Background: Current diagnosis of heart failure with preserved ejection fraction (HFpEF) is suboptimal. We tested the hypothesis that comprehensive machine learning (ML) left ventricular function at rest and exercise objectively captures differences between HFpEF healthy subjects. Methods Results: One hundred fifty-six subjects aged >60 years (72 HFpEF+33 for initial analyses; 24 hypertensive+27 breathless independent evaluation) underwent stress echocardiography, in MEDIA study (Metabolic...

Abstract: COPD is accompanied by limited physical activity, worse quality of life, and increased prevalence depression. A possible link between depression may be irisin, a myokine, expression which in the skeletal muscle brain positively correlates with activity. Irisin enhances synthesis brain-derived neurotrophic factor (BDNF), neurotrophin involved reward-related processes. Thus, we hypothesized that mood disturbances accompanying are reflected changes irisin–BDNF axis. Case history,...

Abstract Aims Echocardiographic predictors of outcomes in heart failure with preserved ejection fraction (HFpEF) have not been systematically or independently validated. We aimed at identifying echocardiographic cardiovascular events a large cohort patients HFpEF and to validate these an independent cohort. Methods results assessed the association between parameters 515 left ventricular (LV) (>50%) MEtabolic Road DIAstolic Heart Failure (MEDIA) multicentre study. validated out findings...

Background: Both systolic and diastolic tissue Doppler (TD) velocities have an important diagnostic prognostic role in cardiology. We aimed to compare TD between two different echocardiography systems. Patients: Thirty‐one consecutive patients (mean age: 65.2 ± 17.5 years; 12 males) were enrolled. Methods: Systolic (Sa), early (Ea), late (Aa) measured by at the lateral mitral annulus a Sonos 2000 (Hewlett‐Packard, Andover, MA, USA) Philips iE33 system. The E/Ea ratio was calculated. Results:...

As atrial stiffness (Kla) is an important determinant of cardiac pump function, better mechanical characterization left (LA) cavity would be clinically relevant. Pulmonary venous ablation option for fibrillation (AF) treatment that offers a powerful context improving our understanding LA function. We hypothesized relation could detected between invasive estimation Kla and new non-invasive deformation parameters traditional ventricular (LV) function descriptors, so can estimated...

The term receptor reserve, first introduced and used in the traditional theory, is an integrative measure of response-inducing ability interaction between agonist a system (consisting its downstream signaling). underlying phenomenon, i.e., stimulation submaximal fraction receptors can apparently elicit maximal effect (in certain cases), provides opportunity to assess reserve. However, determining reserve challenging for agonists with short half-lives, such as adenosine. Although adenosine...

Radiofrequency catheter ablation of atrial fibrillation (AF) has been proved to be effective and prevent progressive left (LA) remodeling. Cryoballoon (CCA), using a different energy source, was developed simplify the procedure. Our hypothesis that successful CCA can also LA 36 patients selected for their first because nonvalvular paroxysmal AF had echocardiography before 3, 6 12 months after CCA. diameters, volumes (LAV) volume index (LAVI) were evaluated. function assessed by: early...

The term "diseasome of physical inactivity" was coined by Pedersen to explain clustering chronic diseases linked inactivity. Accordingly, inactivity per se contributes the accumulation visceral fat, which, generates low-grade systemic inflammation, emergence chronic, non-communicable (type 2 diabetes, cardiovascular diseases, colon cancer, postmenopausal breast dementia, depression). Diversity these disorders posits possible involvement a supraphysiological system. circadian system is...

The A1 adenosine and M2 muscarinic receptors exert protective (including energy consumption limiting) effects in the heart. We investigated influence of deaminase (ADA) inhibition on a representative limiting function, direct negative inotropic effect elicited by adenosinergic muscarinergic systems, eu- hyperthyroid atria. Furthermore, we compared change interstitial level caused ADA nucleoside transport blockade, two well-established processes to stimulate cell surface receptors, both...

Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects. The aim this study was explore effect that CBD exerts on adenosinergic system paced left atria isolated from obese type Zucker Diabetic Fatty (ZDF) rats, maintained diabetogenic rat chow, received 60 mg/kg/day or vehicle via gavage for 4 weeks. We found N6-cyclopentyladenosine (CPA), relatively stable and poorly...

Based on in silico results, recently we have assumed that FSCPX, an irreversible A₁ adenosine receptor antagonist, inhibits the action of NBTI is apparent E/c curves agonists. As a mechanism for this unexpected effect, hypothesized FSCPX might modify equilibrative and NBTI-sensitive nucleoside transporter (ENT1) way allows ENT1 to transport but impedes inhibit transport. This assumption implies our method developed estimate reserve agonists with short half-life such as adenosine, its...

Cardiovascular morbidity and mortality carry great socioeconomic burden worldwide that mandates the development of new, efficacious therapeutic agents with limited adverse effects. O-(3-piperidino-2-hydroxy-1-propyl) nicotinic acid amidoxime (BGP-15) is a known, well-tolerable drug candidate exerts beneficial effects in several disease models. As BGP-15 has significant structural similarity propranolol, it arose might also have direct effect on heart. Thus, present work, we investigated...

In earlier studies, we generated concentration-response (E/c) curves with CPA (N6-cyclopentyladenosine; a selective A1 adenosine receptor agonist) or adenosine, in the presence absence of S-(2-hydroxy-5-nitrobenzyl)-6-thioinosine (NBTI, nucleoside transport inhibitor), and without pretreatment 8-cyclopentyl-N3-[3-(4-(fluorosulfonyl)-benzoyloxy)propyl]-N1-propylxanthine (FSCPX, chemical known as selective, irreversible antagonist), isolated, paced guinea pig left atria. Meanwhile, observed...

The receptorial responsiveness method (RRM) is a procedure that based on simple nonlinear regression while using model with two variables (X, Y) and (at least) one parameter to be determined (cx). of RRM describes the co-action agonists consume same response capacity (due use postreceptorial signaling in biological system). While RRM, uniquely, an acute increase concentration agonist (near receptors) can quantified (as cx), via evaluating E/c curves were constructed or another system. As...

The receptorial responsiveness method (RRM) enables the estimation of a change in concentration an (even degradable) agonist, near its receptor, via curve fitting to (at least) two concentration-effect (E/c) curves stable agonist. One should be generated before this change, and other afterwards, same system. It follows that RRM yields surrogate parameter (“c x ”) as agonist being equieffective with However, regression can conducted several ways, which affect accuracy, precision ease-of-use....

The danger of polypharmacy (polypragmasia) lies in the fact that it usually affects older people who suffer from several chronic diseases and are also less likely to medication adherence. For this reason, is important follow drug therapy these patients pharmacies, where feedback general practitioners specialists can take place event a problem. development pharmaceutical care crucial. In case patients, inadequate greatly increases adverse effects thus may increase mortality morbidity...

Abstract Background Albeit smoking cessation has unequivocal health benefits, attempts to quit are not unanimous, even in patient populations at high risk for smoking-related diseases cessation. Allelic variations of enzymes involved dopamine metabolism being considered as candidates nicotine addiction. We set out assess whether rs4680 G/A and rs2235186 polymorphisms COMT MAO-A, respectively associated with the ability chronic inflammatory pulmonary disease patients. Methods Patients managed...

Hypoxanthine-tricyclano is a synthetic adenosine analogue, in which adenine and ribose have been replaced by hypoxanthine morpholino-derived tricyclic moiety, respectively. We investigated whether hypoxanthine-tricyclano could influence atrial inotropy and/or chronotropy, two important functions regulated the A1 receptor, main receptor type of supraventricular myocardium. Paced left atria spontaneously beating right atria, isolated from male, 30-35 weeks old, Wistar rats, were used. The ino-...