A5033975646- Phytochemicals and Antioxidant Activities
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Antioxidant Activity and Oxidative Stress
- Regulation of Appetite and Obesity
- Adenosine and Purinergic Signaling
- Sirtuins and Resveratrol in Medicine
- Biochemical Analysis and Sensing Techniques
- Cardiac electrophysiology and arrhythmias
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Nitric Oxide and Endothelin Effects
- Complementary and Alternative Medicine Studies
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Natural Antidiabetic Agents Studies
- Cardiomyopathy and Myosin Studies
- Herbal Medicine Research Studies
- bioluminescence and chemiluminescence research
- Flavonoids in Medical Research
- Cancer Cells and Metastasis
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Issues in Pregnancy
- Heme Oxygenase-1 and Carbon Monoxide
- Phytochemical Studies and Bioactivities
University of Debrecen
2015-2025
Zrínyi Miklós National Defence University
2020
University of Oradea
2019
Eötvös Loránd University
1969
Male C57BL/6J mice were used to determine the possible therapeutic effects of our previously described tart cherry extract in a chronic obesity mouse model on metabolic parameters, glucose tolerance, inflammatory mediators, and antioxidant capacity. The control group received standard chow, high fat was switched diet tap water supplemented with 5% sucrose. + anthocyanin sucrose diet, but anthocyanin-rich dissolved their drinking water. After six weeks, an oral tolerance test performed,...
Active screening for resistant multidrug strain carriers remains an important component of infection control policy in any healthcare setting indifferent financial and logistical costs. The objective our study was to determine the spectrum bacterial colonization individually among intensive care unit patients. A retrospective observational performed Intensive Care Unit Emergency Clinical County Hospital Oradea during 2017. Medical records patients were used evaluation source ICU admission,...
Capsella bursa-pastoris Medik. (CBP) is a species with antibacterial, anti-inflammatory, antioxidant, anticancer, and hepatoprotective effects. We have chosen to study this because, although it common plant distinctive fruit appearance, its effects are not fully understood. The aim of was characterize the histoanatomy vegetative, reproductive organs CBP extracts in terms bioactive compounds antioxidant capacity. This investigated quantitative chemical composition using HPLC method, revealing...
Fenugreek is known since ancient times as a traditional herbal medicine of its multiple beneficial effects. Fenugreek’s most studied and employed effect hypoglycemic property, but it can also be useful for the treatment certain thyroid disorders or anorexia. The regulation glucose homeostasis complex mechanism, dependent on interaction different types hormones neurotransmitters other compounds. For study how diosgenin fenugreek seeds modify insulin sensitivity, we used rat resistance model...
BACKGROUND: Equisetum arvense L., commonly known as field horsetail is a perennial fern of which extracts are rich sources phenolic compounds, flavonoids, and acids. Activation SIRT1 that was shown to be involved in well-known signal pathways diabetic cardiomyopathy has protective effect against oxidative stress, inflammatory processes, apoptosis the basis diseases such obesity, diabetes mellitus, or cardiovascular diseases. The aim our study evaluate antidiabetic cardioprotective effects...
This study aimed at the relationship between antioxidant capacity, antimicrobial activity, and in vitro evaluation of wound healing effect extract obtained from Echinaceae purpureae folium (EPF). study's objective was to assess bioactive components (total phenol flavonoid content) activity EPF extracts using DPPH test method. The capacity quantities compounds with were evaluated by spectrophotometric methods. Antimicrobial has been investigated against various pathogenic microorganisms....
Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive impairment. Physical exercise has long been proven to be beneficial in the disorder. The present study was designed examine effect of voluntary on spatial memory, imaging, and pathological abnormalities. Particular focus given role heme oxygenase-1 (HO-1)-an important cellular cytoprotectant preserving mental acuity-using an aging rat model dementia. Male female Wistar rats were segregated into six groups-namely, (i)...
Fenugreek is a common herb possessing several bioactive components including diosgenin. Here, dietary fenugreek seed flour and diosgenin were evaluated on model of endothelium-dependent vasorelaxation by abdominal aortas isolated from rats receiving high-fat, high-sugar diet (HFHSD). 60 male Wistar randomized into six groups: (i) negative control getting conventional rat feed regimen; (ii) positive HFHSD; (iii) test group fed 2 g/kg bw/day (containing 10 mg/kg diosgenin) + (iv) three groups...
In developed, developing and low-income countries alike, type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases, severity which substantially a consequence multiple organ complications that occur due to long-term progression disease before diagnosis treatment. Despite enormous investment into characterization disease, its management remains problematic, with those afflicted enduring significant degradation in quality-of-life. Current research efforts etiology pathogenesis...
Right-sided heart failure—often caused by elevated pulmonary arterial pressure—is a chronic and progressive condition with particularly high mortality rates. Recent studies our current findings suggest that components of Wild garlic (Allium ursinum, AU) may play role in reducing blood pressure, inhibiting angiotensin-converting enzyme (ACE), as well improving right ventricle function rabbit models failure. We hypothesize AU mitigate cardiovascular damage hypertension (PAH) has value the...
Background and Aims: Diabetic cardiomyopathy (DCM) is an emerging problem worldwide due to increase in the incidence of type 2 diabetes. Animal studies have indicated that metformin pioglitazone can prevent DCM partly by normalizing insulin resistance, other, pleiotropic mechanisms. One clinical study has evidenced insulin-senzitizing effect drug candidate BGP-15, along with additional animal confirmed its beneficial effects models diabetes, muscular dystrophy heart failure, affecting...
Impaired mitochondrial function is associated with several metabolic diseases and health conditions, including insulin resistance type 2 diabetes (T2DM), as well ageing. The close relationship between the above-mentioned cardiovascular disease (CVD) (diabetic cardiomyopathy age-related diseases) has long been known. Mitochondria have a crucial role: they are primary source of energy produced in form ATP via fatty acid oxidation, tricarboxylic (TCA) cycle, electron transport chain (ETC),...
High blood glucose and the consequential ischemia-reperfusion (I/R) injury damage vessels of retina, deteriorating its function, which can be clearly visualized by electroretinography (ERG). The aim present study was to evaluate possible retinoprotective effects systemic BGP-15, an emerging drug candidate, in insulin resistant animal model, Goto-Kakizaki rat, compare these results with well-known anti-diabetics such as glibenclamide, metformin, pioglitazone, even led some novel conclusions...
Numerous studies have indicated a link between vaccines and the exacerbation of autoimmune diseases including rheumatoid arthritis (RA). However, there is no consensus in clinical practice regarding optimal timing immunization. Therefore, this study aimed to investigate impact 3Fluart influenza vaccine on complete Freund’s adjuvant (CFA)-induced chronic rat model identify new biomarkers with utility. CFA was injected into plantar surface one hind paw root tail day 0, injection repeated 1....
Meal-induced insulin sensitization (MIS), an endogenous adaptive mechanism is activated post-prandially. Reduced MIS leads to diabetes, but its activation improves sensitivity. preserved single olanzapine administration, therefore we aimed investigate the chronic effect of on fasted-state sensitivity and in female Sprague–Dawley rats. Daily food water intake, stool urine production body weight were determined. The was characterized by a rapid test. Fasting hepatic peripheral determined...
The COVID-19 pandemic has posed a huge challenge to the world in recent years. development of vaccines that are as effective possible and accessible society offers promising alternative for addressing problems caused by this situation soon restore pre-epidemic system. present study investigated preferences residents Hungary’s second-largest city (Debrecen) vaccine. To achieve aim, discrete choice experiment was conducted with 1011 participants, vaccine characteristics included design were...
Based on in silico results, recently we have assumed that FSCPX, an irreversible A₁ adenosine receptor antagonist, inhibits the action of NBTI is apparent E/c curves agonists. As a mechanism for this unexpected effect, hypothesized FSCPX might modify equilibrative and NBTI-sensitive nucleoside transporter (ENT1) way allows ENT1 to transport but impedes inhibit transport. This assumption implies our method developed estimate reserve agonists with short half-life such as adenosine, its...
In the dental office, diabetes mellitus is a chronic affection that many patients suffer. Apart from treatment of all diabetic patients, they use homeopathic medicines. We consider importance knowing these extracted hypoglycemic plants and their way acting by dentist.In this study we investigated some extracts obtained vegetal sources used hypoglycaemic action: Juglans regia L. -nut, Morus nigra -black mulberry, Olea europaea -olive. followed level antioxidant compounds capacity in alcoholic...
Cardiovascular morbidity and mortality carry great socioeconomic burden worldwide that mandates the development of new, efficacious therapeutic agents with limited adverse effects. O-(3-piperidino-2-hydroxy-1-propyl) nicotinic acid amidoxime (BGP-15) is a known, well-tolerable drug candidate exerts beneficial effects in several disease models. As BGP-15 has significant structural similarity propranolol, it arose might also have direct effect on heart. Thus, present work, we investigated...
In earlier studies, we generated concentration-response (E/c) curves with CPA (N6-cyclopentyladenosine; a selective A1 adenosine receptor agonist) or adenosine, in the presence absence of S-(2-hydroxy-5-nitrobenzyl)-6-thioinosine (NBTI, nucleoside transport inhibitor), and without pretreatment 8-cyclopentyl-N3-[3-(4-(fluorosulfonyl)-benzoyloxy)propyl]-N1-propylxanthine (FSCPX, chemical known as selective, irreversible antagonist), isolated, paced guinea pig left atria. Meanwhile, observed...
Background and Purpose The small molecule BGP‐15 has been reported to alleviate symptoms of heart failure improve muscle function in murine models. Here, we investigated the acute chronic effects a rabbit model atherosclerotic cardiomyopathy. Experimental Approach Rabbits were maintained on standard chow (control) or atherogenic diet (hypercholesterolemic) for 16 weeks. was administered intravenously (once) orally (for weeks), assess effects. Cardiac evaluated by echocardiography,...
Journal Article FUNCTIONAL AND MORPHOLOGICAL CHANGES IN THE ADRENAL-RENAL SYSTEM DURING HEPARIN POTASSIUM TREATMENT RATS Get access E Gláz, Gláz II. Department of Medicine and Institute Anatomy, University BudapestInstitute Pathology, Debrecen Search for other works by this author on: Oxford Academic Google Scholar R Kiss, Kiss V Morvai, Morvai N Péteri, Péteri Ch Sugár, Sugár F Hajós, Hajós G Dauda Acta Endocrinologica (Norway), Volume 61, Issue 1_Supplement, Aug 1969, Page S127,...
The receptorial responsiveness method (RRM) is a procedure that based on simple nonlinear regression while using model with two variables (X, Y) and (at least) one parameter to be determined (cx). of RRM describes the co-action agonists consume same response capacity (due use postreceptorial signaling in biological system). While RRM, uniquely, an acute increase concentration agonist (near receptors) can quantified (as cx), via evaluating E/c curves were constructed or another system. As...