A5107909576- Acute Myeloid Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- RNA Interference and Gene Delivery
- Platelet Disorders and Treatments
- MRI in cancer diagnosis
- Lymphoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Building Energy and Comfort Optimization
- Advanced X-ray and CT Imaging
- Hematopoietic Stem Cell Transplantation
- Renal and related cancers
- Nanoparticle-Based Drug Delivery
- Tuberous Sclerosis Complex Research
- Graphene and Nanomaterials Applications
- Thyroid and Parathyroid Surgery
- Intraperitoneal and Appendiceal Malignancies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Energy, Environment, Economic Growth
- Blood disorders and treatments
Fudan University
2024-2025
Zhongshan Hospital of Xiamen University
2024-2025
Agricultural Genomics Institute at Shenzhen
2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Peking University
2024
Southwest University of Science and Technology
2024
Zhongshan Hospital
2024
First Affiliated Hospital of Fujian Medical University
2023
Fujian Medical University
2023
Abstract Purpose: Early detection and intervention can decrease the mortality of breast cancer significantly. Assessments genetic/genomic variants in circulating tumor DNA (ctDNA) have generated great enthusiasm for their potential application as clinically actionable biomarkers management early-stage cancer. Experimental Design: In this study, 861 serial plasma matched tissue specimens from 102 patients with who need chemotherapy 50 individuals benign tumors were deeply sequenced via...
Erythropoietin is known as the requisite cytokine for red blood cell production. Its receptor, expressed at a high level on erythroid progenitor/precursor cells, also found endothelial, neural, and other types. erythropoietin receptor expression in developing adult brain suggest their possible involvement neurodevelopment neuroprotection. During ischemic stress, erythropoietin, which hypoxia inducible, can contribute to homeostasis by increasing production increase oxygen carrying capacity,...
Tandem repeats (TRs) are genomic regions that tandemly change in repeat number, which often multiallelic. Their characteristics and contributions to gene expression quantitative traits rice largely unknown. Here, we survey TR variations based on 231 genome assemblies the pan-genome graph. We identify 227,391 multiallelic loci, including 54,416 absent from Nipponbare reference genome. Only 1/3 show strong linkage with nearby bi-allelic variants (SNPs, Indels PAVs). Using 193 panicle 202 leaf...
MicroRNAs (miRNAs) play a pivotal role in carcinogenesis. Dysregulation of miRNAs, both oncogenic miRNAs and tumour-suppressive is closely associated with cancer development progression. The levels could be changed epigenetically by DNA methylation the 5' untranslated region (UTR) pre-mature miRNAs. To investigate whether alters expression miR-129 lung cancer, we did assays found that UTR miR-129-2 gene was absolutely methylated A549 SPCA-1 cells, but totally un-methylated 95-D cells....
Abstract Objectives This study aimed to assess the predictive value of radiomics derived from intratumoral and peritumoral regions develop a nomogram predict preoperative nuclear grade overall survival (OS) in patients with clear cell renal carcinoma (ccRCC). Methods The included 395 ccRCC our institution. Center A (anonymous) institution were randomly divided into training cohort ( n = 284) an internal validation 71). An external comprising 40 B also was included. Computed tomography (CT)...
Introduction The rice improvement process, driven by modern breeding techniques, represents the second revolutionary advancement in agronomic traits, following domestication. Advances pan-genomes and enhanced capacity for analyzing structural variations have increasingly highlighted their role genetic improvement. Transposable element (TE) variants been previously reported to influence genomic diversity during domestication, but contribution from landraces improved varieties remains unclear....
Genotyping epidermal growth factor receptor (
Background Eltrombopag (EPAG), an oral thrombopoietin receptor agonist (TPO-RA), has been proven to improve the hematologic response without increasing toxic effects as a first-line therapy combined with standard immunosuppressive treatment (IST) in adults severe aplastic anemia (SAA). Nevertheless, clinical evidence on efficacy of EPAG children acquired is limited and controversial. Methods We performed single-center, retrospective study analyze outcomes fifteen patients aged ≤18 years...
Abstract MYB plays vital roles in regulating proliferation and differentiation of hematopoietic progenitor cells, dysregulation has been implicated the pathogenesis leukemia. Although transcription well studied, its detailed underlying regulatory mechanisms still remain elusive. Here, we detected long-range interaction between upstream regions, −34k −88k, promoter K562, U937, HL-60 cells using circularized chromosome conformation capture (4C) assay, which declined when was downregulated...
The optimal approach to assess the postoperative status of lymph nodes in differentiated thyroid cancer (DTC) remains controversial. Our aim was determine if log odds negative nodes/T stage ratio (LONT) could serve as a new prognostic and predictive tool for DTC without metastases patients aged ≥ 55 years.The Surveillance, Epidemiology, End Results (SEER) database used study role LONT ≥55 years diagnosed with metastases. primary outcome overall survival (OS). Kaplan-Meier method Cox...
Human pluripotent stem cells (hPSCs) hold great promise for applications in regenerative medicine and disease modeling. Here, we present a protocol establishing edited hPSC cell lines utilizing visualized orthogonal selective reporters. We describe steps constructing plasmids, carrying out culture electroporation, as well performing drug-fluorescent dual enrichment, clone screening, line characterization. This facilitates the achievement of single-base homozygous mutations reporter knockins,...
Relapsed and refractory acute myeloid leukemia (RR-AML) still poses major treatment concerns. Current treatments include high doses of cytarabine or fludarabine in combination with G-CSF (FLAG), but provide mixed results. Low-dose decitabine, a hypomethylating drug, aclarubicin (DAC) has shown safety efficacy the AML; however, clinical data are limited for RR-AML.In this study, we retrospectively compared response DAC vs FLAG RR-AML patients.For 35 patients enrolled overall rates reached...
This paper provides the first evidence of debt and stock market reaction to corporate green bond issuance in simultaneously largest developing economy emerging market, China. Utilizing a most comprehensive sample Chinese bonds, we document pricing premium bonds relative conventional bonds. The economic magnitude is greatly larger than that an international documented prior studies. pronounced for new issues from high social responsibility (CSR) issuers underwriters. It also stronger with...
The c-Myb transcription factor is a major regulator that controls differentiation and proliferation of hematopoietic progenitor cells, which frequently deregulated in hematological diseases, such as lymphoma leukemia. Understanding the mechanisms regulating c-myb gene challenging it lacks typical promoter multiple factors are involved. Our previous studies identified some distal regulatory elements upstream regions murine myeloid M1 but detailed still remain unclear. In present study, we...
Immune thrombocytopenia is the most common autoimmune disorder involving blood types. In several studies, role of T CD4+ cells in patients with immune has been associated different results. Therefore, this study, aim applied research pathogenesis thrombocytopenia, relationship was investigated between number cells, serum levels IL-11 and IL-17 cytokines, platelet count. regard, 100 healthy individuals were included study. The cell counts examined by flow cytometry addition, interleukins 11...