THD exhibited regulatory effects on PD-1 CD4+ T cells PD-L1 cancer cells, along with inhibition A549 Lewis lung carcinoma (LLC) cell lines....
Abstract CD30 is a member of the tumor necrosis factor receptor (TNFR) superfamily and expressed in both normal malignant lymphoid cells. However, role lymphopoiesis not known. In this study, we showed was T B cells, but its deficiency mice had no effect on T‐ B‐cell development. fact, attenuated response to T‐cell‐dependent antigens. The impaired cell CD30‐deficient caused by reduction activation‐induced cytidine deaminase (AID) expression. Moreover, exhibited decreased TCR‐mediated...
Abstract The TREX1 gene encodes a highly efficient DNA exonuclease that plays an important role in maintaining homeostasis the cytoplasm. mutations lead to spectrum of type I interferonopathies are characterized by systemic inflammation, high blood levels autoantibodies, and spontaneously activated immunity. TREX1‐P212fs mutation is thought be linked lupus erythematosus (SLE). Here, we analyzed functions 20 mutants found mutant was able reduce enzyme activity missed endoplasmic reticulum...
Targeted therapies hold promise for efficiently and accurately delivering cytotoxic drugs directly to tumor tissue exert anticancer effects. CD47 is a membrane protein expressed in variety of malignant tumors hematopoietic cells, which plays key role immune escape progression. Although immunocheckpoint therapy has been developed recent years, many patients cannot benefit from it because its low efficiency. To strengthen extend the therapeutic efficacy anti-CD47 monoclonal antibody (mAb), we...
Abstract The paraspeckle protein NONO is a multifunctional nuclear participating in the regulation of transcriptional regulation, mRNA splicing and DNA repair. However, whether plays role lymphopoiesis not known. In this study, we generated mice with global deletion bone marrow (BM) chimeric which deleted all mature B cells. We found that did affect T‐cell development but impaired early B‐cell BM at pro‐ to pre‐B‐cell transition stage maturation spleen. Studies demonstrated NONO‐deficient...
B-cell development undergoes a series of steps from the bone marrow to secondary lymphoid organs. A defect in can lead immunodeficiency or malignant disorders, such as leukaemia lymphoma. Long non-coding RNAs have been reported act important regulators many pathological processes. However, very little is known regarding role lncRNAs during and regulation their expression. In this study, we explored expression lncRNA Gme00492 development. We observed that lnc00492 was highly expressed...